Results 181 to 190 of about 97,542,255 (296)

Astragaloside IV and Ferroptosis Modulation in Pathological Cardiac Hypertrophy: Current Evidence, an Integrative Hypothesis, and Future Directions

Pharmacology Research &Perspectives, Volume 14, Issue 6, December 2026.
ABSTRACT Pathological cardiac hypertrophy is initially an adaptive response to sustained mechanical, neurohormonal, or metabolic stress; however, it can progress to fibrosis, contractile dysfunction, arrhythmia, and heart failure. Ferroptosis is a type of regulated cell death caused by iron‐dependent phospholipid peroxidation.
Pengbo Liu, Yongzhi Deng
wiley   +1 more source

Mechanisms of Cell Uptake and Transport of Xanthophylls in the Caco-2 Cell Model. [PDF]

Nutrients
Wu F, Chen N, Peng Y, Li M, Ni Y, Li T, Liu R, Wen X.   +7 more
europepmc   +1 more source

Sedative Potential of L (+)‐Tartaric Acid: Behavioral Evidence With In Silico Insights Into Possible GABAergic Interaction

Brain and Behavior, Volume 16, Issue 11, November 2026.
ABSTRACT Purpose Insomnia is a prevalent neurological disorder often caused by stress, anxiety, and imbalances in the GABAergic system. Although benzodiazepines like diazepam (DZP) are commonly prescribed, their long‐term use is associated with adverse effects, including dependence and impaired coordination.
Sumaya Akter Bithi, Anike Chakrabarty, Khadija Akter, Chinmoy Kumar Saha, Mohammad Y. Alshahrani, Md. Arif Hossain, Emon Mia, Noshin Tasnim Yana, Afiya Ajmee, Proma Mandal, Md. Sakib Al Hasan, Muhammad Torequl Islam   +11 more
wiley   +1 more source

AdipoRon, an Adiponectin Receptor Agonist, Promotes Intestinal Epithelial Differentiation in Caco-2 Colorectal Adenocarcinoma Cells. [PDF]

Biomedicines
Mallardo M, Memon F, D'Auria L, Pagliaro R, Daniele A, Nigro E.   +5 more
europepmc   +1 more source

Divergent Roles of PIK3C3 in KRAS‐Wild‐Type and KRAS‐Mutant Advanced Colorectal Cancer: Implications for 5‐Fluorouracil Sensitivity and Prognosis

Cancer Medicine, Volume 15, Issue 11, November 2026.
PIK3C3 plays divergent roles in KRAS‐WT and KRAS‐mutant CRCs, viz. targeting PIK3C3 suppresses KRAS/ERK pathway in KRAS‐WT CRC, while enhancing 5‐FU sensitivity in KRAS‐mutant CRC. ABSTRACT Introduction Phosphatidylinositol 3‐kinase catalytic subunit type 3 (PIK3C3) is central to autophagy, which supports cancer adaptation to environmental stresses and
Chien‐An Chu, Nan‐Haw Chow, Jiu‐Yao Wang, Chen Chang, Peng‐Chan Lin, Yu‐Min Yeh, Bo‐Wen Lin, Yi‐Wen Wang, Yun‐Hao Dai, Yi‐Lin Chen, Po‐Chuan Chen, Shang‐Hung Chen, Ren‐Hao Chan, Chung‐Liang Ho, Che‐Wei Hsu, Chung‐Ta Lee   +15 more
wiley   +1 more source

Therapeutic Potential of Propolis in Ulcerative Colitis: A Review of Preclinical Evidence

Chemistry &Biodiversity, Volume 23, Issue 11, November 2026.
This review compiles preclinical evidence from studies that investigate the therapeutic potential of propolis extracts derived from different botanical origins, as well as their main bioactive constituents, in the context of ulcerative colitis. The observed beneficial effects are primarily attributed to their antioxidant, immunomodulatory, and anti ...
Thayná Fernandes Barros, Gabriel Gomes Vila Nova, Rosane Nassar Meireles Guerra, Flavia Raquel Fernandes do Nascimento, Afonso Gomes Abreu   +4 more
wiley   +1 more source

Comparative transcriptomic points of departure analysis of pesticides in human Caco-2 and Hep G2 cells. [PDF]

NAM J
Xu K, Mittal K, Basu N.
europepmc   +1 more source

Physiologically Based Pharmacokinetic Modeling to Assess Transporter‐Mediated Drug–Drug Interactions in Support of Labeling Recommendations for Zavegepant Nasal Spray

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1402-1413, November 2026.
Zavegepant nasal spray, a calcitonin gene‐related peptide receptor antagonist indicated for acute treatment of migraine with or without aura in adults, is a substrate for organic anion transporting polypeptide 1B3 (OATP1B3), Na+/taurocholate cotransporting polypeptide (NTCP), P‐glycoprotein (P‐gp), and cytochrome P450 3A4 (CYP3A4).
Alice Ke, Ernesto Callegari, Manthena V.S. Varma, Mayur K Ladumor, Chieko Muto, Richard J. Bertz, Hannah M. Jones, Vaishali Sahasrabudhe, Jing Liu   +8 more
wiley   +1 more source

Phytochemical Characterization and Mechanistic Insights into the Cytotoxic Effects of Bougainvillea glabra Bract Extract in Caco-2 Colorectal Adenocarcinoma Cells. [PDF]

Plant Foods Hum Nutr
Leal-Alcazar MC, Bautista-Palestina F, Rocha-Pizaña M, Monribot-Villanueva JL, Guerrero-Analco JA, Mojica L, Contreras J, Luna-Vital DA.   +7 more
europepmc   +1 more source

Advances in New Approach Methodologies at FDA's Division of Applied Regulatory Science

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1250-1254, November 2026.
New Approach Methodologies (NAMs) represent a paradigm shift in drug development and regulatory science, offering human‐relevant alternatives to traditional preclinical models. This mini‐review highlights recent advances in NAM development, validation, and regulatory application from FDA's Division of Applied Regulatory Science (DARS).
Ksenia Blinova, Kimberly Chiu, Anik Chaturbedi, Jahan Cooper, Tromondae K. Feaster, Paula L. Hyland, Lidiya Stavitskaya, Wendy W. Wu, Jeffry Florian, Rodney Rouse   +9 more
wiley   +1 more source