Results 101 to 110 of about 31,767 (201)

Graded Ca2+/calmodulin-dependent coupling of voltage-gated CaV1.2 channels

eLife, 2015
In the heart, reliable activation of Ca2+ release from the sarcoplasmic reticulum during the plateau of the ventricular action potential requires synchronous opening of multiple CaV1.2 channels.
Rose E Dixon, Claudia M Moreno, Can Yuan, Ximena Opitz-Araya, Marc D Binder, Manuel F Navedo, Luis F Santana   +6 more
doaj   +1 more source

Mechanoactive Biomaterials for Cell–Matrix Mechanotransduction

Advanced Materials, EarlyView.
The graphical abstract shows how individual triggers (force, light, or temperature) and combined optothermal or receptor‐targeted actuation induce material responses at the tissue, cellular, and receptor scales. Their spatial (global or focused) and temporal (continuous or cyclic) modulation determines the resulting mechanical output.
Yi‐Tung Lu, Alison E. John, Marc A. Fernández‐Yagüe   +2 more
wiley   +1 more source

The Antiallodynic Action Target of Intrathecal Gabapentin: Ca2+ Channels, K-Atp Channels or N-Methyl-D-Aspartic Acid Receptors?

, 2009
Gabapentin is a novel analgesic whose mechanism of action is not known. We investigated in a postoperative pain model whether adenosine triphosphate (ATP)sensitive K+ (K-ATP) channels, N-methyl-D-aspartic acid (NMDA) receptors, and Ca2 + channels are ...
鄭仁坤;邱麗珠, CHENG, JEN-KUN;CHIOU, LIH-CHU   +1 more
core  

Near‐Infrared Imaging of H2O2 in Plants With Nanosensors Under Environmentally Changing Conditions

Advanced Materials, EarlyView.
This paper reports a ratiometric nanosensor enabling robust, multivariate detection of stress signals (H2O2) in plants, with high resistance to light fluctuations and mechanical disturbances. Single‐walled carbon nanotubes serve as the sensor, Egyptian Blue nanosheets serve as a stable reference, and plant autofluorescence serves as a label‐free ...
Jiaqi Li, Bjoern F. Hill, Chen Ma, Juliana Gretz, Tanuja Kistwal, Janus A. C. Wartmann, Justus T. Metternich, Juan Pablo Giraldo, Sebastian Kruss   +8 more
wiley   +1 more source

Reduced Graphene Oxide Enhances the Vascular Organization and Contractile Performance of Fibrin‐Gelatin‐Based Engineered Cardiac Tissue

Advanced Materials Interfaces, EarlyView.
Fibrin–gelatin hydrogels functionalized with reduced graphene oxide create a mechanically stable and bioactive 3D environment for engineered cardiac tissue. The composite matrix promotes endothelial lumen formation, enhances sarcomeric protein expression, and increases contractile performance of embedded cardiomyocytes.
Christoph Kuckelkorn, Marie Baiker, Yajuan Jiang, Ebru Aksoy, Kurt Pfannkuche, Horst Fischer   +5 more
wiley   +1 more source

TRP channels: a provocative rationalization for local Ca2+ control in arterial tone development

Frontiers in Physiology
Arterial networks are controlled by the consolidated output of stimuli that set “how much” (magnitude) and “where” (distribution) blood flow is delivered.
Mohammed A. El-Lakany, Mohammed A. El-Lakany, Donald G. Welsh   +2 more
doaj   +1 more source

Local uncaging of caged Ca2+ reveals distribution of Ca2+-activated Cl- channels in pancreatic acinar cells

, 2001
In exocrine acinar cells, Ca2+-activated Cl− channels in the apical membrane are essential for fluid secretion, but it is unclear whether such channels are important for Cl− uptake at the base.
Lomax, Richard B., Tepikin, Alexei V., Petersen, Ole Holger, Park, Myoung Kyu   +3 more
core   +1 more source

Microfluidic Droplet Plate Preserving Single Human Induced Pluripotent Stem Cell‐Derived Cardiomyocytes Morphology and Function

Advanced Materials Technologies, EarlyView.
We introduce a novel method combining microfluidics, optogenetics, and human induced pluripotent stem cell (iPSC) technology to encapsulate single iPSC‐derived cardiomyocytes (iPSC‐CMs) in an optimal environment for functional characterization. This method enables direct genotype‐phenotype correlation for genetic studies and high‐throughput screening ...
Xiao‐Ting Wang, Rachel P. White, Yashasvi Tharani, Michael A. Finocchiaro, Leona M. Ripple, Maksymilian Prondzynski, Tania Konry, Vassilios J. Bezzerides   +7 more
wiley   +1 more source

mGluR7 inhibits glutamate release through a PKC-independent decrease in the activity of P/Q-type Ca2+ channels and by diminishing cAMP in hippocampal nerve terminals

, 2007
The modulation of calcium channels by metabotropic glutamate receptors (mGluRs) is a key event in the fine-tuning of neurotransmitter release. Here we report that, in hippocampal nerve terminals from adult rats, the inhibition of glutamate release by the
Martín Herranz, Ricardo, Sánchez-Prieto Borja, José, Torres Molina, Magdalena Isabel   +2 more
core   +1 more source

Recent Advances in Transparent Microelectrode Device Architecture and Fabrication Strategies for Biomedical Applications

Advanced Materials Technologies, EarlyView.
Transparent microelectrode arrays enable simultaneous optical and electrical electrophysiology with high spatiotemporal resolution, allowing multimodal observations of dynamic biological systems. Advances in materials and device architectures improve device performance by addressing key trade‐offs between optical transparency, impedance, and ...
Michael Abraham Listyawan, Tran Bach Dang, Chi Cong Nguyen, Yee Lap Pong, Tianruo Guo, Thanh Nho Do, Hoang‐Phuong Phan   +6 more
wiley   +1 more source