Results 61 to 70 of about 26,400 (209)

An Open‐Label Phase 1b Study of the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of ANX005 in Patients with Huntington's Disease

Movement Disorders, EarlyView.
Complement activation is implicated in Huntington's disease; ANX005 is a potent inhibitor of component C1q. ANX005 exhibited a generally manageable safety profile with rapid reduction in C1q in the cerebrospinal fluid. Functional ability on composite Unified Huntington's Disease Rating Scale and total functional capacity was maintained, with potential ...
Rajeev Kumar, Pinky Agarwal, Karen Anderson, Daniel Claassen, Marissa Dean, Andrew Duker, Burton Scott, Benjamin Hoehn, Ann Mongan, Ping Lin, Ellen Cahir‐McFarland, Lori Taylor, Glenn Morrison, Ted Yednock, Sanjay Keswani, Henk‐Andre Kroon   +15 more
wiley   +1 more source

1-Methyl-4-({5-[(4-methyl­phen­yl)sulfan­yl]pent­yl}sulfan­yl)benzene [PDF]

, 2009
There are two independent mol­ecules in the asymmetric unit of the title compound, C19H24S2. In both mol­ecules, the aliphatic segment of the ligand is in an all-trans conformation: the –S–(CH2)5–S–bridging chain is almost planar (r.m.s.
Brito, Iván, Cárdenas, Alejandro, Albanez, Joselyn, Bolte, Michael, López-Rodríguez, Matías   +4 more
core   +2 more sources

Unlocking n‐alk‐1‐ynes conformers: Quantum “trigger finger” versus “stiff joint” conformations

Smart Molecules, EarlyView.
Quantum chemical analysis reveals the unique function of n‐alk‐1‐yne terminus as a Quantum “Trigger Finger,” exhibiting two near‐isoenergetic conformers (Cs ${\mathrm{C}}_{s}$and C1 ${\mathrm{C}}_{1}$) locked by a symmetric high barrier. This contrasts with the lower asymmetric barrier of the conventional asymmetric “Stiff Joint” alkyl chain.
Ioan Bâldea
wiley   +1 more source

Analysis of cross-reactive neutralizing antibodies in human HFMD serum with an EV71 pseudovirus-based assay. [PDF]

PLoS ONE, 2014
Hand, foot and mouth disease, associated with enterovirus 71 (EV71) infections, has recently become an important public health issue throughout the world.
Huafei Zhang, Dong An, Wei Liu, Qunying Mao, Jun Jin, Lin Xu, Shiyang Sun, Liping Jiang, Xiaojun Li, Jie Shao, Hongxia Ma, Xueyong Huang, Shijie Guo, Haiying Chen, Tong Cheng, Lisheng Yang, Weiheng Su, Wei Kong, Zhenglun Liang, Chunlai Jiang   +19 more
doaj   +1 more source

Multi-lectin Affinity Chromatography and Quantitative Proteomic Analysis Reveal Differential Glycoform Levels between Prostate Cancer and Benign Prostatic Hyperplasia Sera. [PDF]

, 2018
Currently prostate-specific antigen is used for prostate cancer (PCa) screening, however it lacks the necessary specificity for differentiating PCa from other diseases of the prostate such as benign prostatic hyperplasia (BPH), presenting a clinical need
Adusumilli, Ravali, Brooks, James D, Kullolli, Majlinda, Mallick, Parag, Pitteri, Sharon J, Tanimoto, Cheylene, Totten, Sarah M   +6 more
core   +2 more sources

Fertilization influences overyielding through dominance of species with high specific leaf area in young tree mixtures

Functional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract In the context of anthropogenic eutrophication of the biosphere, understanding the impact of nutrient addition on plant diversity–productivity relationships remains a major challenge.
Dai F. Saito, Friderike Beyer, Grégoire T. Freschet, Anja Klingler, Charles A. Nock, Peter B. Reich, Michael Scherer‐Lorenzen, Jürgen Bauhus   +7 more
wiley   +1 more source

Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients. [PDF]

PLoS ONE, 2014
BackgroundNon-tuberculous mycobacteria (NTM) are ubiquitous in the environment and they infect mainly persons with underlying pulmonary diseases but also previously healthy elderly women.
Hannele Kotilainen, Marja-Liisa Lokki, Riitta Paakkanen, Mikko Seppänen, Pentti Tukiainen, Seppo Meri, Tuija Poussa, Jussi Eskola, Ville Valtonen, Asko Järvinen   +9 more
doaj   +1 more source

Variants at the MHC Region Associate With Susceptibility to Clostridioides difficile Infection: A Genome-Wide Association Study Using Comprehensive Electronic Health Records

Frontiers in Immunology, 2021
BackgroundClostridioides difficile is a major cause of healthcare-associated and community-acquired diarrhea. Host genetic susceptibility to Clostridioides difficile infection has not been studied on a large-scale.MethodsA total of 1,160 Clostridioides ...
Jiang Li, Yanfei Zhang, Alexandria L. Jilg, Donna M. Wolk, Harshit S. Khara, Amy Kolinovsky, David D. K. Rolston, Raquel Hontecillas, Josep Bassaganya-Riera, Marc S. Williams, Vida Abedi, Ming Ta Michael Lee   +11 more
doaj   +1 more source

Type I and II Interferons Drive Abacavir Hypersensitivity via Treg Suppression and T‐Cell Enhancement in Immunocompetent HLA‐Transgenic Mice

Allergy, EarlyView.
Upregulated HLA‐B*57:01 expression in Tg/KO mice amplifies abacavir‐specific CD8+ T‐cell activation, driven by enhanced antigen presentation. Abacavir treatment induces robust pDC expansion and IFN‐α production, which selectively suppresses memory Treg populations.
SuJin Hwang, Telly Sepahpour, Stephanie Kortchak, Kirthiram Krishnaveni Sivakumar, Spyros Karaiskos, Ngoc Pham, Yura Jang, Montserrat Puig, Michael Norcross   +8 more
wiley   +1 more source

QCD threshold corrections to di-lepton and Higgs rapidity distributions beyond N${}^2$LO

, 2006
We present threshold enhanced QCD corrections to rapidity distributions of di-leptons in the Drell-Yan process and of Higgs particles in both gluon fusion and bottom quark annihilation processes using Sudakov resummed cross sections.
Abe, Affolder, Affolder, Altarelli, Altarelli, Alvero, Anastasiou, Anastasiou, Anastasiou, Anastasiou, Aybat, Aybat, Barate, Blumlein, Blumlein, Blumlein, Blumlein, Bozzi, Cafarella, Catani, Catani, Catani, Chetyrkin, Collins, Contopanagos, Dawson, de Florian, Dittmar, Djouadi, Djouadi, Djouadi, Dokshitzer, Drell, Drell, Eynck, Field, Field, Glosser, Hamberg, Hamberg, Harlander, Harlander, Harlander, Humpert, Idilbi, J. Smith, Kodaira, Kubar-Andre, Laenen, Laenen, Martin, Martin, Mathews, Matsuura, Matsuura, Moch, Moch, Moch, Moch, Moch, Mueller, Mukherjee, Patwa, Ravindran, Ravindran, Ravindran, Ravindran, Ravindran, Rijken, Sen, Spira, Sterman, Sudakov, V. Ravindran, van Ritbergen, Vermaseren, Vogt, Vogt, W.L. van Neerven   +78 more
core   +1 more source