Results 121 to 130 of about 157,920 (289)

ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells

Advanced Science, EarlyView.
With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao, Shannon Erhardt, Li Tang, Xiaotong Chen, Stephen M Farmer, Zixiu Cheng, Wen Chen, Ella Ziyuan Lu, Kihan Sung, Chang‐Ru Tsai, Mingjie Zheng, Sheng Zhang, Yang Liu, Jianxin Wang, Min Li, James F Martin, Jun Wang   +16 more
wiley   +1 more source

Design logic in practice [Elektronisk resurs] : a method to extract design criteria for future C2 systems

, 2018
The world we live in is a complex system tinged with constant change. In order to cope with this fact, a defense mission system needs to adapt to these challenges. The command and control (C2) system is the component of the defense mission system that is
Andersson, Isabell,, Spak, Ulrik,
core  

Transcription Factor Promiscuity Drives Regulatory Rewiring and Evolvability in Gene Networks in Bacteria

Advanced Science, EarlyView.
When a master transcription factor (TF) is lost, bacteria can rapidly rewire gene regulatory networks by co‐opting related regulators. Using experimental evolution in Pseudomonas fluorescens, we show that TF promiscuity (low‐level, non‐cognate binding) provides the raw material for rewiring. Successful co‐option follows a predictable hierarchy governed
Tiffany B. Taylor, Alan M. Rice
wiley   +1 more source

Novel anti-PTEN C2 domain monoclonal antibodies to analyse the expression and function of PTEN isoform variants. [PDF]

PLoS One, 2023
Torices L, Nunes-Xavier CE, López JI, Pulido R.   +3 more
europepmc   +1 more source

C2 Domain Protein Min1 Promotes Eyespot Organization In Chlamydomonas Reinhardtii

, 2008
Assembly and asymmetric localization of the photosensory eyespot in the biflagellate, unicellular green alga Chlamydomonas reinhardtii requires coordinated organization of photoreceptors in the plasma membrane and pigment granule/thylakoid membrane ...
Lamb, Mary Rose, Levitan, Alexander, Dieckmann, Carol L., Berthold, Peter, Rice, Michael E., Danon, Avihai, Mittelmeier, Telsa M.   +6 more
core  

Liquid Metal Nanotransformers for Drug‐Resistant Pan‐Cancer Therapy in Patient‐Derived Organoids

Advanced Science, EarlyView.
Pan‐cancer therapies are severely limited in drug‐resistance patients due to genetic mutations and other factors, resulting in poor therapeutic outcomes and constrained clinical benefit. Liquid metal nanotransformers, a new class of shape‐transformable nanomaterials capable of dramatic morphological changes, offer a promising physical strategy to ...
Xiaojie Yuan, Xuelin Wang, Zhongyao Chen, Shuo Wang, Weining Gao, Ziyi Chen, Runyang Li, Cheng Hao, Lei Zhang, Qiongqiong Zhang, Ke Zhang, Mei Yu, Qian Liu, Jingxuan Wang, Huiping Li, Simpkins Fiona, Jing Liu, Qiang Liu, Peng Liu, Yawei Hu   +19 more
wiley   +1 more source

Characterization and phylogenetic analysis of multiple C2 domain and transmembrane region proteins in maize. [PDF]

BMC Plant Biol, 2022
Zhao Y, Qin Q, Chen L, Long Y, Song N, Jiang H, Si W.   +6 more
europepmc   +1 more source

C2-domains, Structure and Function of a Universal Ca2+-binding Domain [PDF]

Journal of Biological Chemistry, 1998
J, Rizo, T C, Südhof
openaire   +2 more sources

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Down-Regulation of Double C2 Domain Alpha Promotes the Formation of Hyperplastic Nerve Fibers in Aganglionic Segments of Hirschsprung's Disease. [PDF]

Int J Mol Sci, 2022
Xiao J, Meng X, Chen K, Wang J, Wu L, Chen Y, Yu X, Feng J, Li Z.   +8 more
europepmc   +1 more source