Results 161 to 170 of about 26,400 (209)

C4A copy number is associated with autoimmune disease

Nature Reviews Rheumatology, 2022
exaly   +3 more sources

C4A gene deletion: association with Graves' disease

Journal of Molecular Endocrinology, 1989
ABSTRACT The association of HLA class I and class II antigens, particularly HLA-B8,DR3, with a variety of autoimmune diseases has been well documented. The C4A*Q0 (non-expressed C4A) allele which is in linkage disequilibrium with HLA-B8,DR3 has also been reported to be associated with systemic lupus erythematosus, insulin-dependent diabetes mellitus ...
S, Ratanachaiyavong, L, Lloyd, A M, McGregor   +2 more
openaire   +2 more sources

The active site of human C4a anaphylatoxin

Molecular Immunology, 1983
The human C4 activation peptide C4a has recently been shown to be biologically active and to share common tissue receptors with human C3a anaphylatoxin. Human C3a and C4a each induce contraction and cause cross-desensitization of isolated guinea-pig ileal strips.
T E, Hugli, M S, Kawahara, C G, Unson, R, Molinar-Rode, B W, Erickson   +4 more
openaire   +2 more sources

Cellular responses of guinea-pig macrophages to C4a; inhibition of C3a-induced O2− generation by C4a

Immunology Letters, 1993
We have investigated the cellular responses of guinea-pig macrophages to human C4a. C4a induced a biphasic Ca2+ mobilization; a rapid temporary Ca2+ mobilization from intracellular Ca2+ pool followed by a weak Ca2+ influx of extracellular Ca2+. Although the C4a-treated macrophages did not respond again to C4a, that is, desensitization to C4a, the C4a ...
Y, Murakami, T, Yamamoto, T, Imamichi, S, Nagasawa   +3 more
openaire   +2 more sources

COMPLEMENT ALLOTYPING IN SLE: ASSOCIATION WITH C4A NULL

Australian and New Zealand Journal of Medicine, 1983
Abstract: Immunogenetic factors are important in systemic lupus erythematosus (SLE) and deficiency of a number of complement components is often associated with a lupuslike illness. The complement components Bf, C2 and C4 are encoded within the human major histocompatibility complex (MHC) and are polymorphic.
F T, Christiansen, R L, Dawkins, G, Uko, J, McCluskey, P H, Kay, P J, Zilko   +5 more
openaire   +2 more sources

Complement C4A, C4B and BF haplotypes in Koreans

Tissue Antigens, 1996
Specific alleles at C4A, C4B and BF loci occur in populations and are inherited in complotypes, which are linked with particular HLA haplotypes. Considerable differences in complement allele and complotype frequencies have been observed among various ethnic groups.
K S, Park, M H, Park, T, Juji, K, Tokunaga   +3 more
openaire   +2 more sources

Increased anaphylatoxins (C3a and C4a) in psoriatic sera

British Journal of Dermatology, 1985
We measured C3a and C4a anaphylatoxins in the serum of 56 psoriatic patients and 36 healthy control subjects by radioimmunoassay in order to clarify the mechanism of complement activation occurring in psoriatic lesions. Whereas a small amount of anaphylatoxins were demonstrable even in the sera of healthy adults, the serum concentrations of C3a and C4a
K, Ohkohchi, H, Takematsu, H, Tagami
openaire   +2 more sources