Results 71 to 80 of about 683,642 (281)

The Dual Roles of MAGE-C2 in p53 Ubiquitination and Cell Proliferation Through E3 Ligases MDM2 and TRIM28

Frontiers in Cell and Developmental Biology, 2022
The tumor suppressor p53 is critical for the maintenance of genome stability and protection against tumor malignant transformation, and its homeostasis is usually regulated by ubiquitination.
Yunshan Liu, Beibei Cao, Liqiao Hu, Jingjing Ye, Wei Tian, Xiaojing He   +5 more
doaj   +1 more source

Microscopic theory of quadrupolar ordering in TmTe

, 2000
We have calculated the crystal electric field of TmTe (T>T_Q) and have obtained that the ground state of a Tm 4f hole is the $\Gamma_7$ doublet in agreement with Mossbauer experiments. We study the quadrupole interactions arising from quantum transitions
A. V. Nikolaev, A. V. Nikolaev, A. V. Nikolaev, A. V. Nikolaev, B. B. Triplett, C. J. Bradley, D. J. Newman, D. J. Newman, D. J. Singh, D. Lamoen, E. Bucher, E. Clementyev, G. V. Ionova, H. R. Ott, H. T. Stokes, H. Yasuda, J. Tang, J.-M. Mignot, J.-M. Mignot, K. H. Michel, K. H. Michel, K. H. Michel, K. Parlinski, K. R. Lea, K. W. H. Stevens, M. R. Norman, M. T. Hutchings, O. K. Andersen, O. V. Kovalev, P. Link, P. Link, P. Link, P. Wachter, R. Heid, R. M. Lynden-Bell, R. Shiina, R. Shiina, R. Suryanarayanan, S. E. Barnes, S. Heathman, T. Kasuya, T. Matsumura, T. Matsumura, T. Matsumura, T. Matsumura, Y. Lassailly   +45 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Redefining the architecture of ferlin proteins: Insights into multi-domain protein structure and function.

PLoS ONE, 2022
Ferlins are complex, multi-domain proteins, involved in membrane trafficking, membrane repair, and exocytosis. The large size of ferlin proteins and the lack of consensus regarding domain boundaries have slowed progress in understanding molecular-level ...
Matthew J Dominguez, Jon J McCord, R Bryan Sutton   +2 more
doaj   +1 more source

Non-relativistic Nambu-Goldstone modes associated with spontaneously broken space-time and internal symmetries [PDF]

, 2014
We show that a momentum operator of a translational symmetry may not commute with an internal symmetry operator in the presence of a topological soliton in non-relativistic theories. As a striking consequence, there appears a coupled Nambu-Goldstone mode
Kobayashi, Michikazu, Nitta, Muneto
core   +2 more sources

Structure of the C2 domain from novel protein kinase Cϵ. A membrane binding model for Ca2+-independent C2 domains

Journal of Molecular Biology, 2001
Protein kinase Cepsilon (PKCepsilon) is a member of the novel PKCs which are activated by acidic phospholipids, diacylglycerol and phorbol esters, but lack the calcium dependence of classical PKC isotypes. The crystal structures of the C2 domain of PKCepsilon, crystallized both in the absence and in the presence of the two acidic phospholipids, 1,2 ...
Ochoa, Wendy F., García-García, Josefa, Fita, Ignacio, Corbalán-García, Senena, Verdaguer, Núria, Gómez-Fernández, Juan C.   +5 more
openaire   +3 more sources

A Numerical–Experimental Approach for Multi‐Matrix Fiber‐Reinforced Plastics Characterization Using Finite Element Model Updating

Advanced Engineering Materials, EarlyView.
A numerical–experimental framework is developed for characterizing multi‐matrix fiber‐reinforced polymers (MM‐FRPs) combining epoxy and polyurethane matrices. Harmonic bending tests are integrated with finite element model updating (FEMU) to simultaneously identify elastic and viscoelastic material parameters.
Rodrigo M. Dartora, Tales V. Lisbôa, Axel Spickenheuer, Rogério J. Marczak, Jakson M. Vassoler   +4 more
wiley   +1 more source

Regulation of PKCα Activity by C1-C2 Domain Interactions [PDF]

Journal of Biological Chemistry, 2002
In this study, the role of interdomain interactions involving the C1 and C2 domains in the mechanism of activation of PKC was investigated. Using an in vitro assay containing only purified recombinant proteins and the phorbol ester, 4 beta-12-O-tetradecanoylphorbol-13-acetate (TPA), but lacking lipids, it was found that PKC alpha bound specifically ...
Simon J, Slater, Jodie L, Seiz, Anthony C, Cook, Christopher J, Buzas, Steve A, Malinowski, Jennifer L, Kershner, Brigid A, Stagliano, Christopher D, Stubbs   +7 more
openaire   +2 more sources

Additive Gaussian Process Regression for Predictive Design of High‐Performance, Printable Silicones

Advanced Engineering Materials, EarlyView.
A chemistry‐aware design framework for tuning printable polydimethylsiloxane (PDMS) for vat photopolymerization (VPP) is developed using additive Gaussian process (GP) modeling. Polymer network mechanics informs variable groupings, feasible formulation constraints, and interaction variables.
Roxana Carbonell, Martha Leach, Hongtao Song, Carolyn Seepersad   +3 more
wiley   +1 more source