Results 281 to 290 of about 70,452 (309)
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C1q binding and C1q deviation assays using enzyme labelled C1q
Journal of Immunological Methods, 1984Methods for the enzyme labelling of C1q are described. The C1q conjugates have been incorporated into suitably modified C1q deviation and C1q binding assays for circulating immune complexes. These assays show the expected high positivity rate in sera from patients with systemic lupus erythematosus.
G.W. Smith, I.J. Simpson, M.J. Myles
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RAGE binds C1q and enhances C1q-mediated phagocytosis
Cellular Immunology, 2012RAGE, the multiligand receptor of the immunoglobulin superfamily of cell surface molecules, is implicated in innate and adaptive immunity. Complement component C1q serves roles in complement activation and antibody-independent opsonization. Using soluble forms of RAGE (sRAGE) and RAGE-expressing cells, we determined that RAGE is a native C1q globular ...
Fei Song +5 more
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Pediatric Nephrology, 2005
C1q nephropathy (C1qNP) is a peculiar form of glomerulonephritis characterized by mesangial immunoglobulin and complement deposits, predominantly C1q, with no evidence of systemic lupus erythematosus. We describe the incidence, manifestation, histopathologic findings, follow-up, treatment and outcome of C1qNP.
Mojca Avguštin Čavić +5 more
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C1q nephropathy (C1qNP) is a peculiar form of glomerulonephritis characterized by mesangial immunoglobulin and complement deposits, predominantly C1q, with no evidence of systemic lupus erythematosus. We describe the incidence, manifestation, histopathologic findings, follow-up, treatment and outcome of C1qNP.
Mojca Avguštin Čavić +5 more
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Membranous nephropathy with predominance of C1q: another variant of C1q nephropathy?
Clinical Nephrology, 2012Originally described as a proliferative glomerulonephritis, C1q nephropathy is nowadays mostly recognized as a variant of focal segmental glomerulosclerosis or minimal change disease. We describe a 30-year-old male patient with nephrotic range proteinuria. Kidney biopsy demonstrated a membranous nephropathy with predominant staining for C1q.
Deurwaarder, E.S. den +3 more
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Autoimmunity Reviews, 2008
Autoantibodies to complement components are associated with various diseases. Anti-C1q antibodies are present in all patients with hypocomplementemic urticarial vasculitis, but also, with varying prevalence, in other conditions. In SLE, these antibodies are neither sensitive nor specific for this condition.
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Autoantibodies to complement components are associated with various diseases. Anti-C1q antibodies are present in all patients with hypocomplementemic urticarial vasculitis, but also, with varying prevalence, in other conditions. In SLE, these antibodies are neither sensitive nor specific for this condition.
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Isolation and characterization of maerophage‐derived C1q and its similarities to serum C1q
European Journal of Immunology, 1986AbstractRecently, we have shown that the collagen‐like, Fc‐recognizing subcomponent C1q of the first complement component is synthesized by human, guinea pig and mouse peritoneal macrophages. To test whether macrophages may contribute to the serum pool of C1q, C1q was purified from guinea pig serum and from guinea pig peritoneal macrophage supernatants
Hans-Peter Heinz +5 more
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Role of C1q and C1q Receptors in the Pathogenesis of Systemic Lupus Erythematosus
2003The association between C1q and autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus (SLE) is well established. Deficiency in C1q is considered to be a strong susceptibility factor and is corroborated by the fact that > or = 92% of the known cases of hereditary deficiency in C1q develop rheumatic disease.
Ellinor I.B. Peerschke +1 more
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Platelet C1q receptor interactions with collagen- and C1q-coated surfaces.
The Journal of Immunology, 1990Abstract We recently described specific binding sites for C1q on human blood platelets. Structural similarities between the amino-terminal of C1q and collagen have suggested that receptors for both molecules on platelets might be the same.
E I, Peerschke, B, Ghebrehiwet
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The binding site for C1q on IgG [PDF]
Nature, 1988 In humoral defence, pathogens are cleared by antibodies acting as adaptor molecules: they bind to antigen and trigger clearance mechanisms such as phagocytosis, antibody-dependent cell-mediated cytotoxicity and complement lysis. The first step in the complement cascade is the binding of C1q to the antibody.
Alexander R. Duncan, Greg Winter
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2007
Autoantibodies to C1q, which bind to epitopes on the collagen-like region (CLR) of the C1q molecule, are one of the best biomarkers of active, proliferative forms of lupus nephritis. Anti-C1q antibodies probably arise after immunization with neoantigens on C1q bound to immune complexes or to early apoptotic cells, and they play a pathogenic role in ...
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Autoantibodies to C1q, which bind to epitopes on the collagen-like region (CLR) of the C1q molecule, are one of the best biomarkers of active, proliferative forms of lupus nephritis. Anti-C1q antibodies probably arise after immunization with neoantigens on C1q bound to immune complexes or to early apoptotic cells, and they play a pathogenic role in ...
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