Results 101 to 110 of about 878,820 (240)
Advanced Science, EarlyView.PDGFA/PDGFRα signaling recruits CAFs to OSCC nests, and CAF‐OSCC contact drives tumor budding invasion. Mechanistically, heterotypic adhesion via E‐cadherin/integrin α2β1 activates YAP signaling in OSCC cells, inducing EMT. Concurrently, CAFs transfer mitochondria through TNTs, supplying ATP to fuel invasion.
Yufang Liu +17 more
wiley +1 more source
Antiproteasic activity of C1 inhibitor. Therapeutic perspectives
, 1994 Kallikrein is a protease involved in the inflammatory process causing acute pancreatitis. Attempts to prevent this process with antiprotease agents have been successful in experimental animal models but disappointing in humans.
P. Testoni +6 more
core +2 more sources
Pd‐Catalyzed Asymmetric Dearomative Heck/Tsuji‐Trost Difunctionalization of Naphthalenes
Advanced Science, EarlyView.We have developed a palladium‐catalyzed asymmetric dearomative Heck/Tsuji‐Trost 1,4‐difunctionalization reaction of naphthalenes, affording 4‐aminospirocyclohexene oxindole products bearing two remote chiral centers. Through the effect of the newly designed chiral sulfinamide phosphine ligand with large steric hindrance, side reactions are inhibited ...
Long‐Ling Ma +3 more
wiley +1 more source
, 2004 Activation of plasma prekallikein and generation of bradykinin are responsible for the angioedema attacks observed with C1-inhibitor deficiency. Heterozygous individuals with
Schapira, M. +4 more
core +1 more source
Advanced Science, EarlyView.A catalysis system with adjustable interfacial H2O configuration was conducted by introducing ionomer into Cu. The increasing proportion of K+‐H2O can enhance the dissociation of H2O and improve the generation ability of *H, and the increasing proportion of 4‐HB‐H2O can accelerate the transfer speed of *H to *CO intermediates with the aid of strong ...
Dawei Zhou +5 more
wiley +1 more source
Advanced Science, EarlyView.Schematic diagram showing compressive stress triggers glycolytic reprogramming and lactate accumulation in macrophages. Lactate mediates TRAF6 lactylation at K171/K180 dual sites, which enhances its K63‐linked ubiquitination to activate the NF‑κB pathway and promote M1 polarization. This cascade drives orthodontic tooth movement (OTM) and alveolar bone
Xinyi He +9 more
wiley +1 more source
Deconstruction of Human Age‐Related Cataract Capsules Defines Aging
Advanced Science, EarlyView.We generate a comprehensive atlas of age‐related cataracts (ARC) at a single‐cell resolution, encompassing three disease states—mild cataract group (Mild), severe cortical cataract group (Severe_C), and severe nuclear cataract group (Severe_N). We find that ARC involves seven distinct lens capsule cell types, with notable differences in cellular ...
Qiaomei Tang +9 more
wiley +1 more source
Advanced Science, EarlyView.In bladder cancer, LRG1 binds to ANXA2 to trigger mitochondrial ROS‐dependent NETosis. This pathogenic cascade actively uncouples endothelial‐mural cell interactions, driving profound vascular destabilization. Consequently, targeting the LRG1‐ANXA2 axis attenuates the neutrophil burden and induces structural vascular normalization, offering a powerful ...
Dongshan Chen +8 more
wiley +1 more source
Monocyte C1-inhibitor synthesis in patients with C1-inhibitor deficiency
, 1989 Monocytes of seven out of eight patients with type 1 C1-inhibitor (C1-inh) deficiency (HAE) produced 40% as much C1-inh as monocytes from normal donors (controls). In contrast, monocytes from three patients with type 2 and three patients with acquired C1-
McPhaden, A.R. +13 more
core +1 more source
A case of remittent C1-inhibitor deficiency
, 2015 C1-inhibitor is a serine protease inhibitor (serpin) controlling complement and kinin/contactsystem activation. Mutations in C1-inhibitor gene almost consistently result in reduced C1-inhibitor functional level in plasma causing hereditary angioedema, a ...
Drouet, Christian +13 more
core +2 more sources