Results 11 to 20 of about 157,972 (251)

Structural basis of phosphatidylcholine recognition by the C2–domain of cytosolic phospholipase A2α [PDF]

eLife, 2019
Ca2+-stimulated translocation of cytosolic phospholipase A2α (cPLA2α) to the Golgi induces arachidonic acid production, the rate-limiting step in pro-inflammatory eicosanoid synthesis.
Yoshinori Hirano, Yong-Guang Gao, Daniel J Stephenson, Ngoc T Vu, Lucy Malinina, Dhirendra K Simanshu, Charles E Chalfant, Dinshaw J Patel, Rhoderick E Brown   +8 more
doaj   +2 more sources

The 1.7 Å X-ray crystal structure of the porcine factor VIII C2 domain and binding analysis to anti-human C2 domain antibodies and phospholipid surfaces. [PDF]

PLoS ONE, 2015
The factor VIII C2 domain is essential for binding to activated platelet surfaces as well as the cofactor activity of factor VIII in blood coagulation. Inhibitory antibodies against the C2 domain commonly develop following factor VIII replacement therapy
Caileen M Brison, Steven M Mullen, Michelle E Wuerth, Kira Podolsky, Matthew Cook, Jacob A Herman, Justin D Walter, Shannon L Meeks, P Clint Spiegel   +8 more
doaj   +2 more sources

Membrane binding and lipid-protein interaction of the C2 domain from coagulation factor V [PDF]

Current Research in Structural Biology
Anchoring of coagulation factors to anionic regions of the membrane involves the C2 domain as a key player. The rate of enzymatic reactions of the coagulation factors is increased by several orders of magnitude upon membrane binding. However, the precise
Y. Zenmei Ohkubo, Peter W. Radulovic, Albert N. Kahira, Jesper J. Madsen   +3 more
doaj   +2 more sources

Pancreatic β-cells package double C2-like domain beta protein into extracellular vesicles via tandem C2 domains

Frontiers in Endocrinology
IntroductionDouble C2-like domain beta (DOC2B) is a vesicle priming protein critical for glucose-stimulated insulin secretion in β-cells. Individuals with type 1 diabetes (T1D) have lower levels of DOC2B in their residual functional β-cell mass and ...
Diana Esparza, Carinna Lima, Sarah Abuelreich, Ima Ghaeli, Jinhee Hwang, Eunjin Oh, Ayelet Lenz, Angel Gu, Nan Jiang, Fouad Kandeel, Debbie C. Thurmond, Tijana Jovanovic-Talisman   +11 more
doaj   +3 more sources

The C2 Domain of PKCδ Is a Phosphotyrosine Binding Domain [PDF]

Cell, 2005
In eukaryotic cells, the SH2 and PTB domains mediate protein-protein interactions by recognizing phosphotyrosine residues on target proteins. Here we make the unexpected finding that the C2 domain of PKCdelta directly binds to phosphotyrosine peptides in a sequence-specific manner. We provide evidence that this domain mediates PKCdelta interaction with
Benes, Cyril H., Wu, Ning, Elia, Andrew E.H., Dharia, Tejal, Cantley, Lewis C., Soltoff, Stephen P.   +5 more
openaire   +2 more sources

A novel human TPIP splice-variant (TPIP-C2) mRNA, expressed in human and mouse tissues, strongly inhibits cell growth in HeLa cells. [PDF]

PLoS ONE, 2011
Alternative splicing of mRNAs is known to involve a major regulation of gene expression at RNA level in mammalian cells. The PTEN (Phosphatase and TENsin homologue deleted from the human chromosome 10), TPTE (Transmembrane Phosphatase with TEnsin ...
Rasmi Rekha Mishra, Jitendra Kumar Chaudhary, Gagan Deep Bajaj, Pramod C Rath   +3 more
doaj   +1 more source

Functions of Vertebrate Ferlins

Cells, 2020
Ferlins are multiple-C2-domain proteins involved in Ca2+-triggered membrane dynamics within the secretory, endocytic and lysosomal pathways. In bony vertebrates there are six ferlin genes encoding, in humans, dysferlin, otoferlin, myoferlin, Fer1L5 and 6
Anna V. Bulankina, Sven Thoms
doaj   +1 more source

C2 domain membrane penetration by group IVA cytosolic phospholipase A2 induces membrane curvature changes[S]

Journal of Lipid Research, 2012
Group IVA cytosolic phospholipase A2 (cPLA2α) is an 85 kDa enzyme that regulates the release of arachidonic acid (AA) from the sn-2 position of membrane phospholipids.
Katherine E. Ward, James P. Ropa, Emmanuel Adu-Gyamfi, Robert V. Stahelin   +3 more
doaj   +1 more source

Role of the plant-specific calcium-binding C2-DOMAIN ABSCISIC ACID-RELATED (CAR) protein family in environmental signaling

European Journal of Cell Biology, 2023
Many signaling processes rely on information decoding at the plasma membrane, and membrane-associated proteins and their complexes are fundamental for regulating this process.
Mingming Cui, Shishir K. Gupta, Petra Bauer   +2 more
doaj   +1 more source

Lipid binding domains: more than simple lipid effectors

Journal of Lipid Research, 2009
The spatial and temporal regulation of lipid molecules in cell membranes is a hallmark of cellular signaling and membrane trafficking events. Lipid-mediated targeting provides for strict control and versatility, because cell membranes harbor a large ...
Robert V. Stahelin
doaj   +1 more source