Results 51 to 60 of about 3,342 (187)

Complement Activation in the Disease Course of Coronavirus Disease 2019 and Its Effects on Clinical Outcomes

, 2021
Background: Excessive activation of immune responses in coronavirus disease 2019 (COVID-19) is considered to be related to disease severity, complications, and mortality rate.
Gerretsen, Jelle, van Schaik, Tirsa, Schraa, Kiki, van der Eng, Hetty, Jaeger, Martin, Janssen, Nico A. F., Rahamat-Langendoen, Janette, Hemelaar, Pleun, Moorlag, Simone, Debisarun, Priya, Frenzel, Tim, van Crevel, Reinout, Bleeker-Rovers, Chantal, Hoogerwerf, Jacobien, Hopman, Joost, van de Veerdonk, Frank L., Toonen, Erik J. M., Claassen, Wout, van der Hoeven, Hans, Jacobs, Cor, ten Oever, Jaap, Kouijzer, Ilse, Dijkstra, Helga, Schouten, Jeroen, van der Velde, Sjef, Taks, Esther, Grondman, Inge, Rovers, Noortje, Nijman, Gerine, Heesakkers, Hidde, Beunders, Remi, de Nooijer, Aline H., Fransman, Liz, Klop-Riehl, Margreet, Kox, Matthijs, Kooistra, Emma, Joosten, Leo A. B., Jansen, Trees, Waalders, Nicole, Lemmers, Heidi, Netea, Mihai G., Giamarellos-Bourboulis, Evangelos J., Willems, Loek, Weren, Fieke, Wertheim, Heiman, van de Maat, Josephine, Pickkers, Peter, Hijmans, Anneke, van Emst, Liesbeth, de Mast, Quirijn   +49 more
core   +3 more sources

Long‐Term Anifrolumab Treatment Normalizes Hematologic Parameters and Several Serologic Markers in Patients With Systemic Lupus Erythematosus

ACR Open Rheumatology, Volume 8, Issue 6, June 2026.
Objective To evaluate the long‐term effects of anifrolumab on hematologic and serologic parameters over four years. Methods This analysis included 536 patients with moderate‐to‐severe systemic lupus erythematosus (SLE) who received intravenous anifrolumab 300 mg (n = 358) or placebo (n = 178) in the 52‐week, phase 3 TULIP‐1/2 trials (NCT02446912 and ...
Edward M. Vital, Zahir Amoura, Kenneth C. Kalunian, Ian N. Bruce, Yoshiya Tanaka, Susan Manzi, Ihor Hupka, Jacob Knagenhjelm, Hussein Al‐Mossawi, Catharina Lindholm   +9 more
wiley   +1 more source

Effect of antigen site and complement receptor status on the rate of cleavage of C3c antigen from red cell bound C3b [PDF]

Blood, 1988
C3b was bound to human red cells when serum complement was activated by addition of antibodies directed against different red cell antigens, and the rate of cleavage to C3dg was determined by assay for loss of bound C3c antigens using radiolabeled monoclonal anti-C3c.
M S, Currie, P K, Rustagi, R, Wojcieszak, L, Ziolkowski, G D, Ross, G L, Logue   +5 more
openaire   +3 more sources

Tolerability and Feasibility of Minimally Invasive Canine Skin Sampling: Excellent Tolerability Meets Transcriptomic Challenges

Veterinary Dermatology, Volume 37, Issue 3, Page 375-385, June 2026.
ABSTRACT Background Advances in transcriptomics have driven the demand for minimally invasive, reproducible and high‐yield skin sampling methods, particularly for studying inflammatory skin diseases in companion animals. Hypothesis/Objectives We tested tolerability, feasibility and RNA quantity and quality of three minimally invasive skin sampling ...
Ina Herrmann, Lisa B. Mamo, Allison N. Dickey   +2 more
wiley   +1 more source

Microscopic Polyangiitis After Pulmonary Nontuberculous Mycobacterial Disease: A Case Report and Literature Review

