Results 171 to 180 of about 3,095,271 (376)

C1 Inhibitor: Analysis of the Role of Amino Acid Residues Within the Reactive Center Loop in Target Protease Recognition [PDF]

, 2001
Rana Zahedi, Ryan C. MacFarlane, Jeffrey J. Wisnieski, Alvin E. Davis   +3 more
openalex   +1 more source

Modifying Glucose Metabolism Reverses Memory Defects of Alzheimer's Disease Model at Late Stages

Advanced Science, EarlyView.
Using spatial transcriptomics, we show that ferul enanthate (SL‐ZF‐01) reverses episodic‐like memory deficits in aged, but not young, Alzheimer’s disease (AD) mice. SL restores glucose metabolism and Glucose Transporter 1/3 expression via an ‘Aging‐AD‐Rescue’ pattern, rescuing deficits seen in aged AD mice.
Fang Liu, Yiyu‐Li Tang, Zong‐Bo Zhang, Ya‐Hong Tan, Si‐Hui Lin, Ni‐Ya Wang, Jin‐Nan Li, Zhi‐Jie Pan, Jian‐Feng Li, Jing‐Fei Huang, Yu‐Qiang Ding, Chun‐Ming Guo, Lin Xu, Cheng Peng, Qi‐Xin Zhou   +14 more
wiley   +1 more source

Vitamin D Regulates Olfactory Function via Dual Transcriptional and mTOR‐Dependent Translational Control of Synaptic Proteins

Advanced Science, EarlyView.
Vitamin D (VitD) modulates olfactory function by remodeling dendrodendritic synapses in tufted cells through vitamin D receptor‐dependent transcriptional and translational mechanisms. VitD regulates synaptic protein translation partially via mTOR signaling.
Pengcheng Ren, Renhe Cao, Xiaoshan Ye, Wenbin Pang, Qingshang Bi, Meihui Huang, Qionglin Zhou, Dan Ye, Wei Xiang, Le Xiao   +9 more
wiley   +1 more source

Infektív, genetikai és complement aktivációs tényezők szerepének vizsgálata az autoimmun betegségek patogenezisében = Investigation of the role of infective, genetic and complement activation factor in the pathogenesis of autoimmune disorders [PDF]

, 2008
Az MBL2 gén polimorfizmusa az SLE kialakulásának rizikó faktora. 315 SLE-s betegben és 182 kontrollban az MBL2 polimorfizmust vizsgáltuk. Kimutattuk, hogy az MBL2 polimorfizmusában a homozigóta SLE-s betegekben szignifikánsan fiatalabb életkorban (p=0 ...
Backhauszné dr. Takács, Edit Katalin, Farkas, Henriette, Fekete, Béla, Jakab, László, Kalabay, László, Pozsonyi, Teréz, Temesszentandrási, György, Varga, Lilian Ágnes   +7 more
core  

Acquired C1-inhibitor deficiency presenting with nephrotic syndrome

, 2019
Jamie Willows, Katrina Wood, Helen Bourne, John A. Sayer   +3 more
openalex   +2 more sources

Strawberry Notch 1 Acts as a Transcriptional Regulator Driving Oncogenic Programs in Liver Carcinogenesis

Advanced Science, EarlyView.
This study reports that SBNO1 protein is upregulated in several cancer entities. SBNO1 protein interacts with the basal transcription factor TFIID via TAF4, enabling its recruitment to transcription start sites and the modulation of target gene expression.
Sarah Fritzsche, Raisatun Nisa Sugiyanto, Kira Gür, Alina Krumme, Maxime Le Marois, Angelika Fraas, Aslihan Inal, Mario Huerta, Vanessa Henriques, Eva Eiteneuer, Thomas Albrecht, Alphonse Charbel, Michael T. Dill, Carsten Sticht, Carolina De La Torre, Stefan Pusch, Arianeb Mehrabi, Kai Breuhahn, Junfang Ji, Peter Schirmacher, Benjamin Goeppert, Stephanie Roessler   +21 more
wiley   +1 more source

Prevention of Hereditary Angioedema Attacks with a Subcutaneous C1 Inhibitor

New England Journal of Medicine, 2017
H. Longhurst, M. Cicardi, T. Craig, K. Bork, C. Grattan, J. Baker, Huamin H. Li, A. Reshef, J. Bonner, J. Bernstein, John Anderson, W. Lumry, H. Farkas, C. Katelaris, G. Sussman, J. Jacobs, M. Riedl, M. Manning, J. Hébert, P. Keith, S. Kivity, S. Neri, D. Levy, M. Baeza, R. Nathan, L. Schwartz, T. Caballero, William H. Yang, I. Crişan, M. D. Hernández, I. Hussain, M. Tarzi, B. Ritchie, P. Kralickova, M. Guilarte, S. Rehman, A. Banerji, R. Gower, D. Bensen-Kennedy, J. Edelman, H. Feuersenger, J. Lawo, T. Machnig, Dipti K. Pawaskar, I. Pragst, B. Zuraw   +45 more
semanticscholar   +1 more source

Procyanidin C1 inhibits bleomycin‐induced pulmonary fibrosis in mice by selective clearance of senescent myofibroblasts [PDF]

Min Shao, Yujia Qiu, Mengxia Shen, Wei Liu, Dandan Feng, Ziqiang Luo, Yan Zhou   +6 more
openalex   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

[Hereditary angioedema due to C1-inhibitor deficiency, a national disease management programme]. [PDF]

Wien Klin Wochenschr, 2023
Aberer W, Altrichter S, Cerpes U, Hawranek T, Schöffl C, Kinaciyan T.   +5 more
europepmc   +1 more source