Results 141 to 150 of about 3,935,620 (190)

The Role of Complement C3a Receptor in Stroke

NeuroMolecular Medicine, 2019
© 2019, Springer Science+Business Media, LLC, part of Springer Nature. The complement system is a key regulator of the innate immune response against diseased tissue that functions across multiple organ systems. Dysregulation of complement contributes to
Saif Ahmad, Kanchan Bhatia, Adam Kindelin, A. Ducruet   +3 more
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Complement C3a Receptor (C3aR) Mediates Vascular Dysfunction, Hippocampal Pathology, and Cognitive Impairment in a Mouse Model of VCID

Translational Stroke Research, 2022
Vascular contributions to cognitive impairment and dementia (VCID) secondary to chronic mild-moderate cerebral ischemia underlie a significant percentage of cases of dementia.
Kanchan Bhatia, Adam Kindelin, M. Nadeem, M. Khan, Jun-Xiang Yin, Alberto Fuentes, Karis Miller, G. Turner, M. Preul, A. Ahmad, E. Mufson, M. Waters, Saif Ahmad, A. Ducruet   +13 more
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Inhibition of the C3a receptor attenuates sepsis-induced acute lung injury by suppressing pyroptosis of the pulmonary vascular endothelial cells.

Free Radical Biology & Medicine, 2022
Acute lung injury (ALI) is the leading cause of bacterial sepsis-related death because of disrupted pulmonary endothelial barrier, resulting in protein-rich pulmonary oedema, an influx of pro-inflammatory cells and refractory hypoxaemia.
Zhanjun Li, Yu-Chang Wang, Quanrui Feng, Yang Zhuang, Zhen-Xing Xie   +4 more
semanticscholar   +1 more source

C3a(desArg) does not bind to and signal through the human C3a receptor

Immunology Letters, 1999
Contradictory results have been published in the past regarding the functional responses of different cell types to the anaphylatoxin C3a and its natural catabolite C3a(desArg). To elucidate the interaction of the C3a receptor (C3aR) with its ligand(s) we studied the binding of human recombinant C3a (rC3a) and rC3a(desArg) to RBL-2H3 transfectants ...
Thomas Werfel, Jörg Zwirner, Otto Götze   +2 more
exaly   +3 more sources

Expression of a Functional Anaphylatoxin C3a Receptor by Astrocytes [PDF]

Journal of Neurochemistry, 1998
Abstract: Human astrocyte cell lines reportedly contain a specific receptor for the complement anaphylatoxin C3a based on ligand‐binding studies, functional responses, and RNA analysis by RT‐PCR. Uptake of 125I‐C3a by astrocytes was specific and reversible. Scatchard analysis indicated the presence of two classes of binding sites. High‐affinity binding
Philippe Gasque, Marc Fontaine, C Patte
exaly   +3 more sources

Evidence that the receptor for C4a is distinct from the C3a receptor

Immunopharmacology, 1997
The cDNAs encoding the human (hC3aR) and mouse C3a receptors (mC3aR) were functionally expressed in RBL-2H3 cells. A calcium mobilization assay was utilized to assess the biologic activity of human anaphylatoxins, and C3a synthetic peptide agonists on hC3aR and mC3aR cells and this activity was compared to the activity of the anaphylatoxins on human ...
Tony E Hugli, Robert S Ames, Henry M Sarau   +2 more
exaly   +3 more sources

The Complement C3a–C3a Receptor Axis Regulates Epithelial-to-Mesenchymal Transition by Activating the ERK Pathway in Pancreatic Ductal Adenocarcinoma

Anticancer Research, 2022
Background: We aimed to clarify the role of complement C3a and its receptor C3aR in progression of pancreatic ductal adenocarcinoma (PDAC). Materials and Methods: We evaluated the serum levels of C3 and C3a in patients with PDAC.
R. Suzuki, Y. Okubo, T. Takagi, M. Sugimoto, Yuki Sato, Hiroki Irie, Jun Nakamura, Mika Takasumi, T. Kato, M. Hashimoto, Ryouichiro Kobashi, T. Hikichi, H. Ohira   +12 more
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Ligands for C3a and C5a Receptors [PDF]

, 2023
Prolonged activation of the complement system of blood proteins in response to infection or tissue injury can lead to inflammatory diseases. This thesis investigates the potency, selectivity and structures of reported and rationally designed new ligands for human complement receptors C3aR and C5aR, towards development of new therapeutic agents. Chapter
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Europium-Labeled Synthetic C3a Protein as a Novel Fluorescent Probe for Human Complement C3a Receptor. [PDF]

Bioconjugate Chemistry, 2017
Measuring ligand affinity for a G protein-coupled receptor is often a crucial step in drug discovery. It has been traditionally determined by binding putative new ligands in competition with native ligand labeled with a radioisotope of finite lifetime.
Aline Dantas de Araujo, Chongyang Wu, Kai‐Chen Wu, R. Reid, T. Durek, Junxian Lim, D. Fairlie   +6 more
semanticscholar   +6 more sources