Results 31 to 40 of about 3,342 (187)

Overactivation of the complement system may be involved in intrarenal arteriolar lesions in IgA nephropathy

Frontiers in Medicine, 2022
IntroductionIgA nephropathy (IgAN) encompasses a wide range of clinical and histology features. Some patients present without hematuria, with or without hypertension, still rapidly progress in renal function. Renal pathology of this part of patients were
Wei-yi Guo, Xiu-ping An, Li-jun Sun, Hong-rui Dong, Wen-rong Cheng, Nan Ye, Guo-qin Wang, Xiao-yi Xu, Zhi-rui Zhao, Hong Cheng   +9 more
doaj   +1 more source

Complement Activation in Kidneys of Patients With COVID-19

Frontiers in Immunology, 2021
Most patients who became critically ill following infection with COVID-19 develop severe acute respiratory syndrome (SARS) attributed to a maladaptive or inadequate immune response.
Frederick Pfister, Eva Vonbrunn, Tajana Ries, Hans-Martin Jäck, Klaus Überla, Günter Lochnit, Ahmed Sheriff, Martin Herrmann, Maike Büttner-Herold, Kerstin Amann, Christoph Daniel   +10 more
doaj   +1 more source

Complement Components C3 and C4 Indicate Vasculitis Manifestations to Distinct Renal Compartments in ANCA-Associated Glomerulonephritis

, 2022
Acute kidney injury (AKI) is a common and severe complication of antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) causing progressive chronic kidney disease (CKD), end-stage renal disease (ESRD) or death.
Tampe, Björn, Tampe, Björn; Department of Nephrology and Rheumatology, University Medical Center Göttingen, 37075 Göttingen, Germany, bjoern.tampe@med.uni-goettingen.de, Hakroush, Samy, Korsten, Peter; Department of Nephrology and Rheumatology, University Medical Center Göttingen, 37075 Göttingen, Germany, peter.korsten@med.uni-goettingen.de, Ströbel, Philipp; Institute of Pathology, University Medical Center Göttingen, 37075 Göttingen, Germany, philipp.stroebel@med.uni-goettingen.de, Hakroush, Samy; Institute of Pathology, University Medical Center Göttingen, 37075 Göttingen, Germany, samy.hakroush@med.uni-goettingen.de, Tampe, Désirée, Tampe, Désirée; Department of Nephrology and Rheumatology, University Medical Center Göttingen, 37075 Göttingen, Germany, desiree.tampe@med.uni-goettingen.de, Korsten, Peter, Ströbel, Philipp   +9 more
core   +2 more sources

New Insights into Xenotransplantation for Cartilage Repair: Porcine Multi-Genetically Modified Chondrocytes as a Promising Cell Source

Cells, 2021
Transplantation of xenogenic porcine chondrocytes could represent a future strategy for the treatment of human articular cartilage defects. Major obstacles are humoral and cellular rejection processes triggered by xenogenic epitopes like α-1,3-Gal and ...
Hanna Tritschler, Konrad Fischer, Jochen Seissler, Jörg Fiedler, Rebecca Halbgebauer, Markus Huber-Lang, Angelika Schnieke, Rolf E. Brenner   +7 more
doaj   +1 more source

Putative salivary protein biomarkers for the diagnosis of oral lichen planus: a case-control study

BMC Oral Health, 2018
Background Salivary protein biomarkers for screening and diagnosis of oral lichen planus (OLP) are not well-defined. The objective of this study was to identify putative protein biomarkers for OLP using proteomic approaches.
Sineepat Talungchit, Waranun Buajeeb, Chotima Lerdtripop, Rudee Surarit, Kongthawat Chairatvit, Sittiruk Roytrakul, Hiroaki Kobayashi, Yuichi Izumi, Siribang-on Piboonniyom Khovidhunkit   +8 more
doaj   +1 more source

Complement in acute and chronic arthritides: assessment of C3c, C9, and protectin (CD59) in synovial membrane. [PDF]

