Results 81 to 90 of about 3,095,271 (376)

Treatment of hereditary angioedema with plasma-derived C1 inhibitor

Therapeutics and Clinical Risk Management, 2008
Michael J Prematta, Tracy Prematta, Timothy J CraigSection of Allergy and Immunology, Penn State University, Milton S. Hershey Medical Center, PA, USABackground: Plasma-derived C1 inhibitor (C1-INH) concentrate is a treatment option for acute hereditary ...
Michael J Prematta, Tracy Prematta, Timothy J Craig   +2 more
doaj  

Delving into Vertebrate Serpins for Understanding their Evolution [PDF]

, 2009
The superfamily of serine proteinase inhibitors (serpins) is involved in an array of fundamental biological processes such as blood coagulation, cell differentiation, cell migration, complement activation, embryo implantation, fibrinolysis, angiogenesis,
Abhishek Kumar
core   +2 more sources

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

The international WAO/EAACI guideline for the management of hereditary angioedema – the 2017 revision and update [PDF]

, 2018
Hereditary Angioedema (HAE) is a rare and disabling disease. Early diagnosis and appropriate therapy are essential. This update and revision of the global guideline for HAE provides up-to-date consensus recommendations for the management of HAE.
Aabom, Abdel-Karim, Agostoni, Alexander Nast, Anete S. Grumach, Antonio, Aygoren-Pursun, Aygoren-Pursun, Banerji, Banerji, Banta, Bas, Bas, Berkel, Bernstein, Bernstein, Bernstein, Bernstein, Betschel, Binkley, Black, Blackmore, Blohme, Boccon-Gibod, Bonnekoh, Bork, Bork, Bork, Bork, Bork, Bork, Bork, Bork, Bork, Bork, Bork, Bork, Bork, Bouillet, Bouillet, Bouillet, Bouillet, Bowen, Bowen, Bowen, Bowen, Boyle, Brackertz, Brozek, Brozek, Bruce Ritchie, Bruce Zuraw, Brunskill, Bygum, Bygum, Caballero, Caballero, Caballero, Caballero, Caballero, Caballero, Caldwell, Caliskaner, Christiansen, Cicardi, Cicardi, Cicardi, Cicardi, Cicardi, Cicardi, Constance Katelaris, Craig, Craig, Craig, Craig, Craig, Craig, Craig, Cronin, Crowther, Czaller, de Maat, de Rojas Hernandez Fernandez, De Serres, Dewald, Dinkelacker, Donaldson, Donaldson, Donaldson, Dumitru Moldovan, Emel Aygören-Pürsün, Erikson, Farkas, Farkas, Farkas, Farkas, Farkas, Farkas, Farkas, Farkas, Farkas, Farkas, Farkas, Farkas, Farrell, Fernando, Fields, Forrest, Fox, Frank, Frank, Fust, Galan, Germenis, Gilad, Gobert, Gompels, Gonzalez-Quevedo, Gorman, Greve, Grumach, Guyatt, Halbmayer, Hedner, Henriette Farkas, Henrik Balle Boysen, Hilary Longhurst, Hochberg, Hofstra, Ignacio Ansotegui, Inmaculada Martinez-Saguer, Jacques, Jurado-Palomo, Kalaria, Kaplan, Kaplan, Kaplan, Karim, Kohalmi, Konrad Bork, Kreuz, Kunschak, Lang, Lanny Rosenwasser, Levy, Li, Longhurst, Longhurst, Longhurst, Lopez-Lera, Lumry, Lumry, Lumry, Magerl, Magerl, Magerl, Marc Riedl, Marcus Maurer, Mario Sánchez-Borges, Markus Magerl, Martinez-Saguer, Martinez-Saguer, Martinez-Saguer, Martinez-Saguer, Martinez-Saguer, Maurer, Maurer, Maurer, Michihiro Hide, Moldovan, Moldovan, Muhlberg, Nanda, Nasr, Nathani, Nielsen, Nussberger, Ogston, Pappalardo, Pappalardo, Paul Potter, Pedrosa, Peveling-Oberhag, Rahal, Rasmussen, Reshef, Richard Lockey, Riedl, Riedl, Riedl, Riedl, Rocha, Rosen, Rosen, Ruby Pawankar, Saule, Schreiber, Schulz, Sheffer, Sheffer, Spath, Speletas, Staubach, Stephen Betschel, Tarzi, Terpstra, Thoufeeq, Timothy Craig, Toh, Tom Bowen, Tourangeau, Tuong, van Doorn, van Veen, Visy, Waytes, Weiler, Wentz, Whalley, Whalley, William R. Lumry, Wilson, Wu, Yuxiang Zhi, Zanichelli, Zanichelli, Zanichelli, Zilberberg, Zotter, Zotter, Zotter, Zuberbier, Zuraw, Zuraw, Zuraw, Zuraw, Zuraw, Zuraw, Ärzteschaft   +238 more
core   +2 more sources

