Results 101 to 110 of about 42,942 (233)

Doppel as an early‐stage biomarker promoting EMT and dissemination in ovarian cancers

International Journal of Cancer, Volume 158, Issue 6, Page 1755-1768, 15 March 2026.
What's new? Existing biomarkers for ovarian cancer (OC) lack the sensitivity and specificity needed to consistently distinguish the malignancy from non‐ovarian influences and other cancers. Here, the authors explored the ability of the prion‐like protein Doppel, normally found in the male testes, to detect OC.
Zulfikar Azam, Xiaojun Zhang, Riajul Wahab, Md Mahedi Hasan, Shivaniben Dhadhal, Bowon Kang, Md Mynul Hassan, Mazharul Karim, Jeong Uk Choi, Muhit Rana, Jian‐Ying Zhang, Sourav Roy, Youngro Byun, In‐San Kim, Jae Yun Song, Eugene P. Toy, Sireesha Y. Reddy, Farzana Alam, Taslim A. Al‐Hilal   +18 more
wiley   +1 more source

PARP inhibition: a promising therapeutic target in ovarian cancer [PDF]

, 2015
Ovarian cancer is burdened by the highest mortality rate among gynecological cancers. Gold standard is represented by the association of platinum-taxane -based chemotherapy and radical surgery.
Abdul Halim, T, BENEDETTI PANICI, PIERLUIGI, CASORELLI, ASSUNTA, DI DONATO, VIOLANTE, DOMENICI, LAVINIA, GASPARRI, MARIALUISA, IMPERIALE, LUDOVICA, MARCHETTI, CLAUDIA, MONTI, Marco, MUSELLA, ANGELA, MUZII, LUDOVICO, PALAIA, INNOCENZA, PECORINI, Francesco, RUSCITO, ILARY, SALERNO, LAURA   +14 more
core   +1 more source

Ovarialkarzinom: präoperatives CA125 als Prognosemarker [PDF]

gynäkologie + geburtshilfe, 2012
Bei den malignen epithelialen Ovarialtumoren lassen sich diejenigen mit niedrigem Malignitatspotenzial abgrenzen. Bei der Beurteilung des Therapieerfolges im Sinne einer 5-Jahres-Rezidivfreiheit und 5-Jahres-Gesamtuberlebenszeit erwiesen sich erhohte CA125-Spiegel als unabhangiger prognostischer Biomarker.
openaire   +2 more sources

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, Volume 20, Issue 3, Page 838-849, March 2026.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Two Cases of Macroglobulinemia with Elevated Serum CA125: Case Reports and Literature Review

Cancer Management and Research
Huiying Zhao,1,* Ling Qin,2,* Geng Wang,1 Jianying Li,1 Yuan Huang,1 Jie Niu,1 Xuzhen Qin1 1Department of Laboratory Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of ...
Zhao H, Qin L, Wang G, Li J, Huang Y, Niu J, Qin X   +6 more
doaj  

Red Blood Cells Internalize Extracellular DNA via Apoptotic Bodies with Clinical Relevance to Cancer Patients

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Mature red blood cells (RBCs) can capture extracellular DNA, with short fragments homologous to cfDNA. This uptake is mediated by apoptotic bodies, which induce RBC oxidative stress, deformation, and accelerated in vivo clearance. The rbcDNA abundance correlates with tumor burden and therapeutic response, highlighting its potential as a liquid biopsy ...
Zihang Zeng, Zongbi Yi, Jing Hu, Jiali Li, Yu Xu, Xiuli Guo, Qian Ji, Kaixiang Feng, Ying Zhang, Sirui Bai, Yushuang Tan, Yufei Yan, Linzhi Han, Jing Jiang, Tengfei Wang, Xiang Wang, Ziqing Zhan, Ruiying Huang, Jinfang Zhang, Conghua Xie, Binghe Xu   +20 more
wiley   +1 more source

Risk of Breast and Ovarian Cancer After Prophylactic Mastectomy and Salpingo‐Oophorectomy in BRCA1/2 Germline Variant Carriers: A Retrospective Cohort Study From a Single German Center

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT Background As the data on BRCA1/2‐associated breast and ovarian cancer prevalence after prophylactic surgery has not been exhaustively investigated yet, we aimed to evaluate the cancer prevalence in a single center cohort of BRCA1 and BRCA2 carriers after conducting prophylactic mastectomy, as well as prophylactic bilateral salpingo ...
Sara Mendes, Maryam Yahiaoui‐Doktor, Eva Maria Fallenberg, Marion Kiechle, Sabine Grill   +4 more
wiley   +1 more source

Relationship of Tumor Markers and Hilar Lymph Nodes with Bone Metastasis of Whole Body Bone Imaging in Lung Adenocarcinoma

Zhongliu Fangzhi Yanjiu, 2019
Objective To investigate the relationship between tumor markers of lung cancer and bone metastasis of whole body bone imaging in lung adenocarcinoma. Methods The whole body bone imaging of 278 patients diagnosed as lung adenocarcinoma in our hospital was
CAO Zhongnian, ZHENG Rong, WEI Zhengmao, HONG Hao, GUAN Zhimei, LI Yuhuan   +5 more
doaj   +1 more source

Gynaecological surveillance in high risk women [PDF]

, 2016
Increasing availability of genetic testing and falling costs of the tests suggests that growing numbers of unaffected women will be identified worldwide who are at increased risk of gynaecological malignancies.
Dilley, J, Gentry-Maharaj, A, Menon, U
core  

MUC16/CA125 in cancer: new advances

Clinica Chimica Acta
MUC16/CA125 is a common diagnostic marker for many types of cancer. However, due to the widespread expression of MUC16 in cancer, its specificity and sensitivity as a target are poor, which severely limits its clinical application. In recent years, various studies have shown that the clinical application potential of MUC16/CA125 has been greatly ...
Xin-Yu, Zhang, Lian-Lian, Hong, Zhi-Qiang, Ling   +2 more
openaire   +2 more sources