Results 161 to 170 of about 119,784 (210)
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2014
Autoantibodies to C1 inhibitor (C1-INH) bind to epitopes on the reactive center of the C1-INH molecule. As a consequence of this binding, C1-INH is converted into an inactive substrate that can be cleaved by proteases. C1-INH is a serine protease inhibitor that plays a role in the complement, contact, fibrinolytic, and coagulation cascades ...
Zanichelli, A +3 more
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Autoantibodies to C1 inhibitor (C1-INH) bind to epitopes on the reactive center of the C1-INH molecule. As a consequence of this binding, C1-INH is converted into an inactive substrate that can be cleaved by proteases. C1-INH is a serine protease inhibitor that plays a role in the complement, contact, fibrinolytic, and coagulation cascades ...
Zanichelli, A +3 more
openaire +3 more sources
1993
Publisher Summary This chapter discusses C1 inhibitor (C1 INH). C1 INH is a member of the serine proteinase inhibitor (serpin) superfamily. C1 INH is the only physiologically important plasma inhibitor of activated Clr and Cls, and it provides a major portion of the plasma inhibitory capacity toward kallikrein and factor XIIa, but probably is not ...
Alvin E. Davis +4 more
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Publisher Summary This chapter discusses C1 inhibitor (C1 INH). C1 INH is a member of the serine proteinase inhibitor (serpin) superfamily. C1 INH is the only physiologically important plasma inhibitor of activated Clr and Cls, and it provides a major portion of the plasma inhibitory capacity toward kallikrein and factor XIIa, but probably is not ...
Alvin E. Davis +4 more
openaire +1 more source
C1 Inhibitor: Quantification and Purification
2013C1 inhibitor is a multipotent serpin capable of inhibiting the classical and the lectin pathways of complement, the fibrinolytic system, and contact/kinin system of coagulation. Deficiency of C1 inhibitor manifest as hereditary angioedema (HAE), an autosomal dominant hereditary disease.
Varga, Lilian, Dobó, József
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Nihon rinsho. Japanese journal of clinical medicine, 2000
Ranol Zahedi, Alvin E. Davis
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Ranol Zahedi, Alvin E. Davis
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Biological effects of C1 inhibitor
Drug News & Perspectives, 2004C1 inhibitor is a serine proteinase inhibitor (serpin) that regulates activation of both the complement and contact systems. Regulation of complement system activation takes place through inactivation of the classical pathway proteases, C1r and C1s, the lectin pathway protease, MASP2, and perhaps via inhibition of alternative pathway activation by ...
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