Results 101 to 110 of about 180,219 (298)

Purification and Characterization of the CA 125 Tumor-Associated Antigen from Human Ascites

Tumor Biology, 1993
CA 125 is an antigenic determinant associated with epithelial ovarian carcinomas, which is recognized by a monoclonal antibody, OC 125. The biochemical structure, the immunological characteristics and the physiological function of CA 125 are unknown, principally because the molecule expressing it has not been purified to homogeneity.
M T, de los Frailes, S, Stark, W, Jaeger, A, Hoerauf, L, Wildt   +4 more
openaire   +2 more sources

CD44‐Targeting Hydroxyapatite Nanoparticles (HAP) Induce Mitochondrial Dysfunction‐Driven PANoptosis and Immunogenic Cell Death (ICD) via Ca Overload in Colorectal Cancer

Advanced Science, EarlyView.
ABSTRACT Colorectal cancer (CRC) remains therapeutically challenging due to high metastasis, recurrence, and immunotherapy resistance driven by tumor microenvironment‐mediated immune evasion. Immunogenic cell death (ICD) offers a promising strategy to reshape the immune microenvironment, yet existing ICD inducers suffer from poor targeting efficiency ...
Yao Xiao, Yuxuan Yang, Haosen Qiu, Jia Yang, Hao Liang, Zhaojun Jiang, Xiao Tong, Yongying Li, Qunfeng Huang, Jiaming Wu, Tian Lin, Jiang Yu, Min Liang   +12 more
wiley   +1 more source

The Role of CA‐125 in the Management of Ovarian Cancer: A Systematic Review

Cancer Reports
Background Ovarian cancer is frequently occurring and fatal for women. CA‐125 is important in the screening, diagnosis, and treatment of ovarian cancer.
Zohre Momenimovahed, Afrooz Mazidimoradi, Leila Allahqoli, Hamid Salehiniya   +3 more
doaj   +1 more source

Detection of cancer antigens (CA-125) using gold nano particles on interdigitated electrode-based microfluidic biosensor

Nano Convergence, 2019
Integrating microfluidics with biosensors is of great research interest with the increasing trend of lab-on-the chip and point-of-care devices. Though there have been numerous studies performed relating microfluidics to the biosensing mechanisms, the ...
Bharath Babu Nunna, Debdyuti Mandal, Joo Un Lee, Harsimranjit Singh, Shiqiang Zhuang, Durgamadhab Misra, Md Nasir Uddin Bhuyian, Eon Soo Lee   +7 more
doaj   +1 more source

Characterization of Antibodies to CA 125 that Bind Preferentially to the Cell-Associated Form of the Antigen

Tumor Biology, 2006
Antibodies to CA 125 have been used to predict relapse of ovarian cancer, but have performed poorly as therapeutic agents. One rationale for this is antibody binding to circulating shed antigen. Our aim in this study was to develop antibodies to human CA 125 that have enhanced selectivity for the cell-associated form of the antigen.Monoclonal ...
Judith, Singleton, Darlene E, Guillen, Michael S, Scully, Jiyan, Xue, Jennifer, Moffet, Chaoyuan, Chen, Sima R, Patel, Adriane, Schilling, Susanne, Corisdeo, Qifeng, Yang, Baiyang, Wang, Daniel A, Soltis, Earl F, Albone   +12 more
openaire   +2 more sources

The RNA‐Binding Protein PARN Remodeled 3′ UTR Structure Defines Poly(A)‐Loading Sites to Mediate Immunoglobulin Homeostasis

Advanced Science, EarlyView.
ABSTRACT Class Switch Recombination (CSR) is essential for generating high‐affinity antibody isotypes from IgM during adaptive humoral responses. Despite well‐established roles for various transcription factors, whether CSR is subject to dedicated post‐transcriptional control represents a significant gap in knowledge.
Siyuan Sun, Chen Yang, Xiaoyu Wang, Naijing Hu, Shengyao Zhang, Xinchun Li, Yu Chen, Jianan Zhai, Xiangfeng Tang, Wei Lu, Chenxu Lu, Changchang Cao, Weiru Yu, Wenhao Wu, Xiaonan Nie, Fengchao Wang, Bing Fang, Fazheng Ren, Yixuan Li, Juan Chen   +19 more
wiley   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Tumour biomarkers in heart failure: is there a role for CA-125?

, 2011
Tumour markers are used for the screening, diagnosis, and stratification of cancer disease. Recently, the potential role of some tumour markers has also been explored in the context of heart failure.
Maria Nikolaou, Nikolaou, Maria, YILMAZ, MEHMET BİRHAN, Alain Cohen Solal, Mehmet Birhan Yilmaz, Solal, Alain Cohen   +5 more
core   +1 more source

Cholesterol‐Mediated Metabolic‐mechanotransductive Crosstalk Orchestrates Castration Resistance in Prostate Cancer

Advanced Science, EarlyView.
Full androgen deprivation (FAD) induces paracrine cholesterol in prostate cancer that drives the polarization of cancer‐associated fibroblasts (CAFs) and subsequent elevated matrix stiffness. Matrix stiffness in turn potentiates tumor cell survival under FAD pressure via dual mechanotransductive activation of the IRE1α‐XBP1s stress‐response axis ...
Shaojie Liu, Chao Xu, Jun Jiang, Limin He, Yike Zhou, Zhengxuan Li, Yu Li, Keying Zhang, Fa Yang, Tong Lu, Hongtao Song, Hai Zhu, Zhihao Hu, Xiaolong Zhao, Kai Gan, Hongji Li, Bo Yang, Rui Zhang, Weihong Wen, Donghui Han, Weijun Qin   +20 more
wiley   +1 more source

CA 125 in peritoneal fluid: Reliable values at high dilutions.

, 1992
Forty-three samples of peritoneal fluid from women undergoing laparotomy or laparoscopy for various gynecologic diseases were examined to determine and characterize CA 125 antigen. The data were compared with the corresponding serum levels. CA 125 levels
BARBATI, Antonella, DI RENZO, Giancarlo, E. V. Cosmi, M. Anceschi   +3 more
core