Results 181 to 190 of about 56,978 (263)

Metabolomics of Eryngium heterophyllum by UHPLC‐QToF‐MS and In Silico Insights Into Potential Metabolic Syndrome Targets

Chemistry &Biodiversity, Volume 23, Issue 8, August 2026.
Eryngium heterophyllum has 85 metabolites according to nontargeted UHPLC‐QTOF‐MS profiling, with flavonoids and phenylpropionic acids emerging as significantly related bioactive families. In silico compound–disease–target networks connect 31 metabolites to inflammation, diabetes, obesity, and cardiovascular disease associated with metabolic syndrome ...
Citlaly Gutiérrez‐Rodelo, Laura Elisa Moreno Galván, Eric Estrada‐Lugo, Bharathi Avula, Ikhlas A. Khan, Andrés Navarrete   +5 more
wiley   +1 more source

Bioavailability of Sodium Iron Ethylenediaminetetraacetate, Ferrous Fumarate, and Ferrous Sulfate in Corn Flour Using Different INFOGEST Digestion and Caco-2 Cell Model Methods. [PDF]

Curr Dev Nutr
Zhang J, Lindshield BL.
europepmc   +1 more source

Synthesis of 4‐Hydroxyacetophenone‐Derived Bis‐Schiff Bases as Potent Cholinesterase Inhibitors: In Vitro Evaluation, Molecular Docking, DFT, and ADMET Analysis

Chemistry &Biodiversity, Volume 23, Issue 8, August 2026.
A series of 4‐hydroxyacetophenone‐based bis‐Schiff bases were synthesized as dual cholinesterase inhibitors. Compound 2i showed the highest AChE and BuChE inhibition, supported by molecular docking, DFT, QTAIM, and ADMET studies. SAR analysis revealed the role of methoxy substitution in enhancing activity, highlighting 2i as a promising lead candidate ...
Muhammad Daud, Zainab Zainab, Aftab Alam, Imtiaz Ahmad, Ahmed A. Elhenawy, Abdul Latif, Mumtaz Ali, Syed Adnan Ali Shah, Syahrul Imran, Ashwag S. Alanazi, Mohammed M. Alanazi, Manzoor Ahmad   +11 more
wiley   +1 more source

Transcriptomic comparison of human intestinal organoids and Caco-2 cells in modeling nutrient absorption: insights from infant formula and breast milk. [PDF]

NPJ Sci Food
Wang X, Zhang W, Yang S, Zheng C, Wang Z, Yang G, Huang C, Yao H, Huang K, Yan Y, Jiang S, Sun J, Xie Q, Zhang Y, Li X, Wang H.   +15 more
europepmc   +1 more source

Berberine Inhibited Tumor Growth Through Suppressing the WDR54/β‐catenin Signal Pathway in Colorectal Cancer

Cell Biology International, Volume 50, Issue 8, August 2026.
ABSTRACT Berberine (BBR), a natural alkaloid, exhibits potent anti‐tumor activity in colorectal cancer (CRC), but its mechanisms are not fully elucidated. Analysis of GEO datasets (GSE216908 and GSE184414) identified WDR54 as a key target of BBR treatment. In vitro, BBR treatment of CRC cell lines (HT‐29 and SW480) markedly inhibited cell proliferation,
Qin Chen, Qi Chen, Fenqiong Tang
wiley   +1 more source

Phenolic Compounds of Grape Pomace Skin Released During SHIME Colonic Fermentation Shape the Transcriptomic Profile of Tight Junctions, Improving the Barrier Properties in Caco-2 Cells. [PDF]

Int J Mol Sci
Hidalgo M, Vera F, Concepción-Alvarez A, Rubio V, Railef B, Meneses-Pacheco J, Moreno M, Oyarzún M, Camargo AC, Bridi R, Fuenzalida K, Gonzales E, Pacheco I, Añazco C, Pulgar R, Porras O.   +15 more
europepmc   +1 more source

Development of plant‐derived biomimetic nanoparticles as a novel targeted drug delivery platform

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
Plant‐derived biomimetic nanoparticles (PD‐BNPs) represent a sustainable and biocompatible nanoplatform for targeted drug delivery. This review highlights their therapeutic potential, engineering strategies, and translational challenges toward precision nanomedicine applications. Abstract Plant‐derived biomimetic nanoparticles (PD‐BNPs) have emerged as
Jihad Hasan, Asnaf Nihan Shuvo, Md. Rezaul Karim Sheikh, A. Nayeem Faruqui   +3 more
wiley   +1 more source

Valorization of Carménère Grape Pomace: Extraction, Microencapsulation, and Evaluation of the Bioactivity of Polyphenols in Caco-2 Cells. [PDF]

Int J Mol Sci
Valenzuela-Bustamante P, Cornejo P, Nolan N, Concepción-Alvarez A, Bridi R, Rincón-Cervera MÁ, Porras O, de Camargo AC, Arias-Santé MF.   +8 more
europepmc   +1 more source

Effects of Lactobacillus‐Mediated Functionalization of Dendrobium officinale Polysaccharides: A Study From Physicochemical Properties and Structural Changes to Anti‐Inflammatory Activity

eFood, Volume 7, Issue 4, August 2026.
Lactic acid bacteria (LAB) fermentation cleaves specific glycosidic bonds in Dendrobium officinale polysaccharides (DOPs), reducing molecular weight and enhancing anti‐inflammatory activity through regulation of inflammatory cytokines, oxidative stress, and intestinal barrier function.
Dingding Hong, Hui Ye, Xiaojun Huang
wiley   +1 more source

A Comparison of Marine and Non-Marine Magnesium Sources for Bioavailability and Modulation of TRPM6/TRPM7 Gene Expression in a Caco-2 Epithelial Cell Model. [PDF]

Nutrients
Demehin OA, Ryan M, Higgins T, Moura Motta B, Jähnichen T, O'Connell S.   +5 more
europepmc   +1 more source