Respirology Case Reports, Volume 14, Issue 5, May 2026.
This case highlights that ANCA‐associated vasculitis can emerge in patients with chronic airway disease and a history of nontuberculous mycobacterial infection, potentially masquerading as infection‐related inflammation. Early recognition based on extrapulmonary clues (urinary abnormalities and neuropathy) enabled prompt diagnosis and treatment with ...
Hidenori Takahashi, Riho Nakagawa, Mio Toyama‐Kousaka, Yugo Satake, Hiroki Nagamatsu, Ryutaro Hirose, Naoya Toba, Shinichiro Ota, Miwa Morikawa, Natsuko Nakano, Kazuyoshi Ishigaki, Masaharu Shinkai   +11 more
wiley   +1 more source

Bee Venom Alleviates Atopic Dermatitis Symptoms through the Upregulation of Decay-Accelerating Factor (DAF/CD55)

Toxins, 2019
Bee venom (BV)—a complex mixture of peptides and toxic proteins including phospholipase A2 and melittin—promotes blood clotting. In this study, we investigated the anti-atopic properties of BV and the mechanism associated with its regulation ...
Yenny Kim, Youn-Woo Lee, Hangeun Kim, Dae Kyun Chung   +3 more
doaj   +1 more source

Alternative Complement Pathway Is Activated and Associated with Galactose-Deficient IgA1 Antibody in IgA Nephropathy Patients

Frontiers in Immunology, 2021
BackgroundGalactose-deficient IgA1 (Gd-IgA1) and alternative complement pathway activation are considered to be involved in the pathogenesis of IgA nephropathy (IgAN).
Yen-Ling Chiu, Yen-Ling Chiu, Yen-Ling Chiu, Wei-Chou Lin, Kai-Hsiang Shu, Yi-Wen Fang, Fan-Chi Chang, Yu-Hsiang Chou, Ching-Fang Wu, Wen-Chih Chiang, Shuei-Liong Lin, Shuei-Liong Lin, Yung-Ming Chen, Ming-Shiou Wu   +13 more
doaj   +1 more source

Unraveling the Mystery of Melt Migration in Migmatites: From Channeling Instability to Pattern Formation

Journal of Geophysical Research: Solid Earth, Volume 131, Issue 5, May 2026.
Abstract Melt migration in partially molten rocks is commonly described by porous flow models controlled by the hydro‐mechanical compaction length, which effectively explains melt extraction at mid‐ocean ridges. However, this framework cannot account for the paradoxical accumulation of small melt fractions into rhythmic leucosome–melanosome bands in ...
Qingpei Sun, Manman Hu, Roberto Weinberg, Klaus Regenauer‐Lieb   +3 more
wiley   +1 more source

Complement Activation and Organ Damage After Trauma—Differential Immune Response Based on Surgical Treatment Strategy

Frontiers in Immunology, 2020
Background: The complement system is part of the innate immunity, is activated immediately after trauma and is associated with adult respiratory distress syndrome, acute lung injury, multiple organ failure, and with death of multiply injured patients ...
Ina Lackner, Birte Weber, Meike Baur, Giorgio Fois, Florian Gebhard, Roman Pfeifer, Paolo Cinelli, Sascha Halvachizadeh, Miriam Lipiski, Nikola Cesarovic, Hubert Schrezenmeier, Hubert Schrezenmeier, Markus Huber-Lang, Hans-Christoph Pape, Miriam Kalbitz   +14 more
doaj   +1 more source

Investigation of Potential Risks in Bio‐Based Food Contact Materials (FCMs) From Microbial Exploitation of Agricultural Wastes: Case Studies of Bacterial Cellulose and Nisin

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.
ABSTRACT In the context of the circular economy and the increasing demand for safe and sustainable packaging, this work addresses the safety assessment of food contact materials (FCMs) derived from agro‐industrial by‐products. Despite growing interest in these bio‐based materials, the literature still lacks a structured safety‐assessment framework able
Marianna Ciccone, Emmanouil Tsochatzis, Joel Armando Njieukam, Lorenzo Siroli, Davide Gottardi, Rosalba Lanciotti, Francesca Patrignani   +6 more
wiley   +1 more source