Results 191 to 200 of about 97,542,255 (296)

Biological Activity of Plant-Derived Peptides, Hydrolysates and Digests in the Caco-2 Intestinal Epithelial Model: A Systematic Critical Review. [PDF]

Int J Mol Sci
Perna S, Di Nunzio M.
europepmc   +1 more source

From Prediction to Decision Making: PBPK and QSP as Regulatory‐Grade NAMs

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1195-1207, November 2026.
New approach methodologies (NAMs) encompass a diverse and rapidly evolving set of experimental and computational tools designed to generate human‐relevant mechanistic data for use in drug development and regulatory decision making. Experimental NAMs provide insights into drug disposition, pharmacological activity, and disease biology that are difficult
Karen Rowland Yeo, Piet H. van der Graaf
wiley   +1 more source

Probe Cytotoxic and Oxidative Stress Effects of Nanoplastics on Caco-2 Cells: Insights from Raman Spectroscopy and Machine Learning. [PDF]

Sensors (Basel)
Gustafson B, Kosari N, Brothersen E, Mosher M, Zhou A.   +4 more
europepmc   +1 more source

Epigenetic silencing of PDLIM4 promotes colorectal cancer by impairing BTF3 autophagic degradation and activating PI3K/Akt signalling

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
• DNMT3A‐mediated PDLIM4 promoter hypermethylation is an early event in colorectal tumorigenesis. • Restoring PDLIM4 suppresses CRC proliferation and stemness while promoting apoptosis in vitro and in vivo. • PDLIM4 promotes the autophagic‐lysosomal degradation of BTF3 and restrains PI3K/Akt signalling.
Jiaxing Wang, Chuan‐Guo Guo, Lingyu Qi, Songyuan Hou, Boshen Lin, Tong Ye, Ye Zong, Shutian Zhang, Nan Zhang, Peng Li, Si Liu   +10 more
wiley   +1 more source

Biopharmaceutical Characterization of Grapiprant Within the BCS Framework Under Canine-Relevant Conditions: Solubility and Caco-2 Permeability Assessment. [PDF]

Pharmaceutics
Wen Z, Sun X, Chen S, Meng J, Yu R, Guo S, Cao X.   +6 more
europepmc   +1 more source

Comprehensive Evaluation of Gastrointestinal Factors Influencing the Stability and Function of mRNA‐Encapsulated Lipid Nanoparticles

Drug Development Research, Volume 87, Issue 7, November 2026.
ABSTRACT Owing to the intrinsic instability of mRNA, its routes of administration are limited, and to date, only injectable delivery has been clinically applied. In contrast, oral administration exposes mRNA to a variety of substances in the gastrointestinal (GI) tract.
Toma Shinkai, Koki Ogawa, Mohamed S. Mohamed, Tetsuya Ozeki   +3 more
wiley   +1 more source

<i>Citrus</i> Pomace-Derived Plant Complexes Enhance Caco-2 Wound Closure In Vitro and Modulate Selected Probiotic Strains. [PDF]

Antioxidants (Basel)
Ingegneri M, Imbesi M, Belaid S, Mangano M, Ombra MN, Nazzaro F, Smeriglio A, Trombetta D.   +7 more
europepmc   +1 more source

Salicylic Acid as a Food‐Derived Bioactive Constituent of Tiaoqi Daozhi Decoction: A Potential Functional Food Ingredient to Restoring Gut Barrier Function in Constipation‐Predominant IBS

Food Science &Nutrition, Volume 14, Issue 11, November 2026.
Tiaoqi Daozhi Decoction (TQDZD) is a classic formulation composed of eight medicine‐food homologous botanicals. UPLC‐MS/MS profiling identified 1962 non‐redundant compounds in its aqueous extract, predominantly phenolic acids and flavonoids, of which 107 metabolites were systemically bioavailable.
Min Duan, Lixia Huang, Yingyue Xu, Ya Huang, Xiaojun Yang   +4 more
wiley   +1 more source

The effects of β-caryophyllene on butyrate utilization and metabolism in Caco-2 cells. [PDF]

Sci Rep
Scroggins H, Kent-Dennis C, May J, Harmon DL, Klotz JL.   +4 more
europepmc   +1 more source

Colonic Barrier Dysfunction and Inflammation Induced by Nano‐/Micro‐Plastics Fibers in Mice via the FAK/NF‐κB/iNOS and TLR4/NF‐κB/iNOS Pathways

Journal of Applied Toxicology, Volume 46, Issue 11, Page 4144-4159, November 2026.
ABSTRACT As emerging environmental contaminants, nano‐ and micro‐plastics (NMPs) have drawn increasing research attention due to potential hazards to organisms. Particle shape is a key factor influencing the toxic effects of NMPs, and NMPs of different shapes cause varying degrees of tissue damage. We investigated the specific mechanisms of polystyrene
Yuting Li, Shibo Bao, Puyang Huang, Jiahui Wang, Hongfeng Li, Yahong Liu, Kai Wang, Jianjun Du, Lingjun Yan, Guowei Pan, Wei Sun   +10 more
wiley   +1 more source