Results 101 to 110 of about 2,154,580 (280)

Engineering Pluripotent Stem Cells‐Derived Inner Ear Organoids With Enhanced Maturation and Reproducibility by Micro‐Topographical Cues

Advanced Materials, EarlyView.
Micro‐topographical cues applied through temporally controlled microscale confinement improve the reproducibility, spatial organization, and neurosensory‐associated features of pluripotent stem cell‐derived inner ear organoids. Integration with a vascularized organoid platform further enables controlled investigation of vascular‐epithelial interactions
Harshita Sharma, Jungeun Lim, Woochan Kim, Yeon Ju Kim, Dream Kim, Shinyull Lee, Chaeyeon Park, Stephen Rhee, Shruthy Kuttapan, Jungho Ha, Sang Wook Park, Kyunghoon Kim, Noo Li Jeon, Sunho Park, Yun‐Hoon Choung, Jangho Kim   +15 more
wiley   +1 more source

Rescue of HIV-1 release by targeting widely divergent NEDD4-type ubiquitin ligases and isolated catalytic HECT domains to Gag.

PLoS Pathogens, 2010
Retroviruses engage the ESCRT pathway through late assembly (L) domains in Gag to promote virus release. HIV-1 uses a PTAP motif as its primary L domain, which interacts with the ESCRT-I component Tsg101. In contrast, certain other retroviruses primarily
Eric R Weiss, Elena Popova, Hikaru Yamanaka, Hyung Cheol Kim, Jon M Huibregtse, Heinrich Göttlinger   +5 more
doaj   +1 more source

Autoinhibition of the HECT-Type Ubiquitin Ligase Smurf2 through Its C2 Domain [PDF]

, 2007
SummaryUbiquitination of proteins is an abundant modification that controls numerous cellular processes. Many Ubiquitin (Ub) protein ligases (E3s) target both their substrates and themselves for degradation.
Ogunjimi, Abiodun A., Sicheri, Frank, Wrana, Jeffrey L., Wiesner, Silke, Forman-Kay, Julie D., Wang, Hong-Rui, Rotin, Daniela   +6 more
core   +1 more source

Defect‐Engineered Microwave‐Responsive Ni@C Composites From Waste PET for Catalytic Plastic Upcycling

Advanced Materials, EarlyView.
A circular upcycling strategy transforms waste poly(ethylene terephthalate) bottles into microwave‐responsive Ni@C catalyst featuring lattice‐distorted nickel cores and defective carbon shells. These strain‐rich heterointerfaces enhance dielectric loss and promote localized microwave hotspots, accelerating peroxymonosulfate activation and polymer‐chain
Xiao Lu, Shiying Ren, Jingkai Lin, Kunsheng Hu, Yalan Mo, Shaobin Wang, Wenjie Tian, Xiaoguang Duan   +7 more
wiley   +1 more source

Deterministic Field‐Free Switching of Perpendicular Magnetization by Bulk Mirror Symmetry Broken Bi1−xSbx (012) with High Spin Hall Conductivity

Advanced Materials, EarlyView.
Crystal orientation and domain engineering enable bulk mirror symmetry breaking in Bi1−xSbx, resulting in ultralow current‐induced switching of perpendicular magnetization without an external field. By exploiting single‐domain Bi1−xSbx (012), the authors demonstrate an out‐of‐plane spin Hall conductivity of ∼1.12×105ℏ2eΩ−1m−1$ \sim \!1.12 \ensuremath ...
Seungwon Rho, Youngmin Lee, Jaeseok Huh, Jaehan Park, Hyeong‐Jun Son, Dowoo Pyeon, Mann‐Ho Cho   +6 more
wiley   +1 more source

The Nedd4L ubiquitin ligase is activated by FCHO2-generated membrane curvature

The EMBO Journal
The C2-WW-HECT domain ubiquitin ligase Nedd4L regulates membrane sorting during endocytosis through the ubiquitination of cargo molecules such as the epithelial sodium channel (ENaC). Nedd4L is catalytically autoinhibited by an intramolecular interaction
Yasuhisa Sakamoto, Akiyoshi Uezu, Koji Kikuchi, Jangmi Kang, Eiko Fujii, Toshiro Moroishi, Shiro Suetsugu, Hiroyuki Nakanishi   +7 more
doaj   +1 more source

Analysis of the complete genome of hepatitis B virus subgenotype C2 isolate NHB17965 from a patient with uncomplicated chronicity [version 2; referees: 2 approved, 1 approved with reservations]

F1000Research, 2018
The burden of chronic hepatitis B virus (HBV) infections is increasingly detected nowadays. Herein, we report a complete genome of HBV subgenotype C2 (HBV/C2) from a patient with chronic HBV infection.
Modhusudon Shaha, Palash Kumar Sarker, Md. Saddam Hossain, Keshob Chandra Das, Munira Jahan, Shuvra Kanti Dey, Shahina Tabassum, Abu Hashem, Md. Salimullah   +8 more
doaj   +1 more source

Moiré‐Induced Symmetry Breaking of Charge Order in van der Waals Heterostructures

Advanced Materials, EarlyView.
A uniaxial moiré potential in misfit (MS)1+δTaS2 heterostructures selectively reshape charge order: the embedded 1H‐TaS2 layer hosts an incommensurate charge‐density wave, fragmented into nanometer domains and stripped of threefold symmetry. Superconductivity, however, remains uniform and fully gapped, revealing heterosymmetry stacking as a selective ...
Sandra Sajan, Laura Pätzold, Tarushi Agarwal, Clara Pfister, Haojie Guo, Sisheng Duan, P. V. Sruthibhai, Mariana Rossi, Maria N. Gastiasoro, Sara Barja, Ravi P. Singh, Tim Wehling, Miguel M. Ugeda   +12 more
wiley   +1 more source

Protein Kinase C-Delta C2 Domain Interactions in Breast Cancer

The role of protein kinase C-δ (PKC-δ) in breast cancer has been a major focus for a while. PKC-δ expression correlates negatively with the prognosis of breast cancer, and high PKC-δ expression was associated with reduced relapse-free survival in ...
Khader, Rasha
core   +3 more sources

Bifunctional Catalysis Drives Efficient and Ethanol‐Producing Aqueous Zn‐CO2 Batteries

Advanced Materials, EarlyView.
A unified bifunctional catalyst breaks the trade‐off between CO2 reduction and O2 evolution, delivering high efficiency, ethanol production, and long‐term stability in Zn‐CO2 batteries while revealing degradation pathways for next‐generation bifunctional electrocatalysts.
Divyani Gupta, Jinshuo Zou, Anoja Kawsihan, Jodie A. Yuwono, Zhaoliang Wu, Jun Yu, Yameng Fan, Sailin Liu, Jianfeng Mao, Zaiping Guo   +9 more
wiley   +1 more source