Results 161 to 170 of about 3,935,620 (190)
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A role for the C3a anaphylatoxin receptor in the effector phase of asthma
Nature, 2000Asthma is a chronic inflammatory disease of the airways and lung mucosa with a strong correlation to atopy and acquired (IgE) immunity. However, many features of bronchial asthma, such as smooth muscle contraction, mucus secretion and recruitment of inflammatory cells, are consistent with the actions of complement anaphylatoxins, in particular C3a and ...
A A, Humbles +7 more
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Receptor for the C3a anaphylatoxin is expressed by neurons and glial cells
Glia, 1999Little is known about the expression of the receptor for complement anaphylatoxin C3a (C3aR) in the central nervous system (CNS). In this study, we provide the first evidence that neurons are the predominant cell type expressing C3aR in the normal CNS.
N, Davoust +4 more
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Selective Hexapeptide Agonists and Antagonists for Human Complement C3a Receptor
Journal of Medicinal Chemistry, 2010Human anaphylatoxin C3a, formed through cleavage of complement protein C3, is a potent effector of innate immunity via activation of its G protein coupled receptor, human C3aR. Previously reported short peptide ligands for this receptor either have low potency or lack receptor selectivity.
Scully, Conor C. G. +6 more
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The C3a receptor antagonist SB 290157 has agonist activity
Immunology Letters, 2005The anaphylatoxin C3a is an important immune regulator with a number of distinct functions in both innate and adaptive immunity. Many of these roles have been ascribed to C3a based on studies in mice genetically modified to lack its precursor, C3, or its receptor, C3aR.
Marie-Claude, Mathieu +10 more
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High Levels of Complement C3a Receptor in the Glomeruli in Lupus Nephritis
American Journal of Kidney Diseases, 2007Taking into consideration the key role of the complement system in renal diseases, we investigated molecular and cellular properties of the human complement C3a receptor (C3aR) in vitro and in situ, looking at its expression in several human renal pathological states.Several antibodies were generated and used for immunohistochemistry and Western blot ...
Masashi, Mizuno +4 more
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Expression of Receptors for Anaphylatoxins C3a and C5a on Rat Islet Preparations
Transplantation Proceedings, 2011Complement activation has been implicated in the development of the instant blood-mediated inflammatory reaction (IBMIR). In particular, anaphylatoxins C3a and C5a elicit a broad range of proinflammatory effects, including chemotaxis of inflammatory cells and cytokine release.
K, Tokodai +5 more
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Cellular receptors to the anaphylatoxins C3a and C5a.
Biochemical Society symposium, 1987A single component in the plasma membrane of human polymorphonuclear leukocytes (hPMN) has been identified as the binding site for C5a. Labelled human C5a can be cross-linked to a 48,000-Mr membrane component on the hPMN surface by using the bifunctional reagent ethylene glycol bis(succinimidyl succinate).
R, Huey +3 more
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