Results 91 to 100 of about 4,044,136 (204)
Journal of Biological Chemistry, 2012 Background: PKCθ plays a key role in T lymphocyte activation, but its regulatory mechanism is not understood. Results: Phosphotyrosine binds the PKCθ C2 domain and activates PKCθ.
R. Stahelin +8 more
semanticscholar +1 more source
Structural basis for interdomain communication in SHIP2 providing high phosphatase activity
eLife, 2017 SH2-containing-inositol-5-phosphatases (SHIPs) dephosphorylate the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P3) and play important roles in regulating the PI3K/Akt pathway in physiology and disease.
Johanne Le Coq +7 more
doaj +1 more source
Disulfide Bonds within the C2 Domain of RAGE Play Key Roles in Its Dimerization and Biogenesis
PLoS ONE, 2012 Background The receptor for advanced glycation end products (RAGE) on the cell surface transmits inflammatory signals. A member of the immunoglobulin superfamily, RAGE possesses the V, C1, and C2 ectodomains that collectively constitute the receptor's ...
Wen Wei +9 more
semanticscholar +1 more source
Myc-binding Protein Orthologue Interacts with AKAP240 In the Central Pair Apparatus of the \u3cem\u3eChlamydomonas\u3c/em\u3e Flagella [PDF]
, 2016 Background Flagella and cilia are fine thread-like organelles protruding from cells that harbour them. The typical ‘9 + 2’ cilia confer motility on these cells.
Chowdhury, Twinkle S. +6 more
core +1 more source
Signaling through C2 domains: More than one lipid target
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2014 C2 domains are membrane-binding modules that share a common overall fold: a single compact Greek-key motif organized as an eight-stranded anti-parallel β-sandwich consisting of a pair of four-stranded β-sheets. A myriad of studies have demonstrated that in spite of sharing the common structural β-sandwich core, slight variations in the residues located
Corbalan-Garcia, Senena +1 more
openaire +2 more sources
Domain specific software architectures: Command and control [PDF]
GTE is the Command and Control contractor for the Domain Specific Software Architectures program. The objective of this program is to develop and demonstrate an architecture-driven, component-based capability for the automated generation of command and ...
Balzer, Bob +6 more
core +1 more source
F1000Research, 2018 The burden of chronic hepatitis B virus (HBV) infections is increasingly detected nowadays. Herein, we report a complete genome of HBV subgenotype C2 (HBV/C2) from a HBV infected patient.
Modhusudon Shaha +8 more
doaj +1 more source
Phosphatidylinositol-4,5-bisphosphate enhances anionic lipid demixing by the C2 domain of PKCα.
PLoS ONE, 2014 The C2 domain of PKCα (C2α) induces fluorescence self-quenching of NBD-PS in the presence of Ca2+, which is interpreted as the demixing of phosphatidylserine from a mixture of this phospholipid with phosphatidylcholine.
Antonio L Egea-Jiménez +5 more
doaj +1 more source
Monte Carlo Simulation of Ising Models with Dipole Interaction
, 1994 Recently, a new memory effect was found in the metamagnetic domain structure of the diluted Ising antiferromagnet $Fe_x Mg_{1-x} Cl_2$ by domain imaging with Faraday contrast. Essential for this effect is the dipole interaction.
A. Hucht +4 more
core +1 more source
Communicative & Integrative Biology, 2017 Synaptotagmin 1 (Syt 1) is an integral membrane protein responsible for sensing the calcium ion (Ca2+) influx in neurons that triggers synaptic vesicle exocytosis.
Michael E. Fealey +2 more
doaj +1 more source