Results 21 to 30 of about 683,642 (281)

Lipid binding domains: more than simple lipid effectors

Journal of Lipid Research, 2009
The spatial and temporal regulation of lipid molecules in cell membranes is a hallmark of cellular signaling and membrane trafficking events. Lipid-mediated targeting provides for strict control and versatility, because cell membranes harbor a large ...
Robert V. Stahelin
doaj   +1 more source

Distinctive phosphoinositide- and Ca²⁺-binding properties of normal and cognitive performance–linked variant forms of KIBRA C2 domain [PDF]

, 2018
Kidney- and brain-expressed protein (KIBRA), a multifunctional scaffold protein with around 20 known binding partners, is involved in memory and cognition, organ size control via the Hippo pathway, cell polarity, and membrane trafficking.
Bagby, S, Crennell, SJ, Harris, G, Ishima, R, Kalli, AC, Kremerskothen, J, Posner, MG, Sansom, MSP, Upadhyay, A   +8 more
core   +2 more sources

The C2 Domain of PKCδ Is a Phosphotyrosine Binding Domain [PDF]

Cell, 2005
In eukaryotic cells, the SH2 and PTB domains mediate protein-protein interactions by recognizing phosphotyrosine residues on target proteins. Here we make the unexpected finding that the C2 domain of PKCdelta directly binds to phosphotyrosine peptides in a sequence-specific manner. We provide evidence that this domain mediates PKCdelta interaction with
Benes, Cyril H., Wu, Ning, Elia, Andrew E.H., Dharia, Tejal, Cantley, Lewis C., Soltoff, Stephen P.   +5 more
openaire   +2 more sources

Substitutions at position 263 within the von Willebrand factor type A domain determine the functionality of complement C2 protein

Frontiers in Immunology, 2022
The complement system is one of the first defense lines protecting from invading pathogens. However, it may turn offensive to the body’s own cells and tissues when deregulated by the presence of rare genetic variants that impair physiological regulation ...
Alicja Kuźniewska, Marcel Thiel, Daria Kowalska, Anna Felberg-Miętka, Patryk Szynkowski, Stanisław Ołdziej, Emilia Arjona, Ilse Jongerius, Ilse Jongerius, Santiago Rodriguez de Córdoba, Marcin Okrój, Aleksandra Urban, Aleksandra Urban   +12 more
doaj   +1 more source

The molecular basis of ceramide-1-phosphate recognition by C2 domains[S]

Journal of Lipid Research, 2013
Group IVA cytosolic phospholipase A2 (cPLA2α), which harbors an N-terminal lipid binding C2 domain and a C-terminal lipase domain, produces arachidonic acid from the sn-2 position of zwitterionic lipids such as phosphatidylcholine. The C2 domain has been
Katherine E. Ward, Nitin Bhardwaj, Mohsin Vora, Charles E. Chalfant, Hui Lu, Robert V. Stahelin   +5 more
doaj   +1 more source

Ferlins and TgDOC2 in Toxoplasma Microneme, Rhoptry and Dense Granule Secretion

Life, 2021
The host cell invasion process of apicomplexan parasites like Toxoplasma gondii is facilitated by sequential exocytosis of the microneme, rhoptry and dense granule organelles. Exocytosis is facilitated by a double C2 domain (DOC2) protein family.
Daniel N. A. Tagoe, Allison A. Drozda, Julia A. Falco, Tyler J. Bechtel, Eranthie Weerapana, Marc-Jan Gubbels   +5 more
doaj   +1 more source

Centriolar Protein C2cd3 Is Required for Craniofacial Development

Frontiers in Cell and Developmental Biology, 2021
The primary cilium is a ubiquitous, microtubule-based cellular organelle. Primary cilia dysfunction results in a group of disorders termed ciliopathies. C2 domain containing 3 centriole elongation regulator (C2cd3), encodes a centriolar protein essential
Ching-Fang Chang, Ching-Fang Chang, Kari M. Brown, Kari M. Brown, Yanfen Yang, Yanfen Yang, Samantha A. Brugmann, Samantha A. Brugmann, Samantha A. Brugmann, Samantha A. Brugmann   +9 more
doaj   +1 more source

Critical thermodynamics of three-dimensional chiral model for N > 3 [PDF]

, 2003
The critical behavior of the three-dimensional $N$-vector chiral model is studied for arbitrary $N$. The known six-loop renormalization-group (RG) expansions are resummed using the Borel transformation combined with the conformal mapping and Pad\'e ...
A. I. Sokolov, A. Lascialfari, A. Peles, A. Pelissetto, A. Pelissetto, A. Pelissetto, A. Pelissetto, A. Pelissetto, D. Loison, D. Loison, E. H. Boubchear, G. Parisi, G. Zumbach, H. K. Janssen, H. Kadowaki, H. Kadowaki, H. Kawamura, H. Kawamura, H. Kawamura, H. Kawamura, J. A. Gracey, J. A. Gracey, J. C. Le Guillou, J. C. Le Guillou, J. M. Carmona, M. F. Collins, M. Fiebig, M. Itakura, M. Kukovic, M. Tissier, M. Tissier, M. Tissier, P. Azaria, P. Azaria, P. Calabrese, P. Calabrese, P. Calabrese, P. Calabrese, P. Parruccini, R. Folk, S. A. Antonenko, S. A. Antonenko, S. Sachdev, S. Sachdev, T. E. Mason, V. P. Plakhty, V. P. Plakhty, Y. Ajiro   +47 more
core   +1 more source

The C2 domain augments Ras GTPase-activating protein catalytic activity. [PDF]

Proc Natl Acad Sci U S A
Regulation of Ras GTPases by GTPase-activating proteins (GAPs) is essential for their normal signaling. Nine of the ten GAPs for Ras contain a C2 domain immediately proximal to their canonical GAP domain, and in RasGAP (p120GAP, p120RasGAP; RASA1 ) mutation of this domain is associated with ...
Paul ME, Chen D, Vish KJ, Lartey NL, Hughes E, Freeman ZT, Saunders TL, Stiegler AL, King PD, Boggon TJ.   +9 more
europepmc   +3 more sources

MCTP is an ER-resident calcium sensor that stabilizes synaptic transmission and homeostatic plasticity. [PDF]

, 2017
Presynaptic homeostatic plasticity (PHP) controls synaptic transmission in organisms from Drosophila to human and is hypothesized to be relevant to the cause of human disease.
Davis, Graeme W, Dickman, Dion K, Fetter, Richard D, Genç, Özgür, Ma, Wenpei, Tong, Amy   +5 more
core   +2 more sources