Results 101 to 110 of about 6,779 (207)

Distinct Pharmacodynamic Complement Biomarker Signatures Define Iptacopan and Pegcetacoplan Treatment in C3 Glomerulopathy

Kidney International Reports
Introduction: C3 glomerulopathy (C3G) is driven by alternative pathway (AP) dysregulation. Iptacopan inhibits factor B, whereas pegcetacoplan inhibits C3/C3b, suggesting distinct pharmacodynamic (PD) biomarker profiles.
Yuzhou Zhang, Héctor Martín Merinero, Anna R. Carmen, Kameron Kruger, Renee X. Goodfellow, Dingwu Shao, Sarah M. Roberts, Angela F.M. Nelson, Nicole C. Meyer Horning, Sydney S. Jellison, Didier Mandelbrot, Neetika Garg, Carla M. Nester, Richard J.H. Smith   +13 more
doaj   +1 more source

[Clinicopathological study of Henoch-Schönlein purpura nephritis with special reference to C3c deposits].

Nihon Jinzo Gakkai shi, 1996
The aim of this study was to evaluate glomerular C3c deposits of Henoch-Schönlein purpura nephritis (HSPN) in children. Fifty-one patients aged 7-15 years (20 males and 31 females) were studied. On histological investigation, crescent formation seen under light microscopy and subepithelial electron dense deposits (EDD) under electron microscopy were ...
KUMADA, Kazuo, SUZUKI, Junzo, KUME, Kazunari, SUZUKI, Shigeo, YOSHIDA, Kazuo, ISOME, Masato, KATO, Kazuo, SUZUKI, Hitoshi, YUGETA, Eichi   +8 more
openaire   +2 more sources

Additional file 3: Figure S3. of Complement activation at the motor end-plates in amyotrophic lateral sclerosis

, 2016
Representative confocal immunofluorescence for synaptophysin (SYN-Cy3) detecting the motor nerve terminal (A, B) or S100b (Cy3) detecting the terminal Schwann cells (C, D) double stained with anti-C3c recognizing C3c part of C3 and C3b (FITC) in control (
Frank Baas (23060), Nawal Bahia El Idrissi (3466046), Sanne Bosch (3466049), Dirk Troost (86798), Valeria Ramaglia (3466052), Eleonora Aronica (135729)   +5 more
core   +1 more source

C3 activation in human NASH.

, 2014
A) Semi-quantitative analysis of Western blot (see 2B) for hepatic protein C3c levels in subjects with NASH and subjects with healthy livers (p = 0.24).
Sander S. Rensen (292951), Ann Driessen (359519), Froukje J. Verdam (642109), Ronit Shiri-Sverdlov (186636), Bas Boonen (642111), Nicole D. Bouvy (355641), Charlotte de Jonge (642110), Filip M. Segers (642108), Jan Willem M. Greve (642112), Wim A. Buurman (162734)   +9 more
core   +1 more source

Hypertension in Living Kidney Donors Has No Effect on Complement Activation and Fibrosis

Kidney & Blood Pressure Research
Introduction: In the past, elevated blood pressure was considered an exclusion criterion for living kidney donation because of concerns about premature kidney failure. Hypertension leads to complement deposits and renal fibrosis in the kidney.
Nadine Wagner, Miriam Angeloni, Fulvia Ferrazzi, Janina Müller-Deile, Maike Büttner-Herold, Kerstin Amann, Christoph Daniel, Eva Vonbrunn   +7 more
doaj   +1 more source

Predicting the affinity of compstatin peptide with non-natural amino acids to human C3c protein by scoring molecular dynamics simulations

, 2022
ABSTRAC: Peptides are chemical entities composed of natural and non-natural amino acids that have been used successfully as drugs, vaccines, biomarkers, among others. However, these can be easily cleaved and degraded by proteases, where their breaking of
Muñoz Gomez, Kelly Yohana
core  

Utility of Direct Immunofluorescence Using Proteinase-k for Antigen Retrieval in Formalin-Fixed, Paraffin Embedded Kidney Biopsy Sections

Turkish Journal of Nephrology
Background: Immunofluorescence on frozen sections (IF-F) is crucial for diagnosing immune complex-related glomerular diseases. Immunofluorescence on para"in block (IF-P) is applicable when IF-F is unfeasible.
Hemalatha Akurathi, Sobiya Mahnaz Ayesha, Sofia Dondapati, Megha S Uppin, Sree Bhushan Raju, Swarnalatha Guditi, Gangadhar Taduri, Padmini Chaprala   +7 more
doaj   +1 more source

Utilización de reibergramas para evaluar la síntesis intratecal de C3c y C4 en niños con meningoencefalitis por Neisseria meningitidis

, 2019
La meningoencefalitis por Neisseria meningitidis afectó sensiblemente a la población infantil cubana antes de la exitosa campaña con la vacuna producida en Cuba contra esta bacteria.
Padilla Docal, Bárbara, Coifiu Fanego, Raisa B., Dorta Contreras, Alberto J.   +2 more
core  

Complement factors in newly diagnosed Nigerian schizoprenic patients and those on antipsychotic therapy [PDF]

, 2013
The role of Complement factors in the pathogenesis of psychiatric disorders is enormous, but the data on levels and functions of complement factors in patients with schizophrenia are scanty and conflicting.
Akinlade, K.S, Idonije, O.B, Arinola, OG, Ihenyen, O   +3 more
core   +1 more source

Complement levels and their diagnostic utility in neonatal sepsis

BMC Pediatrics
Background This study evaluated the diagnostic value of complement levels in neonatal sepsis and their roles in disease progression. Methods This diagnostic accuracy study, conducted in Guangdong Province, China (January 2021-February 2022), involved 41 ...
Fuqiang Diao, Feng Zhong, Lingling Tang, Chunming Gu, Junfei Guo, Lihong Wu, Weixiang Wu, Mingyong Luo   +7 more
doaj   +1 more source