Results 251 to 260 of about 300,385 (307)
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L-type Ca2+ channels in Ca2+ channelopathies
Biochemical and Biophysical Research Communications, 2004Voltage-gated L-type Ca2+ channels (LTCCs) mediate depolarization-induced Ca2+ entry in electrically excitable cells, including muscle cells, neurons, and endocrine and sensory cells. In this review we summarize the role of LTCCs for human diseases caused by genetic Ca2+ channel defects (channelopathies).
Jörg, Striessnig +9 more
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European Journal of Pharmacology, 2002
The epilepsies encompass diverse seizure disorders afflicting as many as 50 million people worldwide. Many forms of epilepsy are intractable to current therapies and there is a pressing need to develop agents and strategies to not only suppress seizures, but also cure epilepsy.
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The epilepsies encompass diverse seizure disorders afflicting as many as 50 million people worldwide. Many forms of epilepsy are intractable to current therapies and there is a pressing need to develop agents and strategies to not only suppress seizures, but also cure epilepsy.
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Orexin receptors couple to Ca2+ channels different from store-operated Ca2+ channels
Neuroreport, 2001We have investigated Ca2+ release and receptor- and store-operated Ca2+ influxes in Chinese hamster ovary-K1 cells expressing human OX1 orexin receptor. Receptor-operated Ca2+ influx-response to 3 nM orexin-A was not affected by Gd3+ or 2-APB (2-aminoethoxydiphenyl borate), but was inhibited by Ni2+. Store-operated Ca2+ influx was blocked by Ni2+, Gd3+
J P, Kukkonen, K E, Akerman
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Inositol trisphosphate receptors: Ca2+-modulated intracellular Ca2+ channels
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1998The three subtypes of inositol trisphosphate (InsP3) receptor expressed in mammalian cells are each capable of forming intracellular Ca2+ channels that are regulated by both InsP3 and cytosolic Ca2+. The InsP3 receptors of many, though perhaps not all, tissues are biphasically regulated by cytosolic Ca2+: a rapid stimulation of the receptors by modest ...
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[Pharmacological basis of Ca2+ channels and Ca2+ channel antagonists].
Clinical calcium, 2005Ca2+ plays multiple roles in muscle E-C coupling, secretion, and neural transmission, in addition to survival, proliferation, and death of cells. The voltage-dependent L-type Ca2+ channel is a transmembrane protein that selectively permeates Ca2+ on activation by membrane depolarization.
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Biochemistry and Molecular Pharmacology of Ca2+ Channels and Ca2+-Channel Blockers
1988Most of what we now know of the structure of the Ca2+ channel comes from work that has been carried out with skeletal muscle membranes. This is because it was shown a number of years ago that the richest source of receptors for Ca2+ -channel blockers and particularly for l,4-dihydropyridines (DHP) ist the skeletal muscle T-tubule membrane system ...
J. Barhanin +9 more
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Artificial channels for confined mass transport at the sub-nanometre scale
Nature Reviews Materials, 2021Jie Shen, Gong-Ping Liu, Yu Han
exaly