Results 101 to 110 of about 157,920 (289)

Machine Learning Accelerated Computational Design of Bio‐Inspired Catalysts in the Nitrogen Reduction Reaction

Advanced Materials, EarlyView.
We introduce a computational workflow that combines quantum chemical calculations and machine learning techniques to predict the catalytic performance of a wide range of catalysts in the nitrogen reduction reaction (NRR). The analysis of the trained models provides insights into the complex structure–activity relationship in experimental catalytic ...
Leonardo Di Ciano, Zihan You, Haoran Chen, Qifan Zhong, Rong‐Zhen Liao, Shaoqi Zhan   +5 more
wiley   +1 more source

From biophysical interaction to structural modeling: bi-terminal G and TGS domains drive rice OsYchF1-OsGAP1 complex formation

Botanical Studies
OsYchF1 belongs to the YchF subfamily in the Obg family of G proteins, and comprises a core G domain, an α-helical domain, and a TGS domain from the N-terminus to the C-terminus.
Suchang Huang, Ziting Wu, Kuang Wang, Yunchuan Liao, Jiaqiang Zeng, Rui Miao   +5 more
doaj   +1 more source

Rescue of HIV-1 release by targeting widely divergent NEDD4-type ubiquitin ligases and isolated catalytic HECT domains to Gag.

PLoS Pathogens, 2010
Retroviruses engage the ESCRT pathway through late assembly (L) domains in Gag to promote virus release. HIV-1 uses a PTAP motif as its primary L domain, which interacts with the ESCRT-I component Tsg101. In contrast, certain other retroviruses primarily
Eric R Weiss, Elena Popova, Hikaru Yamanaka, Hyung Cheol Kim, Jon M Huibregtse, Heinrich Göttlinger   +5 more
doaj   +1 more source

Membrane Binding Kinetics of Protein Kinase C βII Mediated by the C2 Domain^†

, 2016
Conventional isoforms of protein kinase C (PKC) are activated when their two membrane-targeting modules, the C1 and C2 domains, bind the second messengers diacylglycerol (DG) and Ca2+, respectively.
Alexandra C. Newton (1273470), Eric A. Nalefski (2519011)   +1 more
core   +1 more source

C2 domain-iSH2 domain contacts inhibit p85/p110α and are disrupted in oncogenic p85 mutants [PDF]

, 2015
We previously proposed a model of Class IA PI3K regulation in which p85 inhibition of p110α requires (i) an inhibitory contact between the p85 nSH2 domain and the p110α helical domain, and (ii) a contact between the p85 nSH2 and iSH2 domains that orients
El-Sibai, Mirvat, Flinn, Rory J., Girvin, Mark E., Wu, Haiyan, Sen, K. Ilker, Seshagiri, Somasekar, Gerfen, Gary J., Shekar, S. Chandra, Janakiraman, Vasantharajan, Backer, Jonathan M., Jaiswal, Bijay S.   +10 more
core   +1 more source

Ultra‐High‐Throughput Discovery of Multifunctional Polyphenolic Coatings on Droplet Microarrays

Advanced Materials, EarlyView.
An ultra‐high‐throughput (UHT) combinatorial strategy enables the miniaturized synthesis and screening of ≈30 000 polyamine‐polyphenolic (PaPp) coatings using droplet microarrays (DMA). This approach reveals hundreds of previously unknown fluorescent, redox‐active, and antibacterial materials, including multifunctional, cell‐compatible surfaces ...
Vania Tanda Widyaya, Joaquín E. Urrutia Gómez, Paul Reuß, Alexander Welle, Rolf A. Gattung, Jana Mayer, Peter Krolla, Markus Reischl, Pascal Friederich, Anna A. Popova, Thomas Schwartz, Pavel A. Levkin   +11 more
wiley   +1 more source

Co1/Ru Single‐Atom Alloy Catalyst for Sustainable Polypropylene Hydrogenolysis to Long‐Chain Liquid Products

Advanced Materials, EarlyView.
A titania‐supported Co1/Ru single‐atom alloy catalyst enables efficient polypropylene hydrogenolysis. Ru─Co─Ru motifs maintain Ru activity while suppressing excessive chain scission to gaseous products. Both virgin and waste plastics achieve high, environmentally and economically optimal C11+ liquid yields, supporting sustainable chemical recycling ...
Yuzhen Ge, Yimeng Jin, Alexandra Krestnikova, Sibei Zou, Antonio J. Martín, Gonzalo Guillén‐Gosálbez, Javier Pérez‐Ramírez   +6 more
wiley   +1 more source

The Nedd4L ubiquitin ligase is activated by FCHO2-generated membrane curvature

The EMBO Journal
The C2-WW-HECT domain ubiquitin ligase Nedd4L regulates membrane sorting during endocytosis through the ubiquitination of cargo molecules such as the epithelial sodium channel (ENaC). Nedd4L is catalytically autoinhibited by an intramolecular interaction
Yasuhisa Sakamoto, Akiyoshi Uezu, Koji Kikuchi, Jangmi Kang, Eiko Fujii, Toshiro Moroishi, Shiro Suetsugu, Hiroyuki Nakanishi   +7 more
doaj   +1 more source

Analysis of the complete genome of hepatitis B virus subgenotype C2 isolate NHB17965 from a patient with uncomplicated chronicity [version 2; referees: 2 approved, 1 approved with reservations]

F1000Research, 2018
The burden of chronic hepatitis B virus (HBV) infections is increasingly detected nowadays. Herein, we report a complete genome of HBV subgenotype C2 (HBV/C2) from a patient with chronic HBV infection.
Modhusudon Shaha, Palash Kumar Sarker, Md. Saddam Hossain, Keshob Chandra Das, Munira Jahan, Shuvra Kanti Dey, Shahina Tabassum, Abu Hashem, Md. Salimullah   +8 more
doaj   +1 more source

Discontinuous epitopes on the C2 domain of coagulation Factor VIII mapped by computer-designed synthetic peptides

, 2011
International audienceSummary The occurrence of alloantibodies against Factor VIII (FVIII) is the main iatrogenic complication in haemophilia A (HA).
Cayzac, Christopher, Schved, Jean‐françois, Violaine Moreau, Christopher Cayzac, Lapalud, Priscilla, Jean-François Schved, Lebreton, Aurélien, Nguyen, Christophe, Lavigne, Géraldine, Aurélien Lebreton, Priscilla Lapalud, André, Sébastien, Claude Granier, Géraldine Lavigne, Granier, Claude, Sébastien André, Christophe Nguyen, Moreau, Violaine   +17 more
core   +1 more source