Results 291 to 300 of about 70,452 (309)
Some of the next articles are maybe not open access.
2019
Antibodies to components of the innate immune system are frequently detected in the sera of patients with systemic lupus erythematosus (SLE). Among these are antibodies against various components of the complement system. Antibodies to C1q have drawn particular attention as they have been suggested to be involved in the pathogenesis of lupus nephritis ...
De Leeuw, Karina, Kallenberg, Cees G.M.
openaire +2 more sources
Antibodies to components of the innate immune system are frequently detected in the sera of patients with systemic lupus erythematosus (SLE). Among these are antibodies against various components of the complement system. Antibodies to C1q have drawn particular attention as they have been suggested to be involved in the pathogenesis of lupus nephritis ...
De Leeuw, Karina, Kallenberg, Cees G.M.
openaire +2 more sources
C1q: A novel angiogenic factor?
Molecular Immunology, 2008We have recently shown that endothelial cells (ECs) isolated from human decidua synthesize C1q and express surface-bound C1q under physiological conditions [Bulla et al., 2008. Mol. Immunol.]. Since decidua is a typical site of vascular remodelling and active angiogenic process, we sought to ascertain whether C1q may play a role in promoting ...
BOSSI, FLEUR +7 more
openaire +3 more sources
Journal of Immunological Methods, 1984
The binding properties of C1q solid-phase radioimmunoassay (C1q SPRIA) were examined, using heat-aggregated IgG (HAG) as the model of immune complexes (IC). The free, liquid-phase C1q, which was added to the C1q-coated tubes prior to the addition of HAG, had little inhibitory effect on binding of HAG to the solid-phase C1q, suggesting that the solid ...
Shu Uwatoko +6 more
openaire +3 more sources
The binding properties of C1q solid-phase radioimmunoassay (C1q SPRIA) were examined, using heat-aggregated IgG (HAG) as the model of immune complexes (IC). The free, liquid-phase C1q, which was added to the C1q-coated tubes prior to the addition of HAG, had little inhibitory effect on binding of HAG to the solid-phase C1q, suggesting that the solid ...
Shu Uwatoko +6 more
openaire +3 more sources
2018
The first component of a complement is a pentameric complex comprising of C1q and the Ca2+-dependent tetramer C1r2C1s2. The roles of C1q within this complex are to recognise and bind immune complexes, as well as pathogen- or danger-associated molecular ligands, and trigger activation of the classical pathway of complement.
openaire +2 more sources
The first component of a complement is a pentameric complex comprising of C1q and the Ca2+-dependent tetramer C1r2C1s2. The roles of C1q within this complex are to recognise and bind immune complexes, as well as pathogen- or danger-associated molecular ligands, and trigger activation of the classical pathway of complement.
openaire +2 more sources
Isolation and characterization of mouse C1q
Journal of Immunological Methods, 1980C1q was isolated from mouse serum and ascites fluid by absorption onto human IgG-coated latex beads followed by separation on 3-10% exponential gradient sodium dodecyl sulfate (SDS) polyacrylamide gels. Mouse C1q was also purified by low ionic strength precipitation of mouse serum.
Paul K. Nakane, Linda M. McManus
openaire +3 more sources
Journal of Immunological Methods, 1991
A method for the detection of circulating immune complexes in the presence of autoantibodies to C1q is described. Solid phase C1q-digestion with bacterial collagenase results in the elimination of the collagen-like region of C1q. Binding of model immune complexes to this modified solid phase C1q is practically unaltered, while reactivity of anti-C1q ...
Fritz Gamerith +4 more
openaire +3 more sources
A method for the detection of circulating immune complexes in the presence of autoantibodies to C1q is described. Solid phase C1q-digestion with bacterial collagenase results in the elimination of the collagen-like region of C1q. Binding of model immune complexes to this modified solid phase C1q is practically unaltered, while reactivity of anti-C1q ...
Fritz Gamerith +4 more
openaire +3 more sources
2018
C1q, the recognition component of the classical complement pathway, also regulates numerous cellular processes independent of its role in complement activation. Among these processes is myeloid cell activation leading to enhanced engulfment of apoptotic cells and the regulation of proinflammatory cytokine production which is thought to be important in ...
openaire +2 more sources
C1q, the recognition component of the classical complement pathway, also regulates numerous cellular processes independent of its role in complement activation. Among these processes is myeloid cell activation leading to enhanced engulfment of apoptotic cells and the regulation of proinflammatory cytokine production which is thought to be important in ...
openaire +2 more sources
C1q levels in hereditary angioedema
Journal of Allergy and Clinical Immunology, 1977In 21 affected members from 4 kindreds with hereditary angioedema, serum C1q levels generally were in the lower part of the normal range, with some values clearly below the lower limit of normal. The serum C1q levels in patients with hereditary angioedema were significantly depressed when compared with those in unaffected family members (p less than 0 ...
openaire +3 more sources
THE ULTRASTRUCTURE OF HUMAN C1q [PDF]
Acta Pathologica Microbiologica Scandinavica Section B Microbiology and Immunology, 1970 Björn Bloth, Sven-Eric Svehag
openaire +2 more sources
2013
The classical complement pathway (CCP) activation is a multimolecular complex, composed of three subcomponents namely C1q, C1r, and C1s. C1q is the recognition subunit of this complex and its binding to the specific targets leads to the formation of active C1, which in turn activates the CCP in an immunoglobulin-dependent or -independent manner. C1q is
openaire +3 more sources
The classical complement pathway (CCP) activation is a multimolecular complex, composed of three subcomponents namely C1q, C1r, and C1s. C1q is the recognition subunit of this complex and its binding to the specific targets leads to the formation of active C1, which in turn activates the CCP in an immunoglobulin-dependent or -independent manner. C1q is
openaire +3 more sources