Annals of the Rheumatic Diseases, 1996
To investigate the role of complement cascade induced damage and protection against it in acute arthritides compared to rheumatoid arthritis and other chronic joint derangements.C3c, C9, and protectin (CD59) were examined by avidin-biotin-peroxidase complex staining.Marked deposits of C3c and C9 were found in synovial vasculature and intercellular ...
Y T, Konttinen, A, Ceponis, S, Meri, A, Vuorikoski, P, Kortekangas, T, Sorsa, A, Sukura, S, Santavirta   +7 more
openaire   +2 more sources

Detection of injected anti-HS antibodies, rabbit IgG and complement C3c in mouse glomeruli after anti-GBM-induced glomerulonephritis.

, 2021
Representative immunofluorescence stainings for (A) anti-HS antibodies with anti-VSV in glomeruli of mice co-injected with anti-GBM IgG serum and anti-HS antibodies, 2 hours after injection (40x magnification), (B) Staining for rabbit IgG in glomeruli of
Toin H. van Kuppevelt (10013111), Nathalie J. H. G. Passmann (11873757), Markus A. Loeven (3368984), Jasper J. van Gemst (3368987), Bart Smeets (170582), Johan van der Vlag (45996), Jo H. Berden (11873763), Ton J. Rabelink (8695392), Angelique L. W. M. M. Rops (11873760)   +8 more
core   +1 more source

Complement component 3 and its activation split‐products in saliva associate with periodontitis [PDF]

, 2022
Background: Periodontitis (PD) is classified by Grades A through C according to the risk of further progression, PD Grade C (PD-C) being the most severe progressing form. It is a matter of controversy, whether the disease activity observed in PD-C is due
Graversen, Jonas H; id_orcid, Nielsen, Claus H, Damgaard, Christian, Nielsen, Claus H., Holmstrup, Palle, Anne Katrine Danielsen, Palle Holmstrup, Claus H. Nielsen, Palarasah, Yaseelan, Yaseelan Palarasah, Laura Massarenti, Massarenti, Laura, Christian Damgaard, Jonas H. Graversen, Graversen, Jonas H., Danielsen, Anne Katrine   +15 more
core   +1 more source

The loss of glycocalyx integrity impairs complement factor H binding and contributes to cyclosporine-induced endothelial cell injury

Frontiers in Medicine, 2023
BackgroundCalcineurin inhibitors (CNIs) are associated with nephrotoxicity, endothelial cell dysfunction, and thrombotic microangiopathy (TMA). Evolving evidence suggests an important role for complement dysregulation in the pathogenesis of CNI-induced ...
Chia Wei Teoh, Chia Wei Teoh, Chia Wei Teoh, Chia Wei Teoh, Magdalena Riedl Khursigara, Magdalena Riedl Khursigara, Magdalena Riedl Khursigara, Carolina G. Ortiz-Sandoval, Jee Woo Park, Jun Li, Arlette Bohorquez-Hernandez, Valentina Bruno, Valentina Bruno, Valentina Bruno, Emily E. Bowen, Spencer A. Freeman, Spencer A. Freeman, Lisa A. Robinson, Lisa A. Robinson, Lisa A. Robinson, Lisa A. Robinson, Christoph Licht, Christoph Licht, Christoph Licht, Christoph Licht, Christoph Licht   +25 more
doaj   +1 more source

New Technology Capabilities of Direct Antiglobulin Test

Клиническая онкогематология, 2020
Background. Direct antiglobulin test (DAT) is used to identify erythrocyte-fixed antibodies and complement components. Gel methods are applied to differentiate immunoglobulin class and subclass in positive DAT, which allows to study the nature of anemia ...
Elena Aleksandrovna Poponina, E. V. Butina, A. V. Iovdii, O. D. Maksimov, G. A. Zaitseva, I. V. Paramonov   +5 more
doaj   +1 more source