Results 21 to 30 of about 157,972 (251)
Frontiers in Immunology, 2022 The complement system is one of the first defense lines protecting from invading pathogens. However, it may turn offensive to the body’s own cells and tissues when deregulated by the presence of rare genetic variants that impair physiological regulation ...
Alicja Kuźniewska +12 more
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The molecular basis of ceramide-1-phosphate recognition by C2 domains[S]
Journal of Lipid Research, 2013 Group IVA cytosolic phospholipase A2 (cPLA2α), which harbors an N-terminal lipid binding C2 domain and a C-terminal lipase domain, produces arachidonic acid from the sn-2 position of zwitterionic lipids such as phosphatidylcholine. The C2 domain has been
Katherine E. Ward +5 more
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Ferlins and TgDOC2 in Toxoplasma Microneme, Rhoptry and Dense Granule Secretion
Life, 2021 The host cell invasion process of apicomplexan parasites like Toxoplasma gondii is facilitated by sequential exocytosis of the microneme, rhoptry and dense granule organelles. Exocytosis is facilitated by a double C2 domain (DOC2) protein family.
Daniel N. A. Tagoe +5 more
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Electrostatic Control of the Membrane Targeting of C2 Domains [PDF]
Molecular Cell, 2002 Many proteins involved in signal transduction and vesicle trafficking contain C2 domains whose membrane association is often regulated by calcium. Here, finite-difference Poisson-Boltzmann calculations are used to describe the electrostatic interactions between C2 domains of known structure and phospholipid membranes.
Murray, Diana, Honig, Barry
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Centriolar Protein C2cd3 Is Required for Craniofacial Development
Frontiers in Cell and Developmental Biology, 2021 The primary cilium is a ubiquitous, microtubule-based cellular organelle. Primary cilia dysfunction results in a group of disorders termed ciliopathies. C2 domain containing 3 centriole elongation regulator (C2cd3), encodes a centriolar protein essential
Ching-Fang Chang +9 more
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Structure and Biochemistry of otoferlin C2-domains [PDF]
, 2022 Since the necessity of functional otoferlin for normal hearing has been discovered, the role of this protein in inner hair cell exocytosis is subject of intense studies. In this thesis, the crystal structure of the most N-terminal C2-domain of otoferlin, Otof-C2A, was solved and analyzed.
Helfmann, Sarah +5 more
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Frontiers in Molecular Biosciences, 2022 At sites of vascular damage, factor VIII (fVIII) is proteolytically activated by thrombin and binds to activated platelet surfaces with activated factor IX (fIXa) to form the intrinsic “tenase” complex. Previous structural and mutational studies of fVIII
Shaun C. Peters +9 more
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Superdiffusive motion of membrane-targeting C2 domains [PDF]
Scientific Reports, 2015 AbstractMembrane-targeting domains play crucial roles in the recruitment of signalling molecules to the plasma membrane. For most peripheral proteins, the protein-to-membrane interaction is transient. After proteins dissociate from the membrane they have been observed to rebind following brief excursions in the bulk solution.
Grace Campagnola +4 more
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Calculating the Potential of C2 Domains for Membrane Binding [PDF]
Developmental Cell, 2002 A recent report in Molecular Cell demonstrates the ability of electrostatic calculations to predict the membrane binding properties of structurally characterized C2 domains and assign probable membrane targeting functions to numerous uncharacterized C2 domains.
Merithew, Eric Lee, Lambright, David G.
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Membranes, 2022 Membrane proteins are broadly classified as transmembrane (TM) or peripheral, with functions that pertain to only a single bilayer at a given time. Here, we explicate a class of proteins that contain both transmembrane and peripheral domains, which we ...
Michael Overduin +4 more
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