Results 131 to 140 of about 26,472 (244)

LRG1 Drives Pathological Angiogenesis by Disrupting Neutrophil Mitochondrial Homeostasis in Bladder Cancer

Advanced Science, EarlyView.
In bladder cancer, LRG1 binds to ANXA2 to trigger mitochondrial ROS‐dependent NETosis. This pathogenic cascade actively uncouples endothelial‐mural cell interactions, driving profound vascular destabilization. Consequently, targeting the LRG1‐ANXA2 axis attenuates the neutrophil burden and induces structural vascular normalization, offering a powerful ...
Dongshan Chen, Cong Zhang, Song Xue, Yuan Zeng, Haochen Cui, Chenfei Wang, Jiayi Feng, Lei Yan, Yuanwei Zang   +8 more
wiley   +1 more source

Population-scale analysis reveals inherited C1-inhibitor deficiency is a polyphenotypic thrombotic disorder. [PDF]

Blood Adv
Rodriguez Espada A, Haj AK, Jurgens SJ, Eswaran H, Sundler Björkman L, Ryu J, Chaudhry S, Koyama S, Wang X, Choi SH, Sanna-Cherchi S, Banerji A, Rämö JT, Ellinor PT, Grover SP, Bendapudi PK.   +15 more
europepmc   +1 more source

Hereditary angioedema due to C1 inhibitor deficiency: real-world experience from the Icatibant Outcome Survey in Spain. [PDF]

Allergy Asthma Clin Immunol, 2021
Guilarte M, Sala-Cunill A, Baeza ML, Cabañas R, Hernández MD, Ibañez E, de Larramendi CH, Lleonart R, Lobera T, Marqués L, de San Pedro BS, Botha J, Andresen I, Caballero T, IOS Study Group.   +14 more
europepmc   +1 more source

ZBTB11 Promotes Breast Cancer Progression by Activating FBXO28‐Mediated MST1 Degradation and Suppressing Hippo Signaling

Advanced Science, EarlyView.
ZBTB11 is identified as an oncogenic transcription factor that activates FBXO28 in breast cancer. FBXO28 promotes K48‐linked ubiquitination and degradation of MST1, suppressing Hippo signaling and enhancing epithelial–mesenchymal transition and metastasis. This transcription‐to‐ubiquitination cascade defines a prognostic biomarker axis and highlights a
An Xu, Xiang‐Nan Xu, Xiao Huang, Zhou Luo, Chun‐Lian Li, Yang Du, Cheng Yan, Xiao‐Jie Yu, Jian‐Wen Wang, Long‐Di Yao, De‐Yuan Fu   +10 more
wiley   +1 more source

Tumid lupus erythematosus in C1-inhibitor deficiency

Journal of the Royal College of Physicians of Edinburgh
A case of a 28-year-old woman with known C1-inhibitor deficiency (functional, Type II) with persistent bilateral non-pruritic, mildly photosensitive facial rash for 10 months following delivery of her second child is presented. Histology of the skin was suggestive of tumid lupus erythematosus (LE), but no other features of systemic LE (ANA, dsDNA ...
openaire   +2 more sources

Angioedema due to acquired C1 inhibitor deficiency: patient experience, conceptual disease model, and assessment of patient-reported outcome measures. [PDF]

Front Immunol
de Lange M, Cohn DM, Gobert D, Riedl MA, Zanichelli A, Brewer K, Clifford S, Pattanaik S, Romero B, Chen M, Mendivil J.   +10 more
europepmc   +1 more source

Clinical Characteristics and Management of Angioedema Attacks in Polish Adult Patients with Hereditary Angioedema Due to C1-Inhibitor Deficiency. [PDF]

J Clin Med, 2021
Piotrowicz-Wójcik K, Bulanda M, Juchacz A, Jamróz-Brzeska J, Gocki J, Kuziemski K, Pawłowicz R, Porebski G.   +7 more
europepmc   +1 more source

Subversion of Atypical Mucin Traps by a Spore‐Coat Effector Blocks Cellular Immunity in Drosophila

Advanced Science, EarlyView.
While the entomopathogenic fungus Metarhizium robertsii can evade insect humoral immunity, its subversion of cellular defenses is still elusive. We identify Eac1 as a spore‐coat protein essential for infecting drosophilids by targeting atypical mucins (Sgf1 and Sgf2), which can entrap spores in a gel matrix and thereby facilitate hemocyte encapsulation.
Shiqin Li, Haimin Chen, Gangqi Fang, Dongxiang Wei, Hongyun Wu, Chen Chen, Song Hong, Chengshu Wang   +7 more
wiley   +1 more source

Acquired Angioedema Related to Transient C1- Inhibitor Deficiency Triggered by <i>Mycoplasma pneumoniae</i> Infection: A Case Report. [PDF]

Reports (MDPI)
Peristeri AM, Akritidou O, Nikopoulou A, Theodoridou K, Leontakianakos M, Theocharidou CC, Pilianidis G.   +6 more
europepmc   +1 more source

How Angioedema Quality of Life Questionnaire Can Help Physicians in Treating C1-Inhibitor Deficiency Patients? [PDF]

Clin Rev Allergy Immunol, 2021
Balla Z, Ignácz B, Varga L, Kőhalmi KV, Farkas H.   +4 more
europepmc   +1 more source