Results 91 to 100 of about 37,904 (214)
Isocitrate Dehydrogenase Mutations in Cancer: From Bench to Bedside Applications
MedComm, Volume 7, Issue 5, May 2026.Mutant isocitrate dehydrogenase affects multiple cancer types. Alterations in IDH1 and IDH2 result in abnormal enzyme activity, leading to the overproduction of D‐2‐hydroxyglutarate (D‐2HG). This metabolite disrupts cellular metabolism and epigenetic regulation, driving cancer initiation, progression, and metastasis.
Yuhan Fang +6 more
wiley +1 more source
Adherence-Promoting Design Features in Pediatric Neurostimulators for ADHD Patients
BioengineeringThe emergence of remote health monitoring and increased at-home care emphasizes the importance of patient adherence outside the clinical setting. This is particularly pertinent in the treatment of Attention Deficit Hyperactivity Disorder (ADHD) in ...
William Delatte +3 more
doaj +1 more source
Frontiers in Immunology, 2019 Properdin (FP) is a positive regulator of the immune system stimulating the activity of the proteolytically active C3 convertase C3bBb in the alternative pathway of the complement system. Here we present two crystal structures of FP and two structures of
Dennis V. Pedersen +14 more
doaj +1 more source
Journal of Geophysical Research: Solid Earth, Volume 131, Issue 5, May 2026.Abstract Melt migration in partially molten rocks is commonly described by porous flow models controlled by the hydro‐mechanical compaction length, which effectively explains melt extraction at mid‐ocean ridges. However, this framework cannot account for the paradoxical accumulation of small melt fractions into rhythmic leucosome–melanosome bands in ...
Qingpei Sun +3 more
wiley +1 more source
Human α2‐Macroglobulin: Architecture, Mechanisms, and Functional Implications
The FASEB Journal, Volume 40, Issue 8, 30 April 2026.Visual representation of human α2‐macroglobulin in its native and induced conformations. General functions associated with the native form (green), the induced form (white), and both conformations (light red) are indicated. ABSTRACT α2‐Macroglobulin (α2M) is a large glycoprotein and one of the most abundant proteins found in the plasma of vertebrates ...
Pietro de Carvalho Andrade +2 more
wiley +1 more source
PLoS Pathogens, 2008 The Gram-positive bacterium Staphylococcus aureus, similar to other pathogens, binds human complement regulators Factor H and Factor H related protein 1 (FHR-1) from human serum.
Katrin Haupt +7 more
doaj +1 more source
PLoS ONE, 2020 Plasmodium falciparum malaria killed 451,000 people in 2017. Merozoites, the stage of the parasite that invades RBCs, are a logical target for vaccine development.
José A Stoute +2 more
doaj +1 more source
The Murine Factor H-Related Protein FHR-B Promotes Complement Activation
Frontiers in Immunology, 2017 Factor H-related (FHR) proteins consist of varying number of complement control protein domains that display various degrees of sequence identity to respective domains of the alternative pathway complement inhibitor factor H (FH). While such FHR proteins
Marcell Cserhalmi +6 more
doaj +1 more source
Effect of complement-protein-C3b density on the binding of complement factor H to surface-bound C3b [PDF]
Biochemical Journal, 1991 Various amounts of the activation fragment C3b of the complement (C) protein C3 were coupled to Sepharose 4B by catalysis with the C3 convertase of the alternative pathway of C. The binding of radioactively labelled C proteins B and H (= factor H) to the C3b-carrying particles was assayed. It was found that the relative binding of H, but not of B, fell
openaire +2 more sources
A Khintchine type theorem for hyperplanes
, 2005 We prove that the convergence Khintchine theorem holds for affine hyperplanes whose parametrizing matrices satisfy a mild Diophantine condition.
Ghosh, Anish
core +1 more source