Results 91 to 100 of about 214,320 (304)

Coacervates Made of Elastin‐Like Polypeptides Fused with Melanocyte‐Stimulating Hormone and Monocyte Chemoattractant Protein Enhance Skin Wound Healing in Spinal Cord‐Injured Mice

Advanced Healthcare Materials, EarlyView.
Pressure skin wounds are frequent complications after spinal cord injury (SCI), with impaired healing due to vascular and immune deficits. Elastin‐like polypeptides (ELP) fused to α‐MSH (MSH‐ELP) or MCP‐1 (MCP‐ELP) are developed and tested on these wounds. The resulting nanoparticles are non‐toxic and bioactive, and they enhance macrophage recruitment,
Suneel Kumar, Dhruv Patel, Greeshma Manjunath, Shashank Madhavan, Ashley Mathew, Dnyaneshwari Rananavare, Jahnavi Shah, Francois Berthiaume   +7 more
wiley   +1 more source

Clinical profile of patients with C1-inhibitor deficiency from Eastern India

Indian Journal of Allergy Asthma and Immunology, 2016
C1-inhibtor deficiency or hereditary angioedema is a rare, autosomal dominant disorder that is characterized by severe episodic attacks of angioedema that can affect any part of the body.
Sujoy Khan
doaj   +1 more source

Jun Activation Domain-binding Protein 1 Antisense (P27Kip1) Induces Apoptosis of an Oral Tongue Cancer Cell [PDF]

, 2011
Jun activation domain-binding protein (Jab1) berperan sebagai koaktivator dari aktivator protein 1 yang terlibat dalam degradasi cyclin-dependent kinase inhibitor p27Kip1.
Supriatno, S. (Supriatno)
core  

Simvastatin Restores Uteroplacental Hemodynamics and Trophoblast Function in Obstetric Antiphospholipid Syndrome in a Placenta‐on‐a‐Chip Model

Advanced Healthcare Materials, EarlyView.
Simvastatin mitigates placental hypoperfusion in OAPS by ameliorating abnormal uteromaternal hemodynamics and enhancing trophoblast invasion via optimized endothelial cell interactions under pathological shear stress, as evidenced by results from a placenta‐on‐a‐chip platform.
Hongli Liu, Yuan Wang, Yanjun Cai, Ruixin Guo, Shunhua Liu, Tingting Chen, Tingting Sun, Ruiheng Huo, Tengwei Liu, Qingfeng Lv, Xietong Wang   +10 more
wiley   +1 more source

Insights into the Purification of C1-esterase Inhibitor from Human Plasma

Plasmatology
Hereditary angioedema (HAE) is a rare but often life-threatening genetic disorder caused by either lack of or dysfunctional C1-esterase inhibitor (C1-I3NH). C1-INH is a high-cost therapy for HAE.
Sachin Verma, Sheetal Dolia, Savan Makadia, Narendra Kumar   +3 more
doaj   +1 more source

Global research trends in hereditary angioedema, 1972–2023: Bibliometric analysis of productivity, collaboration, and thematic evolution

World Allergy Organization Journal
Background: Hereditary angioedema (HAE) is a rare, potentially life-threatening condition. In recent years, the emergence of novel therapies has likely contributed to substantial growth in HAE research; however, a comprehensive review of the HAE research
Hugo W.F. Mak, MBBS, MRes[Med], Hilary J. Longhurst, MBBS, PhD, Markus Magerl, MD, Jonny Peter, MBChB, PhD, Marc Riedl, MD, MS, Philip H. Li, MBBS, MD   +5 more
doaj   +1 more source

Nine year follow-up of a rare case of angioedema due to acquired C1-inhibitor deficiency with late onset and good response to attenuated androgen

Allergy, Asthma & Clinical Immunology, 2018
Background Angioedema due to acquired deficiency of C1-inhibitor (C1-INH-AAE) is a rare disease sharing some clinical and laboratory similarities with hereditary angioedema, but with late onset and no positive family history. The underlining cause may be
Polliana Mihaela Leru, Vlad Florin Anton, Horia Bumbea   +2 more
doaj   +1 more source

Regulation of C1 Inhibitor Synthesis

Immunobiology, 1998
The primary biologic roles of C1 inhibitor (C1-INH) are the regulation of activation of the classical complement pathway and of the contact system of kinin formation. Heterozygosity for deficiency or dysfunction of C1-INH results in hereditary angioedema (HAE).
A E, Prada, K, Zahedi, A E, Davis
openaire   +2 more sources

A Modular Bioinstructive Platform Reveals Mechanistic Insights into Additive‐Free, Topography‐Driven Osteogenesis

Advanced Healthcare Materials, EarlyView.
Engineered microparticle topographies direct human mesenchymal stem cell osteogenesis without biochemical additives. This osteogenic commitment is driven by canonical Hedgehog signaling and followed by temporal IGF‐II engagement. Two‐photon polymerization demonstrates spatial control, enabling the engineering of topographical gradients that pattern ...
Fatmah I. Ghuloum, Leo A. H. Zeef, Lee A. Stevens, Marco A. N. Domingos, Susan J. Kimber, Mahetab H. Amer   +5 more
wiley   +1 more source

Vasculopathy: a possible factor affecting hereditary angioedema

Bleeding, Thrombosis and Vascular Biology
Hereditary angioedema (HAE) is a rare genetic disorder that causes swelling of tissues in the hands, feet, limbs, face, intestinal tract, or airway. The SERPING1 gene, encoding the C1-INH, determines the wide range of clinical symptoms associated with ...
Anna Laura Colia, Alessandra Ranaldi, Rosa Santacroce, Giovanna D'Andrea, Angela Bruna Maffione, Maurizio Margaglione, Maria D'Apolito   +6 more
doaj   +1 more source