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C3 glomerulopathy: a new classification
Nature Reviews Nephrology, 2010Several distinct pathological patterns of glomerular inflammation are associated with abnormal regulation of the complement system, specifically, with dysregulation of the alternative pathway of the complement system. However, these conditions share the pathological finding of complement C3 (C3) deposited within the glomerulus in the absence of ...
Fadi, Fakhouri +4 more
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C3 Glomerulopathy: Pathogenesis and Treatment
Advances in Chronic Kidney Disease, 2020C3 glomerulopathy (C3G) is a rare set of kidney diseases with 2 patterns: C3 glomerulonephritis (C3GN) and dense deposit disease. Pathogenesis of both diseases is due to complement dysregulation in the alternative pathway. Acquired or genetic alterations of the regulatory proteins of the complement pathway result in C3G.
Syeda Behjat, Ahmad, Andrew S, Bomback
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Advances in Kidney Disease and Health
C3 glomerulopathy (C3G) is a rare disorder marked by deposition of C3 in the glomerulus, resulting in damage to the glomerular filtration unit and presenting with features of the nephritic and nephrotic syndromes. Fundamentally, C3G is caused by dysregulation of the alternative pathway of the complement cascade, either due to genetic variants or ...
Benjamin, Wooden +2 more
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C3 glomerulopathy (C3G) is a rare disorder marked by deposition of C3 in the glomerulus, resulting in damage to the glomerular filtration unit and presenting with features of the nephritic and nephrotic syndromes. Fundamentally, C3G is caused by dysregulation of the alternative pathway of the complement cascade, either due to genetic variants or ...
Benjamin, Wooden +2 more
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Membranoproliferative Glomerulonephritis und C3‑Glomerulopathie
Der Internist, 2019Based on an increasingly better pathophysiological understanding over the last 10 years, in 2010 a new classification of glomerulonephritis with dominant or codominant C3 deposits was introduced and the predominant subgoup was termed C3 glomerulopathy (C3G). In the current classification, immune complex mediated membranoproliferative glomerulonephritis
B, Hohenstein, K, Amann, J, Menne
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Diagnosis and treatment of C3 glomerulopathy
Clinical Nephrology, 2013The purpose of this review is to summarize our current understanding of the principal characteristics of C3 glomerulopathy as a framework for patient evaluation with the goal of setting the stage for a mechanistic approach to treatment. We also review published treatment experience and comment on future initiatives to devise treatment protocols for ...
Carla M, Nester, Richard J, Smith
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Histopathology of MPGN and C3 glomerulopathies
Nature Reviews Nephrology, 2014'Membranoproliferative' describes glomerular injury characterized by capillary wall thickening and mesangial expansion owing to increased matrix deposition and hypercellularity. The presence of immune deposits is indicative of membranoproliferative glomerulonephritis (MPGN).
H Terence, Cook, Matthew C, Pickering
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C3 nephritic factor associated with C3 glomerulopathy in children
Pediatric Nephrology, 2013C3 glomerulopathy (C3G) is characterized by predominant C3 deposits in glomeruli and dysregulation of the alternative pathway of complement. Half of C3G patients have a C3 nephritic factor (C3NeF). C3G incorporated entities with a range of features on microscopy including dense deposit diseases (DDD) and C3 glomerulonephritis (C3GN).
Camille, Nicolas +16 more
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Recurrent C3 glomerulopathy after kidney transplantation
Transplantation ReviewsThe complement system is part of innate immunity and is pivotal in protecting the body against pathogens and maintaining host homeostasis. Activation of the complement system is triggered through multiple pathways, including antibody deposition, a mannan-binding lectin, or activated complement deposition.
Shota, Obata +3 more
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