Results 111 to 120 of about 9,658 (171)

Pathogenic determinants and mechanisms of ALS/FTD linked to hexanucleotide repeat expansions in the C9orf72 gene. [PDF]

, 2017
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two apparently distinct neurodegenerative diseases, the former characterized by selective loss of motor neurons in the brain and spinal cord and the latter characterized by ...
Wen, Xinmei, Westergard, Thomas, Pasinelli, Piera, Trotti, Davide   +3 more
core   +1 more source

Molecular Mechanisms of C9ORF72-linked Frontotemporal Dementia and Amyotrophic Lateral Sclerosis [PDF]

, 2019
Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are two devastating neurological disorders that share clinical, genetic and pathological overlap.
Riemslagh, Fenne, Riemslagh, F.W. (Fenne)   +1 more
core  

Author Correction: Autoimmune response to C9orf72 protein in amyotrophic lateral sclerosis. [PDF]

Nature
Michaelis T, Lindestam Arlehamn CS, Johansson E, Frazier A, Williams GP, Berry JD, Cudkowicz M, Goyal NA, Fournier C, Snyder A, Kwan JY, Crook J, Phillips EJ, Mallal SA, Ravits J, Marder KS, Sidney J, Sulzer D, Sette A.   +18 more
europepmc   +1 more source

Global transcriptional changes across multiple isogenic <i>C9orf72</i> patient iPSC-derived neurons. [PDF]

iScience
Sreeram A, Baron DM, Brusati A, Stallworth K, Humphrey J, Landers JE.   +5 more
europepmc   +1 more source

Innate immune crosstalk in ALS/FTD pathogenesis. [PDF]

Cell Insight
Shu X, Yu X, Xu P, Wang A.
europepmc   +1 more source

Composite grey matter fingerprints for genetic frontotemporal dementia. [PDF]

J Neurol Neurosurg Psychiatry
Bouzigues A, Campana G, Joulot M, Gensollen N, Russell LL, Foster PH, Ferry-Bolder E, Van Swieten JC, Jiskoot LC, Seelaar H, Sánchez-Valle R, Laforce R, Graff C, Galimberti D, Vandenberghe R, de Mendonca A, Tiraboschi P, Santana I, Gerhard A, Levin J, Sorbi S, Otto M, Bertoux M, Lebouvier T, Ducharme S, Butler C, Finger E, Tartaglia MC, Masellis M, Rowe JB, Synofzik M, Moreno F, Borroni B, Leber I, Zanusso G, Rohrer JD, Migliaccio R, GENetic Frontotemporal dementia Initiative (GENFI).   +37 more
europepmc   +1 more source

From Mutation to Manifestation: Penetrance in Amyotrophic Lateral Sclerosis. [PDF]

Genes (Basel)
Richard E, Al-Hajj Vourc'h S, Marouillat S, Beltran S, Blasco H, Corcia P, Vourc'h P.   +6 more
europepmc   +1 more source

Characterization of a C9orf72 Knockout Danio rerio model for ALS and cross-species validation of potential therapeutics screened in Caenorhabditis elegans. [PDF]

PLoS One
Emond A, Laflamme C, Therrien M, Liao M, Maios C, Labarre A, Drapeau P, Parker JA.   +7 more
europepmc   +1 more source

Hyperoside protects against poly-GR-mediated neurodegeneration via regulation of mitochondrial fission and oxidative stress in C9orf72-associated ALS. [PDF]

Chin Med
Hsieh WC, Lin CY, Wu HC, Weng EF, Wang SM.   +4 more
europepmc   +1 more source

VAPB confers selective neuroprotection by driving autophagic degradation of pathogenic aggregates in ALS. [PDF]

Acta Neuropathol Commun
Tripathi P, Guo H, Yamoah A, Mathur R, Doukas P, Dreser A, Jesse CM, Aronica E, Hermann A, Steinbusch H, Brook GA, Weis J, Goswami A.   +12 more
europepmc   +1 more source