Results 41 to 50 of about 2,290,523 (275)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The demographic, clinical, and management differences between traumatic dens fracture patients with and without simultaneous atlas fractures

Journal of Craniovertebral Junction and Spine
Introduction: Atlas fractures often accompany traumatic dens fractures, but existing literature on the management of simultaneous atlantoaxial fractures is limited.
Michael Brendan Cloney, Pavlos Texakalidis, Anastasios G Roumeliotis, Vineeth Thirunavu, Nathan A Shlobin, Kevin Swong, Najib El Tecle, Nader S Dahdaleh   +7 more
doaj   +1 more source

Muraymycin nucleoside-peptide antibiotics: uridine-derived natural products as lead structures for the development of novel antibacterial agents

Beilstein Journal of Organic Chemistry, 2016
Muraymycins are a promising class of antimicrobial natural products. These uridine-derived nucleoside-peptide antibiotics inhibit the bacterial membrane protein translocase I (MraY), a key enzyme in the intracellular part of peptidoglycan biosynthesis ...
Daniel Wiegmann, Stefan Koppermann, Marius Wirth, Giuliana Niro, Kristin Leyerer, Christian Ducho   +5 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Multinational Mission Command: From Paper to Practice in NATO

Scandinavian Journal of Military Studies
With the 2022 update to NATO’s AJP-01 Allied Joint Doctrine, mission command was elevated from an important component of a joint command philosophy to the alliance’s overarching command philosophy – a shift in written doctrine raising concerns about its ...
Søren Sjøgren, Niklas Nilsson
doaj   +1 more source

Enhanced Stability of DNA Oligonucleotides with Partially Zwitterionic Backbone Structures in Biological Media

Molecules, 2018
Deficient stability towards nuclease-mediated degradation is one of the most relevant tasks in the development of oligonucleotide-derived biomedical agents.
Melissa Meng, Boris Schmidtgall, Christian Ducho   +2 more
doaj   +1 more source

Non-Toxic Increases in Nitrogen Availability Can Improve the Ability of the Soil Lichen Cladonia rangiferina to Cope with Environmental Changes

Journal of Fungi, 2022
Climate change and atmospheric nitrogen (N) deposition on drylands are greatly threatening these especially vulnerable areas. Soil biocrust-forming lichens in drylands can provide early indicators of these disturbances and play a pivotal role, as they ...
Lourdes Morillas, Javier Roales, Cristina Cruz, Silvana Munzi   +3 more
doaj   +1 more source

Nernst Effect in Electron-Doped Pr$_{2-x}$Ce$_{x}$CuO$_4$ [PDF]

, 2003
The Nernst effect of Pr$_{2-x}$Ce$_{x}$CuO$_4$ (x=0.13, 0.15, and 0.17) has been measured on thin film samples between 5-120 K and 0-14 T. In comparison to recent measurements on hole-doped cuprates that showed an anomalously large Nernst effect above ...
A. Ino, A. Koitzsch, Amlan Biswas, B. Josephson, C. Capan, C. P. Hill, C.C. Homes, E. Helfand, E.H. Sondheimer, E.J. Singley, F. Gollnik, H.C. Ri, Hamza Balci, Hiroshi Kontani, Iddo Ussishkin, J.A. Clayhold, Jeffrey Clayhold, L. Alff, M. M. Qazilbash, M. Zeh, M.E. Simon, N.P. Armitage, N.P. Armitage, N.R. Werthamer, P. Fournier, R. L. Greene, S. Kleefisch, S.J. Hagen, Tom Timusk, V.E. Gasumyants, X. Jiang, Yayu Wang, Yayu Wang, Yayu Wang, Z.A. Xu   +34 more
core   +2 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Advantages of the point-intercept method for assessing functional diversity in semi-arid areas

iForest - Biogeosciences and Forestry, 2015
Semi-arid areas are particularly susceptible to the loss of biodiversity as a consequence of global change. Species functional traits are key drivers of functioning and resilience of ecosystems, thus monitoring of functional trait diversity is urgently ...
Nunes A, Tápia S, Pinho P, Correia O, Branquinho C   +4 more
doaj   +1 more source