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Synthesis of the C42–C52 part of ciguatoxin CTX3C

Tetrahedron Letters, 2005
Abstract The C42–C52 part of ciguatoxin CTX3C ( 1 ) was synthesized from tri-O-acetyl d -glucal. The synthetic segment had a tetrahydropyran ring corresponding to the ‘C49-reduced’ L-ring of 1 , designed to avoid side reactions due to acid-labile C49 acetal carbon during acidic reductive conditions planned in further synthesis toward 1 .
Daisuke Domon   +8 more
openaire   +1 more source

Abstract C52: Enhancing the activities of endogenous antibodies.

Molecular Cancer Therapeutics, 2011
Abstract Many monoclonal antibodies (mAbs) exhibit activity through antibody dependent cellular cytotoxicity (ADCC), due to the binding interactions between the Fc portion of the mAb and Fc RIIIa on natural killer cells, macrophages and neutrophils.
Stephen Alley   +6 more
openaire   +1 more source

The carbon pentamer dication C52+: Toward thermochemical stability

The Journal of Chemical Physics, 2003
Various computational ab-initio methods are employed to study the doubly-charged carbon system C52+. For its electronic ground state, equilibrium geometries are identified, and their stability against dissociation investigated. Multireference configuration-interaction results indicate a weakly bound but thermochemically stable dication.
H. Hogreve, A. F. Jalbout
openaire   +1 more source

Stereoselective Synthesis of the C31−C40/C43−C52 Unit of Amphidinol 3

The Journal of Organic Chemistry, 2009
A concise synthesis of a tetrahydropyran ring system corresponding to the C31-C40 and C43-C52 units of amphidinol 3 is described. Successive chemoselective reactions, i.e., cross-metathesis to differentiate the iodoolefin from the terminal olefin and Sharpless asymmetric dihydroxylation on the resulting E-olefin, resulted in expeditious synthesis of an
Mitsunori, Kanemoto   +2 more
openaire   +2 more sources

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