Complement C3c as a Biomarker in Heart Failure [PDF]
Mediators of Inflammation, 2013 Introduction. Experimental data indicates an important role of the innate immune system in cardiac remodeling and heart failure (HF). Complement is a central effector pathway of the innate immune system. Animals lacking parts of the complement system are
A. Frey +5 more
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Low Serum Levels of Complement C3c at Diagnosis Indicate Poor Outcome in Antineutrophil Cytoplasmic Antibody-Associated Glomerulonephritis [PDF]
Kidney International Reports, 2022 Björn Tampe +2 more
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Structure of Compstatin in Complex with Complement Component C3c Reveals a New Mechanism of Complement Inhibition [PDF]
Journal of Biological Chemistry, 2007 Undesired complement activation is a major cause of tissue injury in various pathological conditions and contributes to several immune complex diseases. Compstatin, a 13-residue peptide, is an effective inhibitor of the activation of complement component C3 and thus blocks a central and crucial step in the complement cascade.
Bert J C Janssen +2 more
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Complement C3c and C4c as predictors of death in heart failure [PDF]
IJC Metabolic & Endocrine, 2015 AbstractBackgroundActivation of the immune system is one of the several pathways suggested as involved in Heart Failure (HF). The complement system is a key component of innate immunity. We hypothesized that complement proteins C3 and C4 can be an important predictor of death in patients with this condition.Methods380 patients admitted with acute HF ...
Sandra Martins +2 more
exaly +4 more sources
Intrathecal synthesis of complement components C3c and C4 in the central nervous system infections with signs of the acute serous meningitis syndrome [PDF]
Vojnosanitetski Pregled, 2002 Two hundred and ten patients with meningismus and the infections of the central nervous system (CNS) with the clinical symptoms and signs of the acute serous meningitis syndrome, were divided into groups according to etiology (enterovirus meningitis ...
Tatomirović Željka +2 more
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Redefined complement C3c structures have significant increase in the plasma of ovarian cancer patients. [PDF]
J Chin Med AssocBackground: Ovarian cancer (OC) is the third most common gynecological cancer. Effective biomarkers are required for OC as in the case of other cancers. Therefore, here we explored whether plasma proteolytic products could serve as potential biomarkers.
Chen DH +4 more
europepmc +4 more sources
Expression of melanoma differentiation-associated gene 5 in the epidermis and cutaneous deposition of complement C3 and immunoglobulins in patients with dermatomyositis. [PDF]
PLoS ONEObjectivesDermatomyositis (DM) is an autoimmune disease characterized by interface dermatitis, but the immunopathological features underlying cutaneous inflammation remain incompletely understood.
Yoshiaki Zaizen +6 more
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Complement and autoantibody levels under anifrolumab therapy in SLE: implications for clinical practice [PDF]
Frontiers in ImmunologyIntroductionAnifrolumab (ANI), a type I interferon receptor antagonist, has demonstrated clinical efficacy in systemic lupus erythematosus (SLE). However, its effects on serological markers commonly used to assess disease activity in clinical practice ...
Jan-Gerd Rademacher +3 more
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Selective Complement Inhibition in Anti-p200 Pemphigoid: Immune Infiltrate Profiles and Therapeutic Implications Compared to Bullous Pemphigoid [PDF]
BiomoleculesAnti-p200 pemphigoid is an autoimmune blistering disease (AIBD) caused by autoantibodies against laminin β4 and/or γ1, and clinically resembles bullous pemphigoid (BP) as well as the inflammatory variant of epidermolysis bullosa acquisita (EBA).
Shirin Emtenani +5 more
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Increased expression of complement C3c, iC3b, and cells containing CD11b or CD14 in experimentally induced psoriatic lesion. [PDF]
Clin Exp ImmunolAbstract Psoriasis is a chronic inflammatory skin disease with a characteristic isomorphic reaction, i.e. the Köbner reaction, induced by slight epidermal trauma. In this study, the tape-stripping technique was used to induce the development of Köbner reaction in 18 subjects with psoriasis.
Rahkola D, Harvima RJ, Harvima IT.
europepmc +3 more sources