Results 31 to 40 of about 2,154,580 (280)
Ferlins and TgDOC2 in Toxoplasma Microneme, Rhoptry and Dense Granule Secretion
Life, 2021 The host cell invasion process of apicomplexan parasites like Toxoplasma gondii is facilitated by sequential exocytosis of the microneme, rhoptry and dense granule organelles. Exocytosis is facilitated by a double C2 domain (DOC2) protein family.
Daniel N. A. Tagoe +5 more
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Electrostatic Control of the Membrane Targeting of C2 Domains [PDF]
Molecular Cell, 2002 Many proteins involved in signal transduction and vesicle trafficking contain C2 domains whose membrane association is often regulated by calcium. Here, finite-difference Poisson-Boltzmann calculations are used to describe the electrostatic interactions between C2 domains of known structure and phospholipid membranes.
Murray, Diana, Honig, Barry
openaire +2 more sources
Centriolar Protein C2cd3 Is Required for Craniofacial Development
Frontiers in Cell and Developmental Biology, 2021 The primary cilium is a ubiquitous, microtubule-based cellular organelle. Primary cilia dysfunction results in a group of disorders termed ciliopathies. C2 domain containing 3 centriole elongation regulator (C2cd3), encodes a centriolar protein essential
Ching-Fang Chang +9 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2022 At sites of vascular damage, factor VIII (fVIII) is proteolytically activated by thrombin and binds to activated platelet surfaces with activated factor IX (fIXa) to form the intrinsic “tenase” complex. Previous structural and mutational studies of fVIII
Shaun C. Peters +9 more
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μ-calpain binds to lipid bilayers via the exposed hydrophobic surface of its Ca2+-activated conformation [PDF]
, 2006 μ- and m-calpain are cysteine proteases requiring micro- and millimolar Ca2+ concentrations for their activation in vitro. Among other mechanisms, interaction of calpains with membrane phospholipids has been proposed to facilitate their activation by ...
Machleidt, Werner +5 more
core +1 more source
Superdiffusive motion of membrane-targeting C2 domains [PDF]
Scientific Reports, 2015 AbstractMembrane-targeting domains play crucial roles in the recruitment of signalling molecules to the plasma membrane. For most peripheral proteins, the protein-to-membrane interaction is transient. After proteins dissociate from the membrane they have been observed to rebind following brief excursions in the bulk solution.
Grace Campagnola +4 more
openaire +3 more sources
Calculating the Potential of C2 Domains for Membrane Binding [PDF]
Developmental Cell, 2002 A recent report in Molecular Cell demonstrates the ability of electrostatic calculations to predict the membrane binding properties of structurally characterized C2 domains and assign probable membrane targeting functions to numerous uncharacterized C2 domains.
Merithew, Eric Lee, Lambright, David G.
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Membranes, 2022 Membrane proteins are broadly classified as transmembrane (TM) or peripheral, with functions that pertain to only a single bilayer at a given time. Here, we explicate a class of proteins that contain both transmembrane and peripheral domains, which we ...
Michael Overduin +4 more
doaj +1 more source
The PIP2 binding mode of the C2 domains of rabphilin‐3A [PDF]
Protein Science, 2008 AbstractPhosphatidylinositol‐4,5‐bisphosphate (PIP2) is a key player in the neurotransmitter release process. Rabphilin‐3A is a neuronal C2 domain tandem containing protein that is involved in this process. Both its C2 domains (C2A and C2B) are able to bind PIP2.
Montaville, P. +5 more
openaire +3 more sources
Neoplasia: An International Journal for Oncology Research, 2013 Organotypic models may provide mechanistic insight into colorectal cancer (CRC) morphology. Three-dimensional (3D) colorectal gland formation is regulated by phosphatase and tensin homologue deleted on chromosome 10 (PTEN) coupling of cell division cycle
Ishaan C. Jagan +8 more
doaj +1 more source