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Regulation of C1 Inhibitor Synthesis

Immunobiology, 1998
The primary biologic roles of C1 inhibitor (C1-INH) are the regulation of activation of the classical complement pathway and of the contact system of kinin formation. Heterozygosity for deficiency or dysfunction of C1-INH results in hereditary angioedema (HAE).
A E, Prada, K, Zahedi, A E, Davis
openaire   +2 more sources

Classification, diagnosis, and approach to treatment for angioedema: Consensus report from the Hereditary Angioedema International Working Group [PDF]

, 2014
Angioedema is defined as localized and self-limiting edema of the subcutaneous and submucosal tissue, due to a temporary increase in vascular permeability caused by the release of vasoactive mediator(s). When angioedema recurs without significant wheals,
Adam, Agostoni, Agostoni, Agostoni, Alsenz, Alsenz, Bafunno, Bas, Beltrami, Benson, Bentsianov, Binkley, Blais, Blanch, Blohme, Bork, Bork, Bork, Bork, Bork, Bork, Bork, Bork, Bork, Bork, Bork, Bouillet-Claveyrolas, Bowen, Bowen, Branellec, Brasher, Brecy, Bright, Brown, Brown, Burkhart, Bygum, Bygum, Byrd, Byrd, Caballero, Caldwell, Campo, Castelli, Cicardi, Cicardi, Cicardi, Cicardi, Cicardi, Cicardi, Cicardi, Cicardi, Cichon, Cocchio, Colas, Corso, Corte, Craig, Craig, Cugno, Cugno, Cugno, Cugno, Cupido, D'Incan, Dean, Dewald, Dobbels, Donaldson, Donaldson, Donaldson, Du-Thanh, Duan, Farkas, Farkas, Fields, Frank, Gelee, Gelfand, Gompels, Grant, Hassan, Hauptmann, Hauptmann, He, Jackson, Jackson, Jackson, Kalmar, Kalmar, Kaplan, Kiss, Kostis, Kostis, Lam, Levi, Lin, Longhurst, Longhurst, Lopez-Lera, Lopez-Lera, Lumry, Makani, Mandle, Marcos, Martin, Martinez-Saguer, Messerli, Miller, Molinaro, Montinaro, Nielsen, Nussberger, Nussberger, Osler, Pappalardo, Pappalardo, Patel, Pellacani, Quinke, Roche, Roche, Rosen, Rye Rasmussen, Sanchez-Borges, Sanchez-Cano, Sands, Schreiber, Slater, Steinbach, Stray-Pedersen, Tarzi, Tedeschi, Thelwel, Toh, Tosi, Vitrat-Hincky, Wagenaar-Bos, Waytes, Weller, Wilson, Zanichelli, Zanichelli, Ziakas, Zingale, Zingale, Zuberbier, Zuraw, Zuraw, Zuraw, Zuraw, Zuraw   +151 more
core   +1 more source

Atomic Size Misfit for Electrocatalytic Small Molecule Activation

Advanced Functional Materials, EarlyView.
This review explores the application and mechanisms of atomic size misfit in catalysis for small molecule activation, focusing on how structural defects and electronic properties can effectively lower the energy barriers of chemical bonds in molecules like H2O, CO2, and N2.
Ping Hong, Changfan Xu, Huaping Zhao, Yong Lei   +3 more
wiley   +1 more source

C1-inhibitor protects against brain ischemia–reperfusion injury via inhibition of cell recruitment and inflammation

Neurobiology of Disease, 2005
Previous studies demonstrated that C1-inhibitor (C1-INH), a complement and contact-kinin systems inhibitor, is neuroprotective in cerebral ischemia.
Claudio Storini, Emanuela Rossi, Veronica Marrella, Maria Distaso, Robert Veerhuis, Carlo Vergani, Luigi Bergamaschini, Maria-Grazia De Simoni   +7 more
doaj   +1 more source

C1-Inhibitor and Transplantation

Immunobiology, 2002
Excessive activation of the protein cascade systems has been associated with post-transplantation inflammatory disorders. There is increasing evidence that complement not only significantly contributes to ischemia/reperfusion injury upon cold storage of the organ but also, although to a different degree, to allograft rejection. Complement activation is
openaire   +2 more sources