Results 21 to 30 of about 3,342 (187)
Clinical and Experimental Immunology, 1993 SUMMARYWe have investigated the cross-reactivity of various species in ncocpitope-specific methods for quantification of human complement aclivatlon products. In contrast to most other species examined, baboon showed a substantial cross-reactivity supporting a high degree of homology between human and bahoon complement.
T E, Mollnes +9 more
openaire +4 more sources
Urinary complement C3 fragment levels and their clinical relevance in MPO-ANCA-associated vasculitis [PDF]
Scientific ReportsAnti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is an autoimmune disease characterized by systemic small-vessel inflammation. Complement activation, particularly through the alternative pathway, has been implicated in AAV pathogenesis ...
Yanglin Hu +8 more
doaj +2 more sources
Is Early Complement Activation in Renal Transplantation Associated with Later Graft Outcome? [PDF]
Kidney & Blood Pressure Research, 2018 Background/Aims: Complement activation is important in post-transplantation renal injury, but data on its role as predictor of transplant outcome/complications when assessed in donor kidneys are lacking.
Steffen Bobka +7 more
doaj +2 more sources
The Complement System in ANCA-Associated Vasculitis: Mechanistic Insights, Therapeutic Horizons, and Unmet Clinical Needs. [PDF]
Immun Inflamm DisComplement activation, particularly via the alternative pathway, drives inflammation and organ damage in ANCA‐associated vasculitis. This review highlights mechanistic insights, tissue and biomarker evidence, and clinical implications of targeting the C5a–C5aR1 axis.
Sunmboye K, Millan P.
europepmc +2 more sources
Complement levels and their diagnostic utility in neonatal sepsis [PDF]
BMC PediatricsBackground This study evaluated the diagnostic value of complement levels in neonatal sepsis and their roles in disease progression. Methods This diagnostic accuracy study, conducted in Guangdong Province, China (January 2021-February 2022), involved 41 ...
Fuqiang Diao +7 more
doaj +2 more sources
Claudin-2 enhances human antibody-mediated complement-dependent cytotoxicity of porcine endothelial cells by modulating antibody binding and complement activation [PDF]
Frontiers in ImmunologyBackgroundImmune rejection represents a significant barrier to transplantation, especially in the context of xenotransplantation. Endothelial cells (ECs) derived from pigs serve as the initial barrier against the human immune system in ...
Weilong Li +14 more
doaj +2 more sources
Acta Pharmaceutica Sinica B, 2015 Traditionally, determination of inhibitory potency of complement inhibitors is performed by the hemolytic assay. However, this assay is not applicable to the lectin pathway, thus impeding the understanding of complement inhibitors against the overall ...
Mulu Wu +3 more
doaj +2 more sources
JHEP Reports, 2023 Background & Aims: Cirrhosis-associated immune dysfunction (CAID) affects both innate and adaptive immunity. This study investigated the complement system, immunoglobulins, and acute-phase proteins and their prognostic relevance in patients with ...
Benedikt Simbrunner +10 more
doaj +1 more source
C3c沉积可预测2型糖尿病患者经活检证实的糖尿病肾病更差的肾脏结局
Journal of Diabetes, 2022 Background Although extensive efforts have been paid to identify reliable predictors for renal outcomes of diabetic kidney disease (DKD) patients in type 2 diabetes mellitus (T2DM), there are still only a limited number of predictive factors for DKD ...
Meng‐Rui Li +6 more
doaj +1 more source
Surgical and Experimental Pathology, 2023 Background Immunofluorescence studies on frozen sections are an essential component in the evaluation of renal biopsies. The basic panel in most centres constitutes IgG, IgA, IgM, C3c, C1q, Kappa and Lambda light chain antibody testing.
Shilpi Thakur, Balan Louis Gaspar
doaj +1 more source