Results 231 to 240 of about 119,425 (295)

Hereditary angioedema with normal C1 inhibitor associated with carboxypeptidase N deficiency. [PDF]

J Allergy Clin Immunol Glob
Vincent D, Parsopoulou F, Martin L, Gaboriaud C, Demongeot J, Loules G, Fischer S, Cichon S, Germenis AE, Ghannam A, Drouet C.   +10 more
europepmc   +1 more source

A Crystalline and Thermally Stable Selenocysteine Selenenic Acid

Angewandte Chemie, EarlyView.
The long‐sought catalytic intermediate of selenoproteins, selenocysteine selenenic acid (Sec–SeOH), is isolated for the first time at ambient temperature. A bioinspired selenopeptide sequence encapsulated within a protective molecular cradle and an oxidant‐free route from selenenyl iodide (Sec–SeI) enable the isolation of Sec–SeOH. Contrary to the long‐
Ryosuke Masuda, Satoru Kuwano, Kei Goto
wiley   +2 more sources

Lanadelumab in a kidney transplant patient with hereditary angioedema due to C1-inhibitor deficiency and high cardiovascular risk - a case report. [PDF]

Front Immunol
Gidaro A, La Cava L, Donadoni M, Popescu Janu V, Cogliati C, Brucato AL, Zanichelli A, Cancian M, Bizzi E.   +8 more
europepmc   +1 more source

Transition Metal‐Free Heteroarene Insertion Into C─C Bonds of Benzocyclobutenones

Angewandte Chemie, EarlyView.
A transition metal‐free insertion of five‐membered heteroarenes into the C─C bonds of benzocyclobutenones has been achieved under mild and operationally simple conditions. This method provides an efficient and modular approach to access fused partially saturated hetero‐polycyclic scaffolds that exist in many bioactive molecules.
Cole J. Wagner, Guangbin Dong
wiley   +2 more sources

Screening for type II hereditary angioedema-the "poor man's c1-inhibitor function". [PDF]

J Allergy Clin Immunol Glob
Jindal AK, Chiang V, Barman P, Sil A, Chawla S, Au EYL, Rawat A, Li PH.   +7 more
europepmc   +1 more source

Real-world outcomes of patients with hereditary angioedema with normal C1-inhibitor function and patients with idiopathic angioedema of unknown etiology in Canada. [PDF]

Allergy Asthma Clin Immunol
Adatia A, Boursiquot JN, Goodyear D, Kalicinsky C, Kanani A, Waserman S, Nguyen MML, Wadhwa A, Weiss J, El-Zoeiby A, Betschel S.   +10 more
europepmc   +1 more source

A real-world study of hereditary angioedema patients due to C1 inhibitor deficiency treated with danazol in the Brazilian Public Health System. [PDF]

Front Med (Lausanne)
Ritter AMV, Silva S, de Paula R, Senra J, Carvalho F, Ribeiro T, Valle SOR.   +6 more
europepmc   +1 more source

Unlocking a Nitrosuccinate Lyase for Decarboxylative Enzymatic Hydronitration

Angewandte Chemie, EarlyView.
The nitrosuccinate lyase CreD catalyzes C–NO2 bond formation using nitrite in water and shows synthetic practicality with high turnover numbers up to 102,000. A combination of protein engineering and computational methods helped to reveal the mechanistic principles that underpin this unique enzymatic activity.
Matteo Aleotti, Hannah Dreisbach, Rémi Corlay, Clara Weber, Tamara Reiter, Wael Elaily, Bastian Daniel, Klaus Zangger, Pedro A. Sánchez‐Murcia, Mélanie Hall   +9 more
wiley   +1 more source

Rare connective tissue diseases in patients with C1-inhibitor deficiency hereditary angioedema: first evidence on prevalence and distribution from a large Italian cohort study. [PDF]

Front Immunol
Triggianese P, Senter R, Perego F, Gidaro A, Petraroli A, Arcoleo F, Brussino L, Giardino F, Rossi O, Bignardi D, Quattrocchi P, Brancaccio R, Cesoni Marcelli A, Accardo PA, Lo Sardo L, Cataudella E, Guarino MD, Firinu D, Bergamini A, Spadaro G, Zanichelli A, Cancian M.   +21 more
europepmc   +1 more source

Berotralstat in hereditary angioedema due to C1 inhibitor deficiency: first real-world evidence from a Canadian center. [PDF]

Front Immunol
Srinivasan C, Ritchie B, Adatia A.
europepmc   +1 more source