Results 141 to 150 of about 157,920 (289)
Advanced Science, EarlyView.A nanoparticle‐cluster‐on‐mirror (NPcoM) serves as a functionally deterministic sub‐nanocavity that emulates picocavities, enabling extreme light–matter interactions and polaritonic phenomena. ABSTRACT Pushing nanoscale optical confinement to its ultimate limits defines the regime of nano‐cavity quantum electrodynamics (nano‐cQED), where light‐matter ...
Huatian Hu +10 more
wiley +1 more source
CellsChronic stress, a risk factor for many neuropsychiatric conditions, causes dysregulation in the immune system in both humans and animal models. Additionally, inflammation and synapse loss have been associated with deficits in social behavior.
Amit Kumar Madeshiya +4 more
doaj +1 more source
Correction: Structural basis of phosphatidylcholine recognition by the C2-Domain of cytosolic phospholipase A<sub>2</sub>α. [PDF]
Elife, 2021 Hirano Y +8 more
europepmc +1 more source
Protein Kinase C-Delta C2 Domain Interactions in Breast Cancer
The role of protein kinase C-δ (PKC-δ) in breast cancer has been a major focus for a while. PKC-δ expression correlates negatively with the prognosis of breast cancer, and high PKC-δ expression was associated with reduced relapse-free survival in ...
Khader, Rasha
core
Cloning and characterisation of phospholipase C X-domain containing proteins (PLCXDs)
, 2015 Members of the phosphoinositide-specific phospholipase C (PI-PLC) enzyme family play a fundamental role in cell signalling pathways by regulating cytosolic calcium and/or the activity of several protein kinases. This thesis reports the identification,
Gellatly, Steven Alexander
core
, 2016 The protein kinase Cα (PKCα) enzyme is a member of a broad family of serine/threonine kinases, which are involved in varied cellular signaling pathways. The initial step of PKCα activation involves the C2 subunit docking with the cell membrane, which is ...
Jeff Wereszczynski (1273932) +1 more
core +1 more source
Advanced Science, EarlyView.ARC3 levels are controlled by cytosolic and chloroplast proteolytic systems. PUB52 mediates ARC3 precursor ubiquitination and degradation in the cytosol, while CLPC1 promotes ARC3 degradation in chloroplasts, where ARC2 protects ARC3 from excessive breakdown. Disrupting these components causes chloroplast division defects, placing them upstream of ARC3.
Yang Yuan +5 more
wiley +1 more source
A role for the C2 domain of the ubiquitin-protein ligase Nedd4
, 2000 grantor: University of TorontoN_eural precursor cell-e_xpressed d_evelopmentally d_ownregulated 4 (Nedd4) is a ubiquitin-protein ligase that has an N-terminal c_onserved region 2_ of PKC (C2) domain, three or four WW domains and a C-terminal ...
Plant, Pamela J.
core +1 more source
The C2 domain of calpain 5 contributes to enzyme activation and membrane localization. [PDF]
Biochim Biophys Acta Mol Cell Res, 2021 Bondada V +6 more
europepmc +1 more source
Advanced Science, EarlyView.This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon +21 more
wiley +1 more source