Results 41 to 50 of about 2,154,580 (280)
The role of phosphatidylserine on the membrane in immunity and blood coagulation
Biomarker Research, 2022 The negatively charged aminophospholipid, phosphatidylserine (PtdSer), is located in the inner leaflet of the plasma membrane in normal cells, and may be exposed to the outer leaflet under some immune and blood coagulation processes.
Jiao Wang +10 more
doaj +1 more source
Journal of Microbiology, Immunology and Infection, 2023 Background: Invasion of red blood cells by Plasmodium falciparum merozoites is governed by multiple receptor–ligand interactions which are critical for bridging the two cells together.
Akshay Munjal +2 more
doaj +1 more source
C2‐domain containing calcium sensors in neuroendocrine secretion [PDF]
Journal of Neurochemistry, 2016 The molecular mechanisms for calcium‐triggered membrane fusion have long been sought for, and detailed models now exist that account for at least some of the functions of the many proteins involved in the process. Key players in the fusion reaction are a group of proteins that, upon binding to calcium, trigger the merger of cargo‐filled vesicles with ...
Pinheiro, Paulo S +2 more
openaire +3 more sources
Infrared Spectroscopic Characterization of cPLA2Á C2 Domain
, 2014 Group IV cytosolic phospholipase A2Á (cPLAZÁ) hydrolyzes membrane phospholipids to produce arachidonic acid and lysolipid. The C2 domain of the enzyme is involved in the Ca2+ dependent translocation of the enzyme to the membrane and has a structure of 8 ...
Sun, Yunqiu
core +3 more sources
DUF581 is plant specific FCS-like zinc finger involved in protein-protein interaction. [PDF]
PLoS ONE, 2014 Zinc fingers are a ubiquitous class of protein domain with considerable variation in structure and function. Zf-FCS is a highly diverged group of C2-C2 zinc finger which is present in animals, prokaryotes and viruses, but not in plants.
Muhammed Jamsheer K, Ashverya Laxmi
doaj +1 more source
Calcium triggers an intramolecular association of the C2 domains in synaptotagmin [PDF]
Proceedings of the National Academy of Sciences, 2000 Synaptotagmin I is a critical component of the synaptic machinery that senses calcium influx and triggers synaptic vesicle fusion and neurotransmitter release. Fluorescence resonance energy transfer studies conducted on synaptotagmin demonstrate that calcium concentrations required for fusion induce a conformational change (EC
R A, García, C E, Forde, H A, Godwin
openaire +2 more sources
BMC Cell Biology, 2009 Background Ubiquitination serves multiple cellular functions, including proteasomal degradation and the control of stability, function, and intracellular localization of a wide variety of proteins.
Lalouel Jean-Marc +4 more
doaj +1 more source
Schematic of Type-II C2 domain.
, 2022 A: Dysferlin C2A structure (4IHB) colored to highlighted the various insertions of subdomains. B:The schematic highlights the loops with embedded subdomains. The Type-2 C2 domain β-strand topology is shown as grey arrows.
Jon J. McCord (11977550) +2 more
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source