Results 61 to 70 of about 157,920 (289)

Modelling the Full-Length Inactive PKC-δ Structure to Explore Regulatory Accessibility and Selective Targeting Opportunities

Pharmaceuticals
Background/Objectives: Protein kinase C-δ (PKC-δ) is a pivotal regulator of cellular signalling, and its dysregulation contributes to oncogenesis. While certain isolated PKC-δ domains have been crystallised, the full-length architecture and interdomain ...
Rasha Khader, Lodewijk V. Dekker
doaj   +1 more source

Additive Gaussian Process Regression for Predictive Design of High‐Performance, Printable Silicones

Advanced Engineering Materials, EarlyView.
A chemistry‐aware design framework for tuning printable polydimethylsiloxane (PDMS) for vat photopolymerization (VPP) is developed using additive Gaussian process (GP) modeling. Polymer network mechanics informs variable groupings, feasible formulation constraints, and interaction variables.
Roxana Carbonell, Martha Leach, Hongtao Song, Carolyn Seepersad   +3 more
wiley   +1 more source

PS membrane and PS-bound fVIII C2 ELISA results for factor VIII C2 domain variants and inhibitory antibodies.

, 2015
(A) Comparison of human (open circles) and porcine (closed squares) factor VIII C2 domains binding to PS membrane surfaces. (B) Comparison of human factor VIII C2 domain (open circles) with the human K2227A C2 domain mutant (closed squares).
Steven M. Mullen (702761), Caileen M. Brison (702760), Kira Podolsky (702763), Jacob A. Herman (702765), P. Clint Spiegel (702767), Justin D. Walter (702766), Michelle E. Wuerth (702762), Shannon L. Meeks (124024), Matthew Cook (702764)   +8 more
core   +1 more source

Microstructure Evolution of a VMnFeCoNi High‐Entropy Alloy After Synthesis, Swaging, and Annealing

Advanced Engineering Materials, EarlyView.
The synthesis and processing (rotary swaging and annealing) of the novel VMnFeCoNi alloy is investigated, alongside the estimation of the grain size effect on hardness. Analysis of a wide grain size range of recrystallized microstructures (12–210 µm) reveals a low annealing twin density.
Aditya Srinivasan Tirunilai, Zeki Ayrildi, Buse Şen, Maik Rajkowski, Mathias Redondo Garcia, Markus Stricker, Guillaume Laplanche   +6 more
wiley   +1 more source

The Dual Roles of MAGE-C2 in p53 Ubiquitination and Cell Proliferation Through E3 Ligases MDM2 and TRIM28

Frontiers in Cell and Developmental Biology, 2022
The tumor suppressor p53 is critical for the maintenance of genome stability and protection against tumor malignant transformation, and its homeostasis is usually regulated by ubiquitination.
Yunshan Liu, Beibei Cao, Liqiao Hu, Jingjing Ye, Wei Tian, Xiaojing He   +5 more
doaj   +1 more source

Protein Kinase C-Delta C2 Domain Interactions in Breast Cancer

, 2023
The role of protein kinase C-δ (PKC-δ) in breast cancer has been a major focus for a while. PKC-δ expression correlates negatively with the prognosis of breast cancer, and high PKC-δ expression was associated with reduced relapse-free survival in ...
Khader, Rasha
core  

Creep‐Induced Microstructural Evolution in an A2‐B2 Superalloy

Advanced Engineering Materials, EarlyView.
A 27.3Ta‐27.3Mo‐27.3Ti‐8Cr‐10Al (at.%) refractory high‐entropy alloy with precipitation‐strengthened A2‐B2 microstructure was studied by creep tests at 1030°C, which demonstrate a transition in deformation mechanisms in the range of 100–150 MPa applied stress. This is associated with changes in dislocation–precipitate interactions. Relevant deformation
Liu Yang, Aparajita Pramanik, Sandipan Sen, Shubhashis Dixit, Marcel Muench, R. J. Vikram, Daniel Schliephake, Yolita M. Eggeler, Ankur Chauhan, Martin Heilmaier, Alexander Kauffmann   +10 more
wiley   +1 more source

Phosphorylation modification reverses the transcriptional inhibitory activity of CsMYB4a in tea plants (Camellia sinensis)

Horticultural Plant Journal
The members of the fourth subgroup of R2R3-MYB (Sg4 members) are well-known inhibitors of phenylpropanoid and lignin synthesis pathways. The C2 domain is closely related to the transcriptional inhibitory activity of Sg4 members.
Guoliang Ma, Yunyun Han, Tongtong Li, Tao Xia, Liping Gao   +4 more
doaj   +1 more source

Redefining the architecture of ferlin proteins: Insights into multi-domain protein structure and function.

PLoS ONE, 2022
Ferlins are complex, multi-domain proteins, involved in membrane trafficking, membrane repair, and exocytosis. The large size of ferlin proteins and the lack of consensus regarding domain boundaries have slowed progress in understanding molecular-level ...
Matthew J Dominguez, Jon J McCord, R Bryan Sutton   +2 more
doaj   +1 more source

From Shear to Sound: Mechanics–Acoustics Mapping of TPMS Lattices

Advanced Engineering Materials, EarlyView.
Triply periodic minimal surface (TPMS) lattices are mapped across mechanical and acoustic performance, revealing that descriptors validated in compression fail under shear. First‐time comparison with trusses included. A transition from porous to resonance‐driven absorption emerges at 25% density.
Lucía Doyle, María Ángeles Navacerrada, Johan Christensen, Carlos González   +3 more
wiley   +1 more source