Results 131 to 140 of about 4,761 (177)
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Stereoselective Synthesis of the C31−C40/C43−C52 Unit of Amphidinol 3
The Journal of Organic Chemistry, 2009A concise synthesis of a tetrahydropyran ring system corresponding to the C31-C40 and C43-C52 units of amphidinol 3 is described. Successive chemoselective reactions, i.e., cross-metathesis to differentiate the iodoolefin from the terminal olefin and Sharpless asymmetric dihydroxylation on the resulting E-olefin, resulted in expeditious synthesis of an
Mitsunori, Kanemoto +2 more
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Abstract C52: Induction of homologous recombination by DNA nicks
Cancer Research, 2013Abstract Homologous recombination (HR) is a major mechanism of DNA repair, such that mutations in HR genes are associated with tumor susceptibility. We have used a recently adapted system for genome engineering to study HR mechanisms in mammalian cells.
Lianne E.M. Vriend +2 more
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Abstract C52: A novel combinatorial treatment for glioblastoma of temozolomide and JLK1486.
Molecular Cancer Therapeutics, 2013Abstract Background: Glioblastoma multiforme (GBM) is a grade IV brain tumor characterized by a heterogeneous population of cells that are highly invasive and resistant to chemotherapeutic treatments. The current standard of care, comprised of surgical resection followed by radiation and chemotherapy, only provides GBM patients with a 12-
Jessica L. Weatherbee +3 more
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C52-23 Pneumopericardium: An Elusive Diagnosis in the Polytrauma Patient
American Journal of Respiratory and Critical Care MedicineAbstract Pneumopericardium refers to the presence of air or gas within the pericardial sac. It most commonly results from a fistulous connection between the pericardium and air-containing structures like the thoracic cavity or GI tract, though congenital causes exist. Approximately 60% of cases are trauma-related, predominantly due to
L Mead, R Ringersen, S Gray, B Dieudonne
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Abstract C52: Collagen-mediated chromatin remodeling promotes chemoresistance in pancreatic cancer
Cancer Research, 2011Abstract Pancreatic ductal adenocarcinoma (PDAC), the fourth leading cause of cancer-related deaths in the U.S., is associated with a pronounced collagenrich stromal reaction that has been shown to contribute to chemoresistance. We recently published that PDAC cells grown in the collagen microenvironment are resistant to gemcitabine ...
Surabhi Y. Danqi-Garimella +1 more
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C52-20 Large Tension Pneumothorax Resulting in Stress Cardiomyopathy
American Journal of Respiratory and Critical Care MedicineAbstract Introduction Tension pneumothorax is a rare complication of pneumothoraces in which elevated pleural pressures can cause hemodynamic compromise. If not promptly recognized and treated, tension pneumothorax has high morbidity and mortality.
S S Bhat, R Ruggiero
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A C-Glycosidation Approach to the Central Core of Amphidinol 3: Synthesis of the C39−C52 Fragment
Organic Letters, 2005[reaction: see text] A concise route to an advance precursor (3) of the central core of amphidinol 3, a natural occurring polyketide, has been developed by applying a reductive lithiation as key step. The origin of the diastereoselectivity of this reaction was comprehensively studied for nucleophilic C-glycoside donor 5 and differently protected ...
Javier, de Vicente +2 more
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The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements. They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
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The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements. They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
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C52-11 Spinal Cord Ischemia Following Cardiac Arrest
American Journal of Respiratory and Critical Care MedicineAbstract A 24-year-old male with a history of type 1 diabetes mellitus presented to the emergency department with altered mental status, tachypnea, and bradycardia. Shortly following his arrival, the patient suffered a cardiac arrest with 15 minutes of downtime.
A Adivi, O Hasan, I Isaac
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