Results 11 to 20 of about 790,520 (218)

Deposition of complement C3c, immunoglobulin (Ig)G4 and IgG at the basement membrane of pancreatic ducts and acini in autoimmune pancreatitis [PDF]

Histopathology, 2010
Detlefsen S, Bräsen J H, Zamboni G, Capelli P & Klöppel G
(2010) Histopathology57, 825–835 Deposition of complement C3c, immunoglobulin (Ig)G4 and IgG at the basement membrane of pancreatic ducts and acini in autoimmune pancreatitis Aims:  Autoimmune pancreatitis (AIP) is a type of pancreatitis whose immunopathogenesis is still unknown. It has been
S. Detlefsen, J. Bräsen, G. Zamboni, P. Capelli, G. Klöppel   +4 more
semanticscholar   +7 more sources

Complement C3c and C4c as predictors of death in heart failure

IJC Metabolic & Endocrine, 2015
Background Activation of the immune system is one of the several pathways suggested as involved in Heart Failure (HF). The complement system is a key component of innate immunity.
Nuno Silva, Sandra Martins, P. Lourenço, P. Bettencourt, J. Guimarães   +4 more
semanticscholar   +5 more sources

Functional assessment of mouse complement pathway activities and quantification of C3b/C3c/iC3b in an experimental model of mouse renal ischaemia/reperfusion injury. [PDF]

Journal of Immunological Methods, 2015
The complement system is an essential component of our innate immunity, both for the protection against infections and for proper handling of dying cells. However, the complement system can also contribute to tissue injury and inflammatory responses.
J. Kotimaa, Maaike B van Werkhoven, J. O’Flynn, N. Klar‐Mohamad, J. V. van Groningen, G. Schilders, Helma Rutjes, M. Daha, M. Seelen, C. van Kooten   +9 more
semanticscholar   +6 more sources

Complement, but Not Platelets, Plays a Pivotal Role in the Outcome of Mucormycosis In Vivo

Journal of Fungi, 2023
Background: Mucormycetes, a heterogeneous group of fungi, induce a life-threatening disease called mucormycosis. Immune deficiencies represent a major risk factor; hence, we wanted to illuminate the role of complement and platelets in the defense against
Verena Harpf, Günter Rambach, Nadia Parth, Magdalena Neurauter, Verena Fleischer, Michaela Lackner, Cornelia Lass-Flörl, Reinhard Würzner, Cornelia Speth   +8 more
doaj   +2 more sources

Structure of Compstatin in Complex with Complement Component C3c Reveals a New Mechanism of Complement Inhibition [PDF]

Journal of Biological Chemistry, 2007
Undesired complement activation is a major cause of tissue injury in various pathological conditions and contributes to several immune complex diseases. Compstatin, a 13-residue peptide, is an effective inhibitor of the activation of complement component C3 and thus blocks a central and crucial step in the complement cascade.
Janssen, B.J.C., Halff, E.F., Lambris, J.D., Gros, P.   +3 more
openaire   +6 more sources

Correlation of C3c complement, NT-proBNP and Left Ventricle Ejection Fraction (LVEF) in Heart Failure [PDF]

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY, 2019
Introduction. Heart failure is a health problem in Indonesia. The 2013 Basic Health Research Data showed that the estimated heart failure in Indonesia was 530,068 people.
julious julious, Jusak Nugraha, M. Aminuddin   +2 more
semanticscholar   +2 more sources

Complement and autoantibody levels under anifrolumab therapy in SLE: implications for clinical practice [PDF]

Frontiers in Immunology
IntroductionAnifrolumab (ANI), a type I interferon receptor antagonist, has demonstrated clinical efficacy in systemic lupus erythematosus (SLE). However, its effects on serological markers commonly used to assess disease activity in clinical practice ...
Jan-Gerd Rademacher, Björn Tampe, Peter Korsten, Peter Korsten   +3 more
doaj   +2 more sources

Progressive IgA Nephropathy Is Associated With Low Circulating Mannan-Binding Lectin–Associated Serine Protease-3 (MASP-3) and Increased Glomerular Factor H–Related Protein-5 (FHR5) Deposition

Kidney International Reports, 2018
IgA nephropathy (IgAN) is characterized by glomerular deposition of galactose-deficient IgA1 and complement proteins and leads to renal impairment. Complement deposition through the alternative and lectin activation pathways is associated with renal ...
Nicholas R. Medjeral-Thomas, Anne Troldborg, Nicholas Constantinou, Hannah J. Lomax-Browne, Annette G. Hansen, Michelle Willicombe, Charles D. Pusey, H. Terence Cook, Steffen Thiel, Matthew C. Pickering   +9 more
doaj   +3 more sources

Complement Activation in Kidneys of Patients With COVID-19

Frontiers in Immunology, 2021
Most patients who became critically ill following infection with COVID-19 develop severe acute respiratory syndrome (SARS) attributed to a maladaptive or inadequate immune response.
Frederick Pfister, Eva Vonbrunn, Tajana Ries, Hans-Martin Jäck, Klaus Überla, Günter Lochnit, Ahmed Sheriff, Martin Herrmann, Maike Büttner-Herold, Kerstin Amann, Christoph Daniel   +10 more
doaj   +2 more sources

Complement activation in severely ill patients with sepsis: no relationship with inflammation and disease severity

Critical Care, 2023
Background Sepsis is characterized by a dysregulated immune response to infection. The complement system plays an important role in the host defence to pathogens.
Aline H. de Nooijer, Antigone Kotsaki, Eleftheria Kranidioti, Matthijs Kox, Peter Pickkers, Erik J. M. Toonen, Evangelos J. Giamarellos-Bourboulis, Mihai G. Netea   +7 more
doaj   +2 more sources