Results 11 to 20 of about 683,642 (281)
Ring-like oligomers of Synaptotagmins and related C2 domain proteins [PDF]
eLife, 2016 We recently reported that the C2AB portion of Synaptotagmin 1 (Syt1) could self-assemble into Ca2+-sensitive ring-like oligomers on membranes, which could potentially regulate neurotransmitter release.
Maria N Zanetti +7 more
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Membrane binding and lipid-protein interaction of the C2 domain from coagulation factor V [PDF]
Current Research in Structural BiologyAnchoring of coagulation factors to anionic regions of the membrane involves the C2 domain as a key player. The rate of enzymatic reactions of the coagulation factors is increased by several orders of magnitude upon membrane binding. However, the precise
Y. Zenmei Ohkubo +3 more
doaj +2 more sources
Frontiers in EndocrinologyIntroductionDouble C2-like domain beta (DOC2B) is a vesicle priming protein critical for glucose-stimulated insulin secretion in β-cells. Individuals with type 1 diabetes (T1D) have lower levels of DOC2B in their residual functional β-cell mass and ...
Diana Esparza +11 more
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C2 domain plays critical roles in localization of novel C2 domain-containing protein OsC2DP. [PDF]
Plant Signal Behav, 2019 OsC2DP is a cytosolic protein containing a C2 domain recently identified in rice, which is translocated to the plasma membrane in response to salt stress. Here, we further investigated the subcellular localization of OsC2DP by truncation analysis. In consistent with OsC2DP, OsC2DP1-165 containing C2 domain at the N-terminus was localized to the cytosol.
Fu S, Huang J, Chen Z, Xia J.
europepmc +4 more sources
The Role of C2 Domains in Two Different Phosphatases: PTEN and SHIP2
Membranes, 2023 Phosphatase and tensin homologue (PTEN) and SH2-containing inositol 5′-phosphatase 2 (SHIP2) are structurally and functionally similar. They both consist of a phosphatase (Ptase) domain and an adjacent C2 domain, and both proteins dephosphorylate ...
Laura H. John +3 more
doaj +1 more source
A novel human TPIP splice-variant (TPIP-C2) mRNA, expressed in human and mouse tissues, strongly inhibits cell growth in HeLa cells. [PDF]
PLoS ONE, 2011 Alternative splicing of mRNAs is known to involve a major regulation of gene expression at RNA level in mammalian cells. The PTEN (Phosphatase and TENsin homologue deleted from the human chromosome 10), TPTE (Transmembrane Phosphatase with TEnsin ...
Rasmi Rekha Mishra +3 more
doaj +1 more source
Functions of Vertebrate Ferlins
Cells, 2020 Ferlins are multiple-C2-domain proteins involved in Ca2+-triggered membrane dynamics within the secretory, endocytic and lysosomal pathways. In bony vertebrates there are six ferlin genes encoding, in humans, dysferlin, otoferlin, myoferlin, Fer1L5 and 6
Anna V. Bulankina, Sven Thoms
doaj +1 more source
Journal of Lipid Research, 2012 Group IVA cytosolic phospholipase A2 (cPLA2α) is an 85 kDa enzyme that regulates the release of arachidonic acid (AA) from the sn-2 position of membrane phospholipids.
Katherine E. Ward +3 more
doaj +1 more source
European Journal of Cell Biology, 2023 Many signaling processes rely on information decoding at the plasma membrane, and membrane-associated proteins and their complexes are fundamental for regulating this process.
Mingming Cui +2 more
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Superdiffusive motion of membrane-targeting C2 domains [PDF]
Scientific Reports, 2015 AbstractMembrane-targeting domains play crucial roles in the recruitment of signalling molecules to the plasma membrane. For most peripheral proteins, the protein-to-membrane interaction is transient. After proteins dissociate from the membrane they have been observed to rebind following brief excursions in the bulk solution.
Grace Campagnola +4 more
openaire +3 more sources