Results 191 to 200 of about 119,425 (295)

Synergistic HMGN1 and VP64 Fusions Potentiate High‐Precision and PAM‐Flexible Base Editing

Advanced Science, EarlyView.
A novel CDA1Δ‐SpRY architecture fused with HMGN1 and VP64 yields a nearly PAM‐less base editing platform. By focusing cytosine conversion predominantly at position −18, this synergistic complex ensures highly precise targeting. Demonstrating enhanced efficiency across diverse models, including yeast and rice, the platform offers a robust solution for ...
Xi Luo, Yuyao Qu, Zhengyan Ye, Zheng Li, Yuanyan Zhang, Longjiong Luo, Shaokang Li, Wei Zhao, Ming Wang, Ralph Bock, Jianmin Wan, Junjie Tan   +11 more
wiley   +1 more source

C1 inhibitor deficient hereditary angioedema is related to endothelial dysfunction in young adult and middle-aged patients. [PDF]

Clin Transl Allergy
Atay Sensoy GG, Baykız D, Toprak İD, Eyice Karabacak D, Bektas E, Unal D, Gelincik A, Demir S.   +7 more
europepmc   +1 more source

NAD+ Metabolism Licenses Zygotic Genome Activation via PARP7‐Mediated ADP‐Ribosylation of UHRF1 in Mouse Early Embryos

Advanced Science, EarlyView.
This study uncovers a metabolic‐epigenetic axis licensing zygotic genome activation (ZGA) in mouse embryos. A developmental decline in NAD+ levels activates PARP7, which mono‐ADP‐ribosylates and stabilizes UHRF1. This modification promotes the establishment of permissive histone acetylation marks, thereby facilitating timely ZGA.
Guangyi Cao, Ziqi Zhang, Anqi Chen, Yanbo Liu, Yuling Lin, Lina Yu, Ruixin Shi, Aolei Guo, Yan Mao, Ganggui Lou, Chaojun Li, Luhong Wen, Guijun Yan, Haixiang Sun   +13 more
wiley   +1 more source

Recurrent Intestinal Angioedema with Normal C1-Inhibitor: A Case Report. [PDF]

Medicina (Kaunas)
Jevtic D, Taylor A, Dumic I, Sviggum E, Nordstrom CW, Antic M.   +5 more
europepmc   +1 more source

Pericentrosomal Redistribution of the Endoplasmic Reticulum Ensures Organelle Symmetric Inheritance and Mitotic Progression

Advanced Science, EarlyView.
Upon mitotic entry, RTN4 relocalizes to the pericentrosomal region, forming a more tubular ER network around centrosomes. CDK1‐mediated phosphorylation of RTN4 increases its interaction with Rab11 GTPase, facilitating dynein‐dependent transport of RTN4 to the pericentrosomal region.
Xiangyu Xu, Yalin Liu, Rongyi Wang, Wenwen Xu, Hao Shi, Ning Huang, Junlin Teng, Jin Meng, Pengli Zheng, Jianguo Chen   +9 more
wiley   +1 more source

Global frequency, diagnosis, and treatment of hereditary angioedema with normal C1 inhibitor. [PDF]

J Allergy Clin Immunol Glob
Magerl M, Riedl MA, Arruda LK, Bauer A, Berardi A, Bernstein JA, Bouillet L, Buckland M, Buttgereit T, Cohn DM, Craig T, Criado RF, Du-Thanh A, Fain O, Gonçalo M, Greve J, Grumach AS, Guilarte M, Katelaris C, Kinaciyan T, Latysheva EA, Lleonart R, Llosa OC, Mansour E, Grivcheva-Panovska V, Parisi C, Rosario Filho NA, Santos AS, Staubach P, Valerieva A, Rodrigues Valle SO, Danese S, Ulloa J, Audhya PK, Maurer M.   +34 more
europepmc   +1 more source

Proteinase-proteinase inhibitor imbalance in inflammation and multiple trauma with special amphasis on release of granulocytic lysosomal elastase [PDF]

, 1984
Elödi, P., Jochum, Marianne, Dittmer, H., Fritz, Hans, Duswald, Karl-Heimo   +4 more
core   +1 more source

CHCHD10 Mitigates Alzheimer's Disease‐Related Phenotypes in Association With Epigenetic Remodeling in Directly Reprogrammed Neurons

Advanced Science, EarlyView.
CHCHD10 loss in Alzheimer's disease is associated with mitochondrial dysfunction, epigenomic disruption, and tau pathology. Restoration of CHCHD10 shifts DNA methylation toward a non‐disease state and reduces tau and amyloid pathology, with KATNAL2 acting as a downstream effector.
Teresa M. Thomas, Ching‐Yao Yang, Kexin Zhang, Liam Wetzel, Dina Bugybayeva, Julia Ferguson, Md Mahmudul Hasan, William Samsa, Nandita Patil, Anshul Dash, Tarini Gowda, Xiongwei Zhu, Feixiong Cheng, Tian Liu   +13 more
wiley   +1 more source

One-year real-life outcomes of lanadelumab therapy in Romanian patients with hereditary angioedema due to C1-inhibitor deficiency. [PDF]

Front Allergy
Bara NA, Nădășan V, Deleanu D.
europepmc   +1 more source

Retinomorphic Visual Processing Enabled by Contact‐Engineered IGZO Optoelectronic Synaptic Memtransistors

Advanced Science, EarlyView.
Here, we present an optoelectronic synaptic memtransistor (OSMT) integrating photoresponsive IGZO with contact‐engineered HfO2, enabling electrically and optically tunable synaptic weights. The device demonstrates broad range of tunable conductance states and array‐level image processing, highlighting its potential for intelligent machine vision ...
Donghyun Kang, San Nam, Dayul Nam, In‐Soo Kim, Myung‐Gil Kim, Sung Kyu Park, Yong‐Hoon Kim   +6 more
wiley   +1 more source