Results 151 to 160 of about 3,935,620 (190)
C3a Receptor Antagonist Attenuates Brain Injury after Intracerebral Hemorrhage
Journal of Cerebral Blood Flow and Metabolism, 2009 Neuroprotective therapy targeting the complement cascade may reduce injury associated with intracerebral hemorrhage (ICH). We investigated the role of C3a-receptor antagonist (C3aRA) after ICH in mice.
Brad E Zacharia, Andrew F Ducruet
exaly +2 more sources
G protein coupled receptor specificity for C3a and compound 48/80-induced degranulation in human mast cells: Roles of Mas-related genes MrgX1 and MrgX2 [PDF]
European Journal of Pharmacology, 2011 Although human mast cells express G protein coupled receptors for the anaphylatoxin C3a, previous studies indicated that C3a causes mast cell degranulation, at least in part, via a C3a receptor-independent mechanism similar to that proposed for ...
Hydar Ali +2 more
exaly +2 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Pharmacological activity of C3a and C3a receptor ligands
2023The complement system is an integral component of the innate immune response to infection and injury. The anaphylatoxins, C3a and C5a, are produced upon activation of the classical, alternative or mannan-binding lectin complement pathways. C5a is a potent pro-inflammatory mediator and overactivation or underegulation of C5a is implicated in the ...
openaire +2 more sources
Modulation of C3a Activity: Internalization of the Human C3a Receptor and its Inhibition by C5a
The Journal of Immunology, 1999Abstract The C3a receptor (C3aR) is expressed on most human peripheral blood leukocytes with the exception of resting lymphocytes, implying a much higher pathophysiological relevance of the anaphylatoxin C3a as a proinflammatory mediator than previously thought.
B, Settmacher +7 more
openaire +2 more sources
Neuroscience Letters, 2020
BACKGROUND Hyperactivation of complement C3 and inflammation-related activation of NLR family pyrin domain containing 3 (NLRP3) inflammasome are implicated in the etiology of stress-related disorders.
Jing Li +10 more
semanticscholar +1 more source
BACKGROUND Hyperactivation of complement C3 and inflammation-related activation of NLR family pyrin domain containing 3 (NLRP3) inflammasome are implicated in the etiology of stress-related disorders.
Jing Li +10 more
semanticscholar +1 more source
In Xenopus oocytes the human C3a and C5a receptors elicit a promiscuous response to the anaphylatoxins [PDF]
FEBS Letters, 1996 The Xenopus laevis oocyte has been widely utilized for cloning and functional expression of G-protein coupled receptors (GPCR). This system was used for the functional expression and characterization of the recently identified human C3a receptor ...
Robert S Ames, R S Ames
exaly +2 more sources
Biochemical and Biophysical Research Communications, 1998
The anaphylatoxin C3a, generated during complement activation, is a factor known to mediate various inflammatory reactions. The human C3a receptor (C3aR) was recently cloned and identified to be a member of the G-protein-coupled receptor family. C3aR is characterized by seven transmembrane domains including a large second extracellular loop that ...
Y, Fukuoka, J A, Ember, T E, Hugli
openaire +2 more sources
The anaphylatoxin C3a, generated during complement activation, is a factor known to mediate various inflammatory reactions. The human C3a receptor (C3aR) was recently cloned and identified to be a member of the G-protein-coupled receptor family. C3aR is characterized by seven transmembrane domains including a large second extracellular loop that ...
Y, Fukuoka, J A, Ember, T E, Hugli
openaire +2 more sources
Biochemistry, 1992
The anaphylatoxic peptide C3a is part of a basic immunological defense mechanism, the complement system. Research on the human C3a receptor and signal transduction is hampered by the lack of a suitable human cell or cell line. We screened tumor cell lines and human blood cells for a C3a-dependent increase in cytosolic Ca2+ ([Ca2+]i) and analyzed this ...
A, Klos +6 more
openaire +2 more sources
The anaphylatoxic peptide C3a is part of a basic immunological defense mechanism, the complement system. Research on the human C3a receptor and signal transduction is hampered by the lack of a suitable human cell or cell line. We screened tumor cell lines and human blood cells for a C3a-dependent increase in cytosolic Ca2+ ([Ca2+]i) and analyzed this ...
A, Klos +6 more
openaire +2 more sources
European Journal of Pharmacology, 2019
Neurofibrillary tangles aggregated from hyperphosphorylated tau protein are the main pathological feature of Alzheimer's disease (AD). Complement C3 (or C3a) is the core component of the complement system and is associated with AD pathological processes.
Jun-Jie Hu +7 more
semanticscholar +1 more source
Neurofibrillary tangles aggregated from hyperphosphorylated tau protein are the main pathological feature of Alzheimer's disease (AD). Complement C3 (or C3a) is the core component of the complement system and is associated with AD pathological processes.
Jun-Jie Hu +7 more
semanticscholar +1 more source
Molecular Immunology, 2018
HighlightsComplement C3aR is expressed on the apical ventricular zone in the developing mouse brain.Pharmacological stimulation of C3aR reduces the proliferation of neural progenitor cells.C3aR‐/‐ mice have impaired recall memory in cognitive testing ...
L. Coulthard +4 more
semanticscholar +1 more source
HighlightsComplement C3aR is expressed on the apical ventricular zone in the developing mouse brain.Pharmacological stimulation of C3aR reduces the proliferation of neural progenitor cells.C3aR‐/‐ mice have impaired recall memory in cognitive testing ...
L. Coulthard +4 more
semanticscholar +1 more source