Results 21 to 30 of about 790,520 (218)

Intrathecal synthesis of complement components C3c and C4 in the central nervous system infections with signs of the acute serous meningitis syndrome [PDF]

Vojnosanitetski Pregled, 2002
Two hundred and ten patients with meningismus and the infections of the central nervous system (CNS) with the clinical symptoms and signs of the acute serous meningitis syndrome, were divided into groups according to etiology (enterovirus meningitis ...
Tatomirović Željka, Bokun Radojka, Bokonjić Dubravko   +2 more
doaj   +3 more sources

Mannose-binding lectin deficiency with eosinophilic meningoencephalitis due to Angiostrongylus cantonensis in children: a case series [PDF]

Journal of Medical Case Reports, 2011
Introduction Eosinophilic meningitis, a potentially fatal disease caused by Angiostrongylus cantonensis, is considered an emerging infectious disease.
de Paula-Almeida Olga, Martínez-Alderete René H, Bu-Coifiu-Fanego Raisa, Dorta-Contreras Alberto J, Padilla-Docal Bárbara, Reiber Hansotto, Jensenius Jens   +6 more
doaj   +3 more sources

Early Activation of the Complement System After Brain Death in Clinical Kidney Donation and Transplantation [PDF]

Transplantation
Background. Brain death (BD) results in an inflammatory response, including complement activation. The clinical impact of prolonged BD duration on the graft-to-be is still unclear.
Laura W D Knijff, Mieke F. van Essen, Sandra W. van der Kooij, D. V. van Gijlswijk-Janssen, J. Mulvey, M. L. Lo Faro, Rutger J. Ploeg, C. van Kooten   +7 more
semanticscholar   +2 more sources

The loss of glycocalyx integrity impairs complement factor H binding and contributes to cyclosporine-induced endothelial cell injury

Frontiers in Medicine, 2023
BackgroundCalcineurin inhibitors (CNIs) are associated with nephrotoxicity, endothelial cell dysfunction, and thrombotic microangiopathy (TMA). Evolving evidence suggests an important role for complement dysregulation in the pathogenesis of CNI-induced ...
Chia Wei Teoh, Chia Wei Teoh, Chia Wei Teoh, Chia Wei Teoh, Magdalena Riedl Khursigara, Magdalena Riedl Khursigara, Magdalena Riedl Khursigara, Carolina G. Ortiz-Sandoval, Jee Woo Park, Jun Li, Arlette Bohorquez-Hernandez, Valentina Bruno, Valentina Bruno, Valentina Bruno, Emily E. Bowen, Spencer A. Freeman, Spencer A. Freeman, Lisa A. Robinson, Lisa A. Robinson, Lisa A. Robinson, Lisa A. Robinson, Christoph Licht, Christoph Licht, Christoph Licht, Christoph Licht, Christoph Licht   +25 more
doaj   +2 more sources

Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b [PDF]

Journal of Molecular Biology, 2010
The human complement system plays an essential role in innate and adaptive immunity by marking and eliminating microbial intruders. Activation of complement on foreign surfaces results in proteolytic cleavage of complement component 3 (C3) into the potent opsonin C3b, which triggers a variety of immune responses and participates in a self-amplification
Brandon L, Garcia, Kasra X, Ramyar, Apostolia, Tzekou, Daniel, Ricklin, William J, McWhorter, John D, Lambris, Brian V, Geisbrecht   +6 more
openaire   +4 more sources

Complement in acute and chronic arthritides: assessment of C3c, C9, and protectin (CD59) in synovial membrane. [PDF]

Annals of the Rheumatic Diseases, 1996
To investigate the role of complement cascade induced damage and protection against it in acute arthritides compared to rheumatoid arthritis and other chronic joint derangements.C3c, C9, and protectin (CD59) were examined by avidin-biotin-peroxidase complex staining.Marked deposits of C3c and C9 were found in synovial vasculature and intercellular ...
Y T, Konttinen, A, Ceponis, S, Meri, A, Vuorikoski, P, Kortekangas, T, Sorsa, A, Sukura, S, Santavirta   +7 more
openaire   +4 more sources

A novel fusion protein reduces kidney complement in experimental C3 glomerulopathy [PDF]

Clin Exp Immunol
Complement activation contributes to kidney damage in many types of glomerulonephritis and complement inhibition therapy is approved for IgA nephropathy and C3 glomerulopathy.
T. Malik, K. Kwiatkowska, H. Lomax-Browne, C. Bottomley, Matthew Bright, Zhang Sung Tean, Ahmet K Akturk, Ian E Alexander, G. Logan, Matthew C Pickering   +9 more
semanticscholar   +2 more sources

IgM Antibodies Targeting Malondialdehyde Promote Complement-Mediated Liver Injury in Alcohol-Related Liver Disease. [PDF]

Liver Int
ABSTRACT Background and Aims Alcohol‐related liver disease (ALD) is associated with elevated blood immunoglobulin‐type M (IgM) levels and hepatic lipid peroxidation. Nevertheless, the functional relevance of systemic IgM targeting lipid peroxidation products during ALD is incompletely understood.
Rajcic D, da Silva BP, Baranovskyi T, Simbrunner B, Hofer BS, Hoebinger C, Duckova T, Papac-Milicevic N, Listabarth S, Weber S, Vyssoki B, König D, Burger K, Bergheim I, Binder CJ, Mandorfer M, Reiberger T, Hendrikx T.   +17 more
europepmc   +2 more sources

The Complement System in ANCA-Associated Vasculitis: Mechanistic Insights, Therapeutic Horizons, and Unmet Clinical Needs. [PDF]

Immun Inflamm Dis
Complement activation, particularly via the alternative pathway, drives inflammation and organ damage in ANCA‐associated vasculitis. This review highlights mechanistic insights, tissue and biomarker evidence, and clinical implications of targeting the C5a–C5aR1 axis.
Sunmboye K, Millan P.
europepmc   +2 more sources

Complement in Renal Disease as a Potential Contributor to Arterial Hypertension

Kidney & Blood Pressure Research, 2021
Objective: Complement deposition is prevalent in kidney biopsies of patients with arterial hypertension and hypertensive nephropathy, but an association of hypertension and complement deposition or involvement of complement in the pathogenesis of ...
Lisa-Maren Fischer, Laura A. Fichte, Maike Büttner-Herold, Fulvia Ferrazzi, Kerstin Amann, Kerstin Benz, Christoph Daniel   +6 more
doaj   +1 more source