Low Serum Levels of Complement C3c at Diagnosis Indicate Poor Outcome in Antineutrophil Cytoplasmic Antibody-Associated Glomerulonephritis [PDF]
Kidney International Reports, 2022 Désirée Tampe +3 more
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Complement C3c as a Biomarker in Heart Failure [PDF]
Mediators of Inflammation, 2013 Introduction. Experimental data indicates an important role of the innate immune system in cardiac remodeling and heart failure (HF). Complement is a central effector pathway of the innate immune system. Animals lacking parts of the complement system are
A. Frey +5 more
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Multi-omics analyses demonstrate complement dysregulation is involved in focal segmental glomerulosclerosis [PDF]
Frontiers in ImmunologyIntroductionThe complement system is increasingly recognized as a contributor to the pathogenesis of focal segmental glomerulosclerosis (FSGS). However, a comprehensive, tissue-based characterization of complement dysregulation in human FSGS kidneys ...
Yingxue Xu +4 more
doaj +2 more sources
Selective Complement Inhibition in Anti-p200 Pemphigoid: Immune Infiltrate Profiles and Therapeutic Implications Compared to Bullous Pemphigoid [PDF]
BiomoleculesAnti-p200 pemphigoid is an autoimmune blistering disease (AIBD) caused by autoantibodies against laminin β4 and/or γ1, and clinically resembles bullous pemphigoid (BP) as well as the inflammatory variant of epidermolysis bullosa acquisita (EBA).
Shirin Emtenani +5 more
doaj +2 more sources
Expression of melanoma differentiation-associated gene 5 in the epidermis and cutaneous deposition of complement C3 and immunoglobulins in patients with dermatomyositis. [PDF]
PLoS ONEObjectivesDermatomyositis (DM) is an autoimmune disease characterized by interface dermatitis, but the immunopathological features underlying cutaneous inflammation remain incompletely understood.
Yoshiaki Zaizen +6 more
doaj +2 more sources
Heliox versus trimix in closed‐circuit rebreather diving: A comparative study of pulmonary and decompression stress in male divers [PDF]
Physiol RepAbstract Closed‐circuit rebreather (CCR) and helium‐based breathing mixtures are widely used in technical diving. This study compared the effects of Heliox and Trimix on pulmonary function and decompression stress during CCR dives. Nineteen divers performed a standardized dive (50 ± 3 msw, 147 ± 10 min) using Heliox (16% O2/84% He; n = 9) or Trimix (16%
Gouin E +9 more
europepmc +2 more sources
Complement and autoantibody levels under anifrolumab therapy in SLE: implications for clinical practice [PDF]
Frontiers in ImmunologyIntroductionAnifrolumab (ANI), a type I interferon receptor antagonist, has demonstrated clinical efficacy in systemic lupus erythematosus (SLE). However, its effects on serological markers commonly used to assess disease activity in clinical practice ...
Jan-Gerd Rademacher +3 more
doaj +2 more sources
Urinary complement C3 fragment levels and their clinical relevance in MPO-ANCA-associated vasculitis [PDF]
Scientific ReportsAnti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is an autoimmune disease characterized by systemic small-vessel inflammation. Complement activation, particularly through the alternative pathway, has been implicated in AAV pathogenesis ...
Yanglin Hu +8 more
doaj +2 more sources
Complement in Renal Disease as a Potential Contributor to Arterial Hypertension
Kidney & Blood Pressure Research, 2021 Objective: Complement deposition is prevalent in kidney biopsies of patients with arterial hypertension and hypertensive nephropathy, but an association of hypertension and complement deposition or involvement of complement in the pathogenesis of ...
Lisa-Maren Fischer +6 more
doaj +1 more source
Frontiers in Immunology, 2022 Hidradenitis suppurativa (HS) is a chronic auto-inflammatory skin disease with a complex and multifactorial pathogenesis involving both the innate and adaptive immune system.
K. R. van Straalen +8 more
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