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Membranous nephropathy with predominance of C1q: another variant of C1q nephropathy?
Clinical Nephrology, 2012Originally described as a proliferative glomerulonephritis, C1q nephropathy is nowadays mostly recognized as a variant of focal segmental glomerulosclerosis or minimal change disease. We describe a 30-year-old male patient with nephrotic range proteinuria. Kidney biopsy demonstrated a membranous nephropathy with predominant staining for C1q.
Deurwaarder, E.S. den +3 more
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Autoimmunity Reviews, 2008
Autoantibodies to complement components are associated with various diseases. Anti-C1q antibodies are present in all patients with hypocomplementemic urticarial vasculitis, but also, with varying prevalence, in other conditions. In SLE, these antibodies are neither sensitive nor specific for this condition.
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Autoantibodies to complement components are associated with various diseases. Anti-C1q antibodies are present in all patients with hypocomplementemic urticarial vasculitis, but also, with varying prevalence, in other conditions. In SLE, these antibodies are neither sensitive nor specific for this condition.
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Isolation and characterization of maerophage‐derived C1q and its similarities to serum C1q
European Journal of Immunology, 1986AbstractRecently, we have shown that the collagen‐like, Fc‐recognizing subcomponent C1q of the first complement component is synthesized by human, guinea pig and mouse peritoneal macrophages. To test whether macrophages may contribute to the serum pool of C1q, C1q was purified from guinea pig serum and from guinea pig peritoneal macrophage supernatants
Hans-Peter Heinz +5 more
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Role of C1q and C1q Receptors in the Pathogenesis of Systemic Lupus Erythematosus
2003The association between C1q and autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus (SLE) is well established. Deficiency in C1q is considered to be a strong susceptibility factor and is corroborated by the fact that > or = 92% of the known cases of hereditary deficiency in C1q develop rheumatic disease.
Ellinor I.B. Peerschke +1 more
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Platelet C1q receptor interactions with collagen- and C1q-coated surfaces.
The Journal of Immunology, 1990Abstract We recently described specific binding sites for C1q on human blood platelets. Structural similarities between the amino-terminal of C1q and collagen have suggested that receptors for both molecules on platelets might be the same.
E I, Peerschke, B, Ghebrehiwet
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The binding site for C1q on IgG [PDF]
Nature, 1988 In humoral defence, pathogens are cleared by antibodies acting as adaptor molecules: they bind to antigen and trigger clearance mechanisms such as phagocytosis, antibody-dependent cell-mediated cytotoxicity and complement lysis. The first step in the complement cascade is the binding of C1q to the antibody.
Alexander R. Duncan, Greg Winter
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2007
Autoantibodies to C1q, which bind to epitopes on the collagen-like region (CLR) of the C1q molecule, are one of the best biomarkers of active, proliferative forms of lupus nephritis. Anti-C1q antibodies probably arise after immunization with neoantigens on C1q bound to immune complexes or to early apoptotic cells, and they play a pathogenic role in ...
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Autoantibodies to C1q, which bind to epitopes on the collagen-like region (CLR) of the C1q molecule, are one of the best biomarkers of active, proliferative forms of lupus nephritis. Anti-C1q antibodies probably arise after immunization with neoantigens on C1q bound to immune complexes or to early apoptotic cells, and they play a pathogenic role in ...
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2019
Antibodies to components of the innate immune system are frequently detected in the sera of patients with systemic lupus erythematosus (SLE). Among these are antibodies against various components of the complement system. Antibodies to C1q have drawn particular attention as they have been suggested to be involved in the pathogenesis of lupus nephritis ...
De Leeuw, Karina, Kallenberg, Cees G.M.
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Antibodies to components of the innate immune system are frequently detected in the sera of patients with systemic lupus erythematosus (SLE). Among these are antibodies against various components of the complement system. Antibodies to C1q have drawn particular attention as they have been suggested to be involved in the pathogenesis of lupus nephritis ...
De Leeuw, Karina, Kallenberg, Cees G.M.
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Journal of Immunological Methods, 1984
The binding properties of C1q solid-phase radioimmunoassay (C1q SPRIA) were examined, using heat-aggregated IgG (HAG) as the model of immune complexes (IC). The free, liquid-phase C1q, which was added to the C1q-coated tubes prior to the addition of HAG, had little inhibitory effect on binding of HAG to the solid-phase C1q, suggesting that the solid ...
Shu Uwatoko +6 more
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The binding properties of C1q solid-phase radioimmunoassay (C1q SPRIA) were examined, using heat-aggregated IgG (HAG) as the model of immune complexes (IC). The free, liquid-phase C1q, which was added to the C1q-coated tubes prior to the addition of HAG, had little inhibitory effect on binding of HAG to the solid-phase C1q, suggesting that the solid ...
Shu Uwatoko +6 more
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C1q: A novel angiogenic factor?
Molecular Immunology, 2008We have recently shown that endothelial cells (ECs) isolated from human decidua synthesize C1q and express surface-bound C1q under physiological conditions [Bulla et al., 2008. Mol. Immunol.]. Since decidua is a typical site of vascular remodelling and active angiogenic process, we sought to ascertain whether C1q may play a role in promoting ...
BOSSI, FLEUR +7 more
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