Results 61 to 70 of about 2,529,224 (293)

A Generative Neuro‐Symbolic AI for Protein Sequence Design

Advanced Science, EarlyView.
We introduce EffieDes, a neuro‐symbolic framework coupling deep learning‐based fitness landscape parameterization with exact automated reasoning. Unlike greedy sampling, EffieDes identifies sequences that globally optimize fitness while satisfying intricate design constraints.
Marianne Defresne, Delphine Dessaux, Samuel Buchet, Lucie Barthe, Liza Ammar‐Khodja, Bessam Azizi, Valentin Durante, Gianluca Cioci, Simon de Givry, Alain Roussel, Luis F. Garcia‐Alles, Thomas Schiex, Sophie Barbe   +12 more
wiley   +1 more source

Ovarian cancer antigen CA 125 levels in pelvic inflammatory disease and pregnancy [PDF]

Cancer, 1986
Circulating CA 125 levels were studied in patients with gynecologic cancer and pelvic inflammatory disease, and in pregnant women. The CA 125 level was elevated (greater than 35 U/ml) in 69% (9/13) of patients with active ovarian cancer, in 32% (7/22) of patients with active cervical or endometrial cancer, in 24% (11/46) of pregnant women, and in 33 ...
H, Halila, U H, Stenman, M, Seppälä
openaire   +2 more sources

Sustained Delivery of a Shingles Subunit Vaccine Overcomes Age‐Related Declines in Humoral and Cellular Immunity Relative to Shingrix

Advanced Science, EarlyView.
Sustained delivery of a shingles subunit vaccine from an injectable polymer–nanoparticle hydrogel enhanced the potency, durability, and breadth of immune responses in aged mice while minimizing inflammatory cytokine production and reactogenicity. This strategy decouples immunogenicity from reactogenicity and offers a promising approach to improve ...
Ye Eun Song, Jerry Yan, Ben S. Ou, Olivia M. Saouaf, Noah Eckman, E. A. Appel   +5 more
wiley   +1 more source

Is Ovarian Mass Malignancy Prediction Accuracy Increased by Adding Serum CA125 Measurement to Sonographic Findings?

پزشکی بالینی ابن سینا, 2012
Introduction & Objective: The aim of the present study is to determine the accuracy of malignancy prediction in adnexal mass if CA125 measurement is added to sonographic findings.Materials & Methods: In a cross sectional study, AUC of ROC Curve of ...
Maliheh Arab, Maryam Maktabi, Hanieh Zham, Parichehr Kimiaei, Shirin Davalo   +4 more
doaj  

Diagnostic Value of Serum Cancer Antigen 125, Carcinoembryonic Antigen, Cancer Antigen 19-9, Anti Müllerian Hormone, White Blood Cell Count, Platelet Count, and Neutrophil to Lymphocyte Ratio in Endometriosis: A Retrospective Study [PDF]

International Journal of Fertility and Sterility
Background: Endometriosis is among the leading causes of morbidity in the female population worldwide. Currently, the definite diagnosis of endometriosis depends on laparoscopy as the gold-standard method.
Behnaz Nouri, Niki Talebian, Ladan Kharaz, Mahdi Falah Tafti   +3 more
doaj   +1 more source

[Cancer antigen CA 125 in ovarian cancer].

Ginekologia polska, 2004
To estimate the diagnostic and prognostic value, pathological and clinical correlation of cancer antigen 125 (CA125) in ovarian cancer (OC). Retrospective analysis was done of 350 patients who were operated for OC in years 1990-2001 in Gynecology Clinic MU of Gdansk. We analyzed those before primary operation (PO) and second look laparotomy (SLL).
Jarosław, Debniak, Maciej, Stukan, Małgorzata, Pietrzak-Stukan, Dagmara, Klasa-Mazurkiewicz   +3 more
openaire   +1 more source

Cell‐Selective Delivery of RIBOTACs via an Anti‐EGFR Nanobody for Pancreatic Cancer Treatment

Advanced Science, EarlyView.
This study introduces an innovative strategy for the tumor‐selective catalytic degradation of oncogenic non‐coding RNA by interfacing a ribonuclease‐recruiting small molecule (RIBOTAC) with an EGFR‐targeting nanobody via a CTSB (Cathepsin B)‐responsive linker.
Tianli Luo, Yijuan Wang, Dengwang Chen, Yinghan Zhang, Yi Shuai, Hualiang Yao, Tao Jiang, Hang Jiang, Ming Zhong, Xiangeng Wang, Ziwei Wang, Chenchen Xu, Ajay Goel, Hoi Tang MA, Feng Gao, Xin Wang   +15 more
wiley   +1 more source

Ubiquitination of ACSL4 by Parkin Suppresses Ferroptosis and Rescues Glucocorticoid‐Induced Bone Loss

Advanced Science, EarlyView.
GCs reduce Parkin, leading to ACSL4 accumulation and PUFA‐phospholipid‐driven ferroptosis in BMSCs, which impairs osteogenesis and promotes adipogenesis, causing GIOP. Parkin restoration (via OE‐Parkin or Parkin‐LNP@DSS6) ubiquitinates and degrades ACSL4, inhibiting ferroptosis, rescuing bone formation, and rescues GIOP bone loss.
Li‐jiang Han, Jian‐sen Miao, Yi‐feng Shi, Yi‐ting Tu, Yu‐zhe Lin, Lin‐Jie Chen, Bing‐hao Lin, Hua‐lin Li, Xuan‐qi Zheng, Hong‐qiang Wu, Hai‐xiao Liu, Lei Yang, Ai‐min Wu, Zhen Lin, Jian Xiao, Gang Zheng, Chen Jin   +16 more
wiley   +1 more source

QRICH1 Disrupts Endoplasmic Reticulum Homeostasis and Amplifies NF‐κB Signaling in Periodontal Ligament Stem Cells to Exacerbate Diabetic Periodontitis

Advanced Science, EarlyView.
QRICH1 has been established as a key factor contributing to impaired osteogenic potential and accelerated apoptosis of PDLSCs in diabetic periodontitis. QRICH1 not only significantly enhances UPR‐associated apoptotic signaling but also amplifies NF‐κB‐mediated inflammatory responses. Its inhibition restores osteogenic capacity and reduces alveolar bone
Han Li, Xiaoyu Yang, He Wang, Yunchun Kuang, Yiyao Hu, Houxuan Li, Shuhong Li, Deping Zeng, Jie Li, Jinlin Song   +9 more
wiley   +1 more source

Serum CA 125, carcinoembryonic antigen, and CA 19-9 as tumor markers in borderline ovarian tumors

, 2000
Objectives. The goals of this study were to analyze preoperative serum levels of CA 125, carcinoembryonic antigen (CEA), and CA 19-9 in patients with borderline ovarian tumors and to investigate if routine assessment of these markers in follow-up may ...
van der Zee, AGJ, ten Koor, KA, Engelen, MJA, Willemse, PHB, Hollema, H, de Bruijn, HWA, Aalders, JG   +6 more
core   +1 more source