Results 71 to 80 of about 4,044,136 (204)

Brillouin optical time-domain analyzer with a fiber ring laser working on the SLM regime [PDF]

, 2017
In this paper we present the employment of an Erbium Fiber Ring Laser structure working on the Single Longitudinal Mode regime within a Brillouin optical time domain analyzer.
López Higuera, José Miguel, Mirapeix Serrano, Jesús María, Rodríguez Cobo, Luis, Ruiz Lombera, Rubén   +3 more
core   +1 more source

Calculating the Potential of C2 Domains for Membrane Binding [PDF]

Developmental Cell, 2002
A recent report in Molecular Cell demonstrates the ability of electrostatic calculations to predict the membrane binding properties of structurally characterized C2 domains and assign probable membrane targeting functions to numerous uncharacterized C2 domains.
Merithew, Eric Lee, Lambright, David G.
openaire   +3 more sources

The Dual Roles of MAGE-C2 in p53 Ubiquitination and Cell Proliferation Through E3 Ligases MDM2 and TRIM28

Frontiers in Cell and Developmental Biology, 2022
The tumor suppressor p53 is critical for the maintenance of genome stability and protection against tumor malignant transformation, and its homeostasis is usually regulated by ubiquitination.
Yunshan Liu, Beibei Cao, Liqiao Hu, Jingjing Ye, Wei Tian, Xiaojing He   +5 more
doaj   +1 more source

Genetic Analysis of Synaptotagmin C2 Domain Specificity in Regulating Spontaneous and Evoked Neurotransmitter Release

Journal of Neuroscience, 2013
Synaptic vesicle fusion mediates communication between neurons and is triggered by rapid influx of Ca2+. The Ca2+-triggering step for fusion is regulated by the synaptic vesicle transmembrane protein Synaptotagmin 1 (Syt1).
Jihye Lee, Z. Guan, Y. Akbergenova, J. Littleton   +3 more
semanticscholar   +1 more source

Modelling the Full-Length Inactive PKC-δ Structure to Explore Regulatory Accessibility and Selective Targeting Opportunities

Pharmaceuticals
Background/Objectives: Protein kinase C-δ (PKC-δ) is a pivotal regulator of cellular signalling, and its dysregulation contributes to oncogenesis. While certain isolated PKC-δ domains have been crystallised, the full-length architecture and interdomain ...
Rasha Khader, Lodewijk V. Dekker
doaj   +1 more source

Electrostatic and Hydrophobic Interactions Differentially Tune Membrane Binding Kinetics of the C2 Domain of Protein Kinase Cα*

Journal of Biological Chemistry, 2013
Background: The C2 domain is a Ca2+ sensor that drives the first step in the activation of conventional PKC isozymes. Results: Hydrophobic interactions drive membrane association and electrostatic interactions drive membrane retention of the C2 domain ...
A. Scott, Corina E. Antal, A. Newton
semanticscholar   +1 more source

The ergonomics of command and control [PDF]

, 2006
Since its inception, just after the Second World War, ergonomics research has paid special attention to the issues surrounding human control of systems.
Chris Baber, Neville A. Stanton, Sheridan T., Smalley J., Stanton N. A.   +4 more
core   +1 more source

PRIP (Phospholipase C-related but Catalytically Inactive Protein) Inhibits Exocytosis by Direct Interactions with Syntaxin 1 and SNAP-25 through Its C2 Domain*

Journal of Biological Chemistry, 2013
Background: PRIP inhibits exocytosis, but the underlying mechanism is unknown. Results: PRIP interacts with syntaxin-1 and SNAP-25 through its C2 domain and inhibits SNARE complex formation.
Zhao Zhang, H. Takeuchi, Jing Gao, Daguang Wang, D. James, T. Martin, M. Hirata   +6 more
semanticscholar   +1 more source

Structure of the C2 domain from novel protein kinase Cϵ. A membrane binding model for Ca2+-independent C2 domains

Journal of Molecular Biology, 2001
Protein kinase Cepsilon (PKCepsilon) is a member of the novel PKCs which are activated by acidic phospholipids, diacylglycerol and phorbol esters, but lack the calcium dependence of classical PKC isotypes. The crystal structures of the C2 domain of PKCepsilon, crystallized both in the absence and in the presence of the two acidic phospholipids, 1,2 ...
Ochoa, Wendy F., García-García, Josefa, Fita, Ignacio, Corbalán-García, Senena, Verdaguer, Núria, Gómez-Fernández, Juan C.   +5 more
openaire   +3 more sources

Redefining the architecture of ferlin proteins: Insights into multi-domain protein structure and function.

PLoS ONE, 2022
Ferlins are complex, multi-domain proteins, involved in membrane trafficking, membrane repair, and exocytosis. The large size of ferlin proteins and the lack of consensus regarding domain boundaries have slowed progress in understanding molecular-level ...
Matthew J Dominguez, Jon J McCord, R Bryan Sutton   +2 more
doaj   +1 more source