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2018
The first component of a complement is a pentameric complex comprising of C1q and the Ca2+-dependent tetramer C1r2C1s2. The roles of C1q within this complex are to recognise and bind immune complexes, as well as pathogen- or danger-associated molecular ligands, and trigger activation of the classical pathway of complement.
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The first component of a complement is a pentameric complex comprising of C1q and the Ca2+-dependent tetramer C1r2C1s2. The roles of C1q within this complex are to recognise and bind immune complexes, as well as pathogen- or danger-associated molecular ligands, and trigger activation of the classical pathway of complement.
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Isolation and characterization of mouse C1q
Journal of Immunological Methods, 1980C1q was isolated from mouse serum and ascites fluid by absorption onto human IgG-coated latex beads followed by separation on 3-10% exponential gradient sodium dodecyl sulfate (SDS) polyacrylamide gels. Mouse C1q was also purified by low ionic strength precipitation of mouse serum.
Paul K. Nakane, Linda M. McManus
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Detection of C1q-bearing immune complexes by a monoclonal anti-C1q ELISA system
Journal of Immunological Methods, 1987A monoclonal antibody directed against the collagenous portion of human C1q was used to detect C1q-bearing immune complexes in patients with rheumatic disorders. Sera of patients with rheumatoid arthritis, systemic lupus erythematosus (SLE), osteoarthritis, as well as normal human sera (NHS) used as controls were tested in an ELISA system.
Ursula Antes +2 more
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2018
C1q, the recognition component of the classical complement pathway, also regulates numerous cellular processes independent of its role in complement activation. Among these processes is myeloid cell activation leading to enhanced engulfment of apoptotic cells and the regulation of proinflammatory cytokine production which is thought to be important in ...
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C1q, the recognition component of the classical complement pathway, also regulates numerous cellular processes independent of its role in complement activation. Among these processes is myeloid cell activation leading to enhanced engulfment of apoptotic cells and the regulation of proinflammatory cytokine production which is thought to be important in ...
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C1q levels in hereditary angioedema
Journal of Allergy and Clinical Immunology, 1977In 21 affected members from 4 kindreds with hereditary angioedema, serum C1q levels generally were in the lower part of the normal range, with some values clearly below the lower limit of normal. The serum C1q levels in patients with hereditary angioedema were significantly depressed when compared with those in unaffected family members (p less than 0 ...
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THE ULTRASTRUCTURE OF HUMAN C1q [PDF]
Acta Pathologica Microbiologica Scandinavica Section B Microbiology and Immunology, 1970 Björn Bloth, Sven-Eric Svehag
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2013
The classical complement pathway (CCP) activation is a multimolecular complex, composed of three subcomponents namely C1q, C1r, and C1s. C1q is the recognition subunit of this complex and its binding to the specific targets leads to the formation of active C1, which in turn activates the CCP in an immunoglobulin-dependent or -independent manner. C1q is
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The classical complement pathway (CCP) activation is a multimolecular complex, composed of three subcomponents namely C1q, C1r, and C1s. C1q is the recognition subunit of this complex and its binding to the specific targets leads to the formation of active C1, which in turn activates the CCP in an immunoglobulin-dependent or -independent manner. C1q is
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Circulating complexes between C1q and anti-C1q in systemic lupus erythematosus
Molecular Immunology, 2008Dörte Hamann +3 more
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Interaction of C1q, and other proteins containing collagen-like domains, with the C1q receptor
Biochemical Society Transactions, 1990Kenneth B.M. Reid +2 more
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