Results 141 to 150 of about 2,154,580 (280)

Correction: Structural basis of phosphatidylcholine recognition by the C2-Domain of cytosolic phospholipase A<sub>2</sub>α. [PDF]

open access: yesElife, 2021
Hirano Y   +8 more
europepmc   +1 more source

Compensatory Mitophagy via NEDD4/HIF‐1α/BNIP3 Pathway Restrains EndMT and Renal Allograft Interstitial Fibrosis Induced by TNFα

open access: yesAdvanced Science, EarlyView.
The role of TNFα in the process of renal allograft interstitial fibrosis is complex and multifaceted. As it can promote renal allograft interstitial fibrosis by inducing mitochondrial dysfunction and EndMT, and also mediating compensatory mitophagy through the NEDD4–HIF‐1α–BNIP3 pathway, which clears damaged mitochondria and inhibits EndMT, thereby ...
Dengyuan Feng   +15 more
wiley   +1 more source

The C2 domain of calpain 5 contributes to enzyme activation and membrane localization. [PDF]

open access: yesBiochim Biophys Acta Mol Cell Res, 2021
Bondada V   +6 more
europepmc   +1 more source

Factor VIII C2 domain-specific inhibitory antibody epitopes and membrane binding models.

open access: yes, 2015
(A) Ribbon diagram representation of the fVIII C2 domain bound to different classes of C2-specific inhibitory antibodies. Each X-ray crystal structure was superimposed with the C2 domain structure and residues involved in the different epitopes are shown
Steven M. Mullen (702761)   +8 more
core   +1 more source

Transcription Factor Promiscuity Drives Regulatory Rewiring and Evolvability in Gene Networks in Bacteria

open access: yesAdvanced Science, EarlyView.
When a master transcription factor (TF) is lost, bacteria can rapidly rewire gene regulatory networks by co‐opting related regulators. Using experimental evolution in Pseudomonas fluorescens, we show that TF promiscuity (low‐level, non‐cognate binding) provides the raw material for rewiring. Successful co‐option follows a predictable hierarchy governed
Tiffany B. Taylor, Alan M. Rice
wiley   +1 more source

Gene synthesis, cloning, expression, purification and biophysical characterization of the C2 domain of human tensin [PDF]

open access: yes, 2007
Tensin is a large docking protein found in the adhesive junctions of animal cells and recruited early in the development of cell-substrate contacts. There it binds to the cytoplasmic domain of integrin β1 and caps the barbed ends of filamentous actin ...
Gajula, Kiran Sukumar
core  

Atomic Tuning of Metal‐Support Interactions for Pathway‐Selective CO2 Photoreduction on TiO2

open access: yesAdvanced Science, EarlyView.
Single‐atom Fe and Cu catalysts anchored on TiO2 steer photocatalytic CO2 reduction toward distinct pathways. Fe sites favor rapid *CO desorption and selective CO formation, whereas Cu sites stabilize *CHO intermediates, enabling deep reduction and C─C coupling. Combined spectroscopy and DFT calculations reveal how metal–support interactions and oxygen
Dongyun Kim   +13 more
wiley   +1 more source

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