Results 111 to 120 of about 721,729 (294)

Normalization of C1 Inhibitor in a Patient with Hereditary Angioedema [PDF]

Hereditary angioedema is a potentially life-threatening autosomal dominant condition, causing attacks of angioedema due to failure to regulate bradykinin. Nearly all cases of hereditary angioedema are caused by mutations in the gene encoding C1 inhibitor,
Sharif, Khalid, Kelly, Dominic, Mac Lochlainn, Dylan J., Dhalla, Fatima, Peters, Nicholas E.; id_orcid, Gupte, Girish L., Patel, Smita Y., Jain, Rashmi, Howarth , Lucy   +8 more
core   +1 more source

QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study

Advanced Science, EarlyView.
The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda, Ada Bernaus Vives, Michał Wojciechowski, Dinh Quoc Huy Pham, Mateusz Chwastyk, Mario Vallejo, Anna Novials, Douglas V. Laurents, Mariano Carrión‐Vázquez   +8 more
wiley   +1 more source

The physician and hereditary angioedema friend or foe: 62-year diagnostic delay and iatrogenic procedures

Allergy, Asthma & Clinical Immunology, 2018
Background Hereditary angioedema due to C1 inhibitor deficiency (C1-INH-HAE) is a rare autosomal dominant disease characterized by episodes of acute subcutaneous swelling, and/or recurrent severe abdominal pain.
Anna Valerieva, Marco Cicardi, James Baraniuk, Maria Staevska   +3 more
doaj   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Herediter anjioödemde kısa dönem danazol profilaksisi ile implant tedavisi: Vaka raporu

Selcuk Dental Journal, 2019
Herediter anjio ödem (HAÖ), C1 esteraz inhibitör proteininin konjenital eksikliğine bağlı olarak meydana gelen, nadir gözlenen, otozomal dominant bir hastalıktır. HAÖ atakları, spontan veya bir travmaya bağlı olarak, ekstremitelerde, yüzde, göğüste, hava
Zeynep Burçin Gönen, Fatma Doğruel, Canay Yılmaz Asan, Leylagül Kaynar, Mustafa Çetin   +4 more
doaj   +1 more source

C1-inhibitor deficiency and angioedema : molecular mechanisms and clinical progress

, 2009
C1 inhibitor (C1-INH, also known as SERPING1) can be deficient in plasma as a result of genetic or acquired conditions, and this causes an episodic, local increase in vascular permeability in the subcutaneous and submucosal layers, identified as ...
A. Zanichelli, M. Cicardi, Andrea Zanichelli, Massimo Cugno, Sonia Caccia, Marco Cicardi, Fabrizio Foieni, M. Cugno, F. Foieni, S. Caccia   +9 more
core   +1 more source

Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro‐Inflammatory Endothelial Cells

Advanced Science, EarlyView.
Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia, William Y. Wang, Kyle A. Jacobs, Kairav Maniar, Daphne Lin, Evan H. Jarman, Daniel L. Matera, Kristen Loesel, Christopher D. Davidson, Harrison L. Hiraki, Xiaotian Tan, Eve H. Shikanov, Robert N. Kent, Carole Parent, Xudong Fan, Ariella Shikanov, Matthew L. Kutys, Brendon M. Baker   +17 more
wiley   +1 more source

A method for creating a class of triangular C1 finite elements

, 2011
Finite elements providing a C1 continuous interpolation are useful in the numerical solution of problems where the underlying partial differential equation is of fourth order, such as beam and plate bending and deformation of strain-gradient-dependent ...
A. Zervos, Zervos, A, Papanicolopulos, S-A, Papanicolopulos, S.-A., S.-A. Papanicolopulos, Zervos, A.   +5 more
core   +1 more source

Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti‐Inflammatory Response Syndromes by Targeting PF4+ Macrophages in Acute Pancreatitis

Advanced Science, EarlyView.
ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu, Guanqun Li, Dongxu Lu, Haoran Ding, Tianqi Lu, Yuhang Sui, Can Zhang, Yu Xie, Rui Kong, Hua Chen, Xuewei Bai, Hongtao Tan, Dongbo Xue, Xianzhi Meng, Le Li, Bei Sun   +15 more
wiley   +1 more source

C1-inhibitor-serine proteinase complexes and the biosynthesis of C1-inhibitor by Hep G2 and U 937 cells

, 1993
The biosynthesis of the serpin alpha 1-proteinase inhibitor is regulated by a feedback mechanism whereby complexes between alpha 1-proteinase inhibitor and serine proteinases bind to liver cells and monocytes, a reaction that activates alpha 1-proteinase-
Schapira, M., Medcalf, R. L., Kourteva, Y., Patston, P. A.   +3 more
core