Results 151 to 160 of about 38,034 (262)

The mitochondrial‐targeted antioxidant SkQ1 prevents skeletal muscle mitochondrial‐apoptotic but not necroptotic signalling during ovarian cancer

The Journal of Physiology, EarlyView.
Abstract figure legend An evaluation of the degree to which mitochondrial hydrogen peroxide emission (mH2O2)‐mediated apoptotic and necroptotic signalling contributes to skeletal muscle atrophy in an orthotopic epithelial ovarian cancer (EOC) model. To determine whether attenuating mH2O2 could prevent regulated cell death signalling and mitigate muscle
Shahrzad Khajehzadehshoushtar, Luca J. Delfinis, Fasih A. Rahman, Madison C. Garibotti, Shivam Gandhi, Aditya N. Brahmbhatt, Brooke A. Morris, Bianca Garlisi, Sylvia Lauks, Caroline Aitken, Leslie Ogilvie, Zhu‐Xu Zhang, Jeremy A. Simpson, Joe Quadrilatero, Jim Petrik, Christopher G. R. Perry   +15 more
wiley   +1 more source

Gene Expression During C2C12 Differentiation

Vanderbilt Undergraduate Research Journal
Congenital heart disease (CHD) is one of the most common types of birth defect and is very poorly understood. To comprehend this disease better, the normal genetic expression associated with myocyte differentiation must be mapped out. This gives a deeper understanding of how cardiomyocytes (cardiac muscle cells) divide and specialize, which can ...
Zoe Storaasli, Yan Zhao, Marlin Touma
openaire   +1 more source

Hypoxia and hypercapnia elicit overlapping but distinct skeletal muscle toxicities

The Journal of Physiology, EarlyView.
Abstract figure legend Hypoxia and hypercapnia cause overlapping skeletal muscle phenotypes, including atrophy, change in myofibre metabolic profile and myogenic response to injury. Both signals operate via distinct cellular pathways. Abstract Skeletal muscle dysfunction is strongly associated with elevated mortality in acute and chronic pulmonary ...
Joseph Balnis, Ariel Jaitovich
wiley   +1 more source

PGC-1α regulates cell adhesion genes in C2C12 myotubes.

, 2016
(A) RT-PCR analysis of several cell adhesion genes down-regulated dependent on PGC-1α in C2C12 cells. Cells were infected with either an empty vector control adenovirus (“V”) or a PGC-1α encoding adenovirus (“P”). Readings were normalized to β-Actin mRNA.
Neri Minsky (3589763), Robert G. Roeder (156660)   +1 more
core   +1 more source

Stac2 genetic deletion alters mouse chromaffin cells’ CaV channel composition, increases membrane excitability and reduces vesicle exocytosis

The Journal of Physiology, EarlyView.
Abstract figure legend Stac2 adaptor protein is expressed in neurons and endocrine cells. Using a global Stac2 knockout mouse model here we investigated the role of endogenous Stac2 in adrenal gland mouse chromaffin cell (MCC) excitability and catecholamine vesicle exocytosis.
Stefanie M. Geisler, Noelia Jacobo‐Piqueras, Tamara Theiner, Ryoichi S. Taguchi, Laura E. Häfele, Marta Campiglio, Petronel Tuluc   +6 more
wiley   +1 more source

Indole family and neomycin sulfate: Inductors of differentiation in C2C12 and RD cell lines

Rhabdomyosarcoma (RMS) is a highly aggressive tumor primarily affecting the pediatric population, that generally originates from a failure in the embryonic differentiation of myogenic precursor cells. Standard treatment involves surgery, chemotherapy and
Pronsato, Lucía, Blanco, Nicolás Olegario, Milanesi, Lorena Magdalena, Frattini, Natalia María, Vasconsuelo, Andrea Anahi   +4 more
core   +1 more source

Voltage‐gated potassium channels mediate thyroid hormone control of skeletal muscle excitability

The Journal of Physiology, EarlyView.
Abstract figure legend Thyroid hormone (TH)‐dependent remodelling of potassium (K+) channel networks regulates skeletal muscle (SkM) excitability. Triiodothyronine (T3), locally generated from thyroxine (T4) by type 2 deiodinase (D2), binds thyroid hormone receptors (TRα/β) and modulates transcription via thyroid response elements (TREs).
Annarita Nappi, Caterina Miro, Annunziata Gaetana Cicatiello, Ilaria Piccialli, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Rosa Sirica, Melania Murolo, Emery Di Cicco, Daniela Terracciano, Anna Pannaccione, Monica Dentice   +12 more
wiley   +1 more source

Phf2 expression and PHF2 localization in C2C12 myotubes.

(A) Phf2 mRNA expression during differentiation in C2C12 myotubes (n = 4 wells per condition in one experiment). (B) Immunofluorescence staining of PHF2 (green) and DAPI (blue) in C2C12 myotubes on days 0 and 7 post differentiation. Scale bar, 100 μm.
Taku Fukushima (18501267), Takeshi Nikawa (306818), Taiju Fujioka (18501273), Sachi Kuse (18501270), Yuka Hasegawa (686118), Satoru Masubuchi (2149456), Iori Sakakibara (418765)   +6 more
core   +1 more source

Cyclin G2 inhibits C2C12 cells osteogenic differentiation through antagonizing Wnt/β-catenin Signaling.

, 2014
(A) Western Blot analysis of β-catenin, cyclin D1 and cyclin G2 expression in OS-medium induced C2C12 cells. (B) Western Blot analysis of β-catenin expression in nuclear fraction in C2C12 cells induced by OS-medium. (C) Western Blot analysis of β-catenin,
Xing Liu (221084), Shusen Wang (433515), Qi Liu (33068), Shengqiang Qu (530054), Yang Luo (350920), Jinlan Gao (530053), Chunyan Ji (443711)   +6 more
core   +1 more source

Comparative analysis of microRNAs in bovine colostrum and neonatal calf blood

Journal of the Science of Food and Agriculture, Volume 106, Issue 10, Page 5799-5809, 15 August 2026.
Abstract BACKGROUND MicroRNAs (miRNAs) are short non‐coding RNAs that participate in a wide range of biological processes. MiRNAs are present in high concentrations in colostrum, and these may be potentially transferred to newborn calves being fed colostrum.
Do T Hue, Kiro Petrovski, Yan Ren, John L Williams, Tong Chen, Wai Y Low, Thien D Van, Cynthia D K Bottema   +7 more
wiley   +1 more source