Results 81 to 90 of about 37,904 (214)

Analysis of the Putative Role of CR1 in Alzheimer's Disease: Genetic Association, Expression and Function. [PDF]

PLoS ONE, 2016
Chronic activation of the complement system and induced inflammation are associated with neuropathology in Alzheimer's disease (AD). Recent large genome wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) in the C3b/C4b
Maria I Fonseca, Shuhui Chu, Aimee L Pierce, William D Brubaker, Richard E Hauhart, Diego Mastroeni, Elizabeth V Clarke, Joseph Rogers, John P Atkinson, Andrea J Tenner   +9 more
doaj   +1 more source

The role of salivary and intestinal complement system inhibitors in the midgut protection of triatomines and mosquitoes. [PDF]

PLoS ONE, 2009
Saliva of haematophagous arthropods contain biomolecules involved directly or indirectly with the haematophagy process, and among them are encountered some complement system inhibitors.
Veruska Cavalcanti Barros, Jéssica Góes Assumpção, André Miranda Cadete, Vânia Cristina Santos, Reginaldo Roris Cavalcante, Ricardo Nascimento Araújo, Marcos Horácio Pereira, Nelder Figueiredo Gontijo   +7 more
doaj   +1 more source

Bounds on ternary cyclotomic coefficients

, 2008
We present a new bound on $A = \max_n |a_{pqr}(n)|$, where $a_{pqr}(n)$ are the coefficients of a ternary cyclotomic polynomial.
Bzdega, Bartlomiej
core   +2 more sources

Randomised, phase 1 evaluation of the safety, tolerability, pharmacokinetics and pharmacodynamics of iptacopan in healthy volunteers

British Journal of Pharmacology, Volume 183, Issue 11, Page 2874-2889, June 2026.
Abstract Background and Purpose Overactivation of the alternative pathway (AP) underlies several diseases. Iptacopan is an oral, first‐in‐class, highly potent specific inhibitor of factor B, a key AP protease. Experimental Approach The analysis included data from two phase 1 randomised, volunteer‐blinded, placebo‐controlled studies: Study 1, a single ...
Irina Baltcheva, Guido Junge, Kenneth Kulmatycki, Robert Schmouder, Anna Schubart, Marie‐Anne Valentin   +5 more
wiley   +1 more source

Breakdown of integrability in a quasi-one-dimensional ultracold bosonic gas

, 2008
We demonstrate that virtual excitations of higher radial modes in an atomic Bose gas in a tightly confining waveguide result in effective three-body collisions that violate integrability in this quasi-one-dimensional quantum system and give rise to ...
I. E. Mazets, J. Schmiedmayer, S. Hofferberth, T. Schumm   +3 more
core   +1 more source

Activation of the Lectin Pathway Drives Persistent Complement Dysregulation in Long COVID

Immunology, Volume 178, Issue 2, Page 261-268, June 2026.
The complement cascade, a series of blood proteins that assists in the recognition and neutralisation of pathogens, either independently or in conjunction with antibodies, is persistently activated in patients with long COVID. We found that blood plasma samples from patients with long COVID contained elevated concentrations of the mannan‐binding lectin‐
Samuel B. K. Keat, Priyanka Khatri, Youssif M. Ali, Chanuka H. Arachchilage, Gregory Demopulos, Kirsten Baillie, Kelly L. Miners, Kristin Ladell, Samantha A. Jones, Helen E. Davies, David A. Price, Wioleta M. Zelek, B. Paul Morgan, Wilhelm J. Schwaeble, Nicholas J. Lynch   +14 more
wiley   +1 more source

Selective Transfer Hydrogenation of Polyenes to Monoenes Catalysed by Shvo's Catalyst

Advanced Synthesis &Catalysis, Volume 368, Issue 9, 5 May 2026.
We report the reduction of polyenes to monoenes with near‐perfect selectivities at full conversion with isopropanol as hydrogen source. The reaction is catalysed by Shvo's catalyst and the selectivity towards conjugation, semihydrogenation or full hydrogenation can be adjusted via the reaction temperature.
Justus Diekamp, Annika Schmidt, Florian Lehmann, Lea Küsel, Carsten Strohmann, Dieter Vogt, Thomas Seidensticker   +6 more
wiley   +1 more source

Sirt3 Genetically Engineered Apoptotic Bodies Alleviate Skeletal Aging by Limiting Aggravated NLRP3 Inflammasome Activation of Senescent Macrophages

Advanced Science, Volume 13, Issue 26, 8 May 2026.
The senescence of macrophages leads to a decrease in the expression of Sirtuin3 (Sirt3), which in turn aggravates the NLRP3 inflammasome activation and IL‐1β secretion, thereby promoting the aging‐related osteoporosis. Sirt3‐enriched apoptotic bodies (ABs‐Sirt3) generated through genetic editing approaches can alleviate skeletal aging by targeting ...
Yanglin Wu, Shifeng Ling, Jiayi Mao, Hongyi Wang, Bo Wang, Zhenjia Che, Wenguo Cui, Ming Cai   +7 more
wiley   +1 more source

Borrelia burgdorferi sensu lato Employs Several Escape Mechanisms to Bypass the Human Defense System

European Journal of Immunology, Volume 56, Issue 5, May 2026.
Integrated overview of host defense and immune evasion in Lyme Borreliosis. Bbsl evades immunity through tick saliva‐mediated suppression of innate defenses, TLR2/NOD2‐driven cytokine dysregulation, and interference with JAK/STAT and CIITA‐dependent antigen presentation.
Zara Karami, Hadewych J. M. ter Hofstede, Leo A. B. Joosten   +2 more
wiley   +1 more source

C3b Receptor in Normal Human Skin

Journal of Investigative Dermatology, 1981
Receptors for C3b in normal skin were studied. C3b was produced by treating normal human serum with cobra venom factor and by partial digestion of purified C3 with trypsin. Cryostat sections of normal human skin were incubated with C3b, followed by a direct immunofluorescent technique using monospecific goat antihuman C3. The histologic localization of
Thyresson, Hakan N., McDuffie, Frederic C., Schroeter, Arnold L.   +2 more
openaire   +2 more sources