Deposition of complement C3c, immunoglobulin (Ig)G4 and IgG at the basement membrane of pancreatic ducts and acini in autoimmune pancreatitis [PDF]
Histopathology, 2010 Detlefsen S, Bräsen J H, Zamboni G, Capelli P & Klöppel G (2010) Histopathology57, 825–835 Deposition of complement C3c, immunoglobulin (Ig)G4 and IgG at the basement membrane of pancreatic ducts and acini in autoimmune pancreatitis Aims: Autoimmune pancreatitis (AIP) is a type of pancreatitis whose immunopathogenesis is still unknown. It has been
Sönke Detlefsen +2 more
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Functional assessment of mouse complement pathway activities and quantification of C3b/C3c/iC3b in an experimental model of mouse renal ischaemia/reperfusion injury [PDF]
Journal of Immunological Methods, 2015 The complement system is an essential component of our innate immunity, both for the protection against infections and for proper handling of dying cells. However, the complement system can also contribute to tissue injury and inflammatory responses.
Juha Kotimaa +2 more
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Complement split product C3c in saliva as biomarker for periodontitis and response to periodontal treatment [PDF]
Journal of Periodontal Research, 2020 AbstractBackground and ObjectiveThe complement system is engaged in inflammatory reactions both in the periodontal pockets and in the periodontium itself, where it can mediate tissue destruction. The aim of this study was, first, to compare salivary levels of the total complement system protein C3 and its split product, fluid‐phase C3c in patients with
Maria Anastasia Grande +6 more
openaire +7 more sources
Haemolytic complement activity and C3c serum concentration in pigs [PDF]
Archives Animal Breeding, 1999 Abstract. Because of the importance of the complement system in disease resistance through direct lysis of target cells and support of other mechanisms of the immune System, individual Variation in haemolytic complement activity and C3 concentration in pigs prior and after vaccination were evaluated.
Wimmer, K. +6 more
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Complement in Renal Disease as a Potential Contributor to Arterial Hypertension
Kidney & Blood Pressure Research, 2021 Objective: Complement deposition is prevalent in kidney biopsies of patients with arterial hypertension and hypertensive nephropathy, but an association of hypertension and complement deposition or involvement of complement in the pathogenesis of ...
Lisa-Maren Fischer +6 more
doaj +3 more sources
Complement alternative pathway activation in human nonalcoholic steatohepatitis. [PDF]
PLoS ONE, 2014 The innate immune system plays a major role in the pathogenesis of nonalcoholic steatohepatitis (NASH). Recently we reported complement activation in human NASH.
Filip M Segers +9 more
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Complement, but Not Platelets, Plays a Pivotal Role in the Outcome of Mucormycosis In Vivo
Journal of Fungi, 2023 Background: Mucormycetes, a heterogeneous group of fungi, induce a life-threatening disease called mucormycosis. Immune deficiencies represent a major risk factor; hence, we wanted to illuminate the role of complement and platelets in the defense against
Verena Harpf +8 more
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Complement activation in Hidradenitis suppurativa: Covert low-grade inflammation or innocent bystander? [PDF]
Frontiers in Immunology, 2022 Hidradenitis suppurativa (HS) is a chronic auto-inflammatory skin disease with a complex and multifactorial pathogenesis involving both the innate and adaptive immune system.
K. R. van Straalen +8 more
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Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b [PDF]
Journal of Molecular Biology, 2010 The human complement system plays an essential role in innate and adaptive immunity by marking and eliminating microbial intruders. Activation of complement on foreign surfaces results in proteolytic cleavage of complement component 3 (C3) into the potent opsonin C3b, which triggers a variety of immune responses and participates in a self-amplification
Brandon L Garcia +2 more
exaly +3 more sources
C3c intrathecal synthesis evaluation in patients with multiple sclerosis Evaluación de la síntesis intratecal de C3c en pacientes con esclerosis múltiple [PDF]
Arquivos de Neuro-Psiquiatria, 2007 INTRODUCTION: Multiple sclerosis (MS) is a chronic, inflammatory and progressive disease of the central nervous system in which local inflammatory injuries of the brain white matter appears, being the most outstanding feature the myeline loss ...
Bárbara Padilla-Docal +6 more
doaj +2 more sources