Results 61 to 70 of about 683,642 (281)

NOD2-C2 - a novel NOD2 isoform activating NF-kappaB in a muramyl dipeptide-independent manner [PDF]

, 2010
Background The innate immune system employs several receptor families that form the basis of sensing pathogen-associated molecular patterns. NOD (nucleotide-binding and oligomerization domain) like receptors (NLRs) comprise a group of cytosolic proteins ...
Marcel Kramer, Janne Bock, Daniela Reichenbach, Christoph Kaether, Stefan Schreiber, Matthias Platzer, Philip Rosenstiel, Klaus Huse   +7 more
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Monte Carlo Simulation of Ising Models with Dipole Interaction

, 1994
Recently, a new memory effect was found in the metamagnetic domain structure of the diluted Ising antiferromagnet $Fe_x Mg_{1-x} Cl_2$ by domain imaging with Faraday contrast. Essential for this effect is the dipole interaction.
A. Hucht, Belanger D. P., Dillon J. F., Mattsson J., U. Nowak   +4 more
core   +1 more source

Guanylyl cyclase activity associated with putative bifunctional integral membrane proteins in Plasmodium falciparum. [PDF]

, 2000
We report here that guanylyl cyclase activity is associated with two large integral membrane proteins (PfGCalpha and PfGCbeta) in the human malaria parasite Plasmodium falciparum.
Altschul, Bakalyar, Baker, Bilker, Brooks, Bzik, Cavalier-Smith, Chinkers, Cowman, Defer, Devereaux, Don, Garbers, Gilman, Harte, Ishikawa, Janssens, Jencks, Kawamoto, Koch, Krupinsky, Li, Li, Li, Linder, Liu, MacLennan, Nakane, Pitt, Ripmaster, Robson, Sambrook, Sanchez, Saul, Schulkes, Schultz, Schultz, Sunahara, Sunahara, Tang, Taylor, Tesmer, Thaithong, Toyofuku, Triglia, Triglia, Triglia, Tucker, van Es, Walliker, Ward, Zhang, Zimmerman   +52 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Dysferlin forms a dimer mediated by the C2 domains and the transmembrane domain in vitro and in living cells. [PDF]

PLoS ONE, 2011
Dysferlin was previously identified as a key player in muscle membrane repair and its deficiency leads to the development of muscular dystrophy and cardiomyopathy. However, little is known about the oligomerization of this protein in the plasma membrane.
Li Xu, Sandeep Pallikkuth, Zhanjia Hou, Gregory A Mignery, Seth L Robia, Renzhi Han   +5 more
doaj   +1 more source

Domain regime in two-dimensional disordered vortex matter

, 2004
A detailed numerical study of the real space configuration of vortices in disordered superconductors using 2D London-Langevin model is presented. The magnetic field $B$ is varied between 0 and $B_{c2}$ for various pinning strengths $\Delta$.
A. Greiner, A.E. Koshelev, A.I. Larkin, C. Zeng, D. Carpentier, D. Carpentier, D. Ertaş, D.G. Grier, D.R. Nelson, D.S. Fisher, D.S. Fisher, E.H. Brandt, G. Blatter, G. T. Zimányi, I. Joumard, J. Toner, J.R. Clem, M. Kardar, M. Marchevsky, M. Menghini, M. Nicodemi, M.J.P. Gingras, M.V. Feigel’man, Mahesh Chandran, Mahesh Chandran, Min-Chul Cha, Min-Chul Cha, P. Le Doussal, R. Seshadri, R. T. Scalettar, S. Bogner, S. Ryu, S.E. Korshunov, T. Emig, T. Giamarchi, T. Giamarchi, T. Giamarchi, T. Klein, T. Nattermann, T. Nattermann, T. Nattermann, T. Tlusty, V. Vinokur, W. Henderson, X.S. Ling, Y. Fasano, Y. Paltiel   +46 more
core   +1 more source

Calculating the Potential of C2 Domains for Membrane Binding [PDF]

Developmental Cell, 2002
A recent report in Molecular Cell demonstrates the ability of electrostatic calculations to predict the membrane binding properties of structurally characterized C2 domains and assign probable membrane targeting functions to numerous uncharacterized C2 domains.
Merithew, Eric Lee, Lambright, David G.
openaire   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Modelling the Full-Length Inactive PKC-δ Structure to Explore Regulatory Accessibility and Selective Targeting Opportunities

Pharmaceuticals
Background/Objectives: Protein kinase C-δ (PKC-δ) is a pivotal regulator of cellular signalling, and its dysregulation contributes to oncogenesis. While certain isolated PKC-δ domains have been crystallised, the full-length architecture and interdomain ...
Rasha Khader, Lodewijk V. Dekker
doaj   +1 more source