Results 1 to 10 of about 790,520 (218)

Low Serum Levels of Complement C3c at Diagnosis Indicate Poor Outcome in Antineutrophil Cytoplasmic Antibody-Associated Glomerulonephritis [PDF]

Kidney International Reports, 2022
To the Editor: We read with great interest the recent study by Lionaki et al. regarding the value of low serumcomplementC3levelsasanindependentpredictorof poor renal prognosis in patientswith pauci-immune antineutrophil cytoplasmic antibody (ANCA ...
Désirée Tampe, Eva Baier, Samy Hakroush, Björn Tampe   +3 more
doaj   +9 more sources

Complement C3c as a Biomarker in Heart Failure [PDF]

Mediators of Inflammation, 2013
Introduction. Experimental data indicates an important role of the innate immune system in cardiac remodeling and heart failure (HF). Complement is a central effector pathway of the innate immune system. Animals lacking parts of the complement system are
A. Frey, G. Ertl, C. E. Angermann, U. Hofmann, S. Störk, S. Frantz   +5 more
doaj   +6 more sources

Redefined complement C3c structures have significant increase in the plasma of ovarian cancer patients [PDF]

J Chin Med Assoc
Background: Ovarian cancer (OC) is the third most common gynecological cancer. Effective biomarkers are required for OC as in the case of other cancers.
Dongwei Chen, Yi-Wen Chang, Chin-Hsiang Chien, P. Torng, Y. Tsay   +4 more
semanticscholar   +4 more sources

Increased expression of complement C3c, iC3b, and cells containing CD11b or CD14 in experimentally induced psoriatic lesion [PDF]

Clin Exp Immunol
Psoriasis is a chronic inflammatory skin disease with a characteristic isomorphic reaction, i.e. the Köbner reaction, induced by slight epidermal trauma. In this study, the tape-stripping technique was used to induce the development of Köbner reaction in
Dina Rahkola, R. Harvima, I. Harvima
semanticscholar   +4 more sources

Selective Complement Inhibition in Anti-p200 Pemphigoid: Immune Infiltrate Profiles and Therapeutic Implications Compared to Bullous Pemphigoid [PDF]

Biomolecules
Anti-p200 pemphigoid is an autoimmune blistering disease (AIBD) caused by autoantibodies against laminin β4 and/or γ1, and clinically resembles bullous pemphigoid (BP) as well as the inflammatory variant of epidermolysis bullosa acquisita (EBA).
Shirin Emtenani, Tina Rastegar Lari, Charlotte Kiehne, Nina van Beek, Maike M. Holtsche, Enno Schmidt   +5 more
doaj   +3 more sources

Claudin-2 enhances human antibody-mediated complement-dependent cytotoxicity of porcine endothelial cells by modulating antibody binding and complement activation [PDF]

Frontiers in Immunology
BackgroundImmune rejection represents a significant barrier to transplantation, especially in the context of xenotransplantation. Endothelial cells (ECs) derived from pigs serve as the initial barrier against the human immune system in ...
Weilong Li, Fang Yang, Dexin Yang, Zhuoheng Song, Zigan Xu, Jinmei Wu, Yanmei Li, Zixi Chen, Peishan Chen, Yeye Yu, Ting Xie, Cuishan Yang, Liying Zhou, Shaodong Luan, Hanchao Gao   +14 more
doaj   +3 more sources

Complement levels and their diagnostic utility in neonatal sepsis [PDF]

BMC Pediatrics
Background This study evaluated the diagnostic value of complement levels in neonatal sepsis and their roles in disease progression. Methods This diagnostic accuracy study, conducted in Guangdong Province, China (January 2021-February 2022), involved 41 ...
Fuqiang Diao, Feng Zhong, Lingling Tang, Chunming Gu, Junfei Guo, Lihong Wu, Weixiang Wu, Mingyong Luo   +7 more
doaj   +3 more sources

Urinary complement C3 fragment levels and their clinical relevance in MPO-ANCA-associated vasculitis [PDF]

Scientific Reports
Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is an autoimmune disease characterized by systemic small-vessel inflammation. Complement activation, particularly through the alternative pathway, has been implicated in AAV pathogenesis ...
Yanglin Hu, Mingjun Shi, Qian Huang, Sheng Wan, Miao Zhang, Zengsi Wang, Wei Huang, Shuang Zhang, Fei Xiong   +8 more
doaj   +3 more sources

Complement split product C3c in saliva as biomarker for periodontitis and response to periodontal treatment [PDF]

Journal of Periodontal Research, 2020
Background and Objective The complement system is engaged in inflammatory reactions both in the periodontal pockets and in the periodontium itself, where it can mediate tissue destruction.
M. A. Grande, D. Belstrøm, C. Damgaard, P. Holmstrup, S. Thangaraj, C. Nielsen, Y. Palarasah   +6 more
semanticscholar   +7 more sources

C3c沉积可预测2型糖尿病患者经活检证实的糖尿病肾病更差的肾脏结局

Journal of Diabetes, 2022
Background Although extensive efforts have been paid to identify reliable predictors for renal outcomes of diabetic kidney disease (DKD) patients in type 2 diabetes mellitus (T2DM), there are still only a limited number of predictive factors for DKD ...
Meng‐Rui Li, Zi‐Jun Sun, Dong‐Yuan Chang, Xiao‐Juan Yu, Su‐Xia Wang, Min Chen, Ming‐Hui Zhao   +6 more
doaj   +2 